High-charge capacity electrodes to deliver direct current nerve conduction block
The present disclose generally relates to high-charge capacity electrodes that include a substrate and a coating covering at least a portion of the substrate that includes active particles held together by a biocompatible binding material. One aspect of the present disclosure relates a system that can block conduction in a nerve. The system can include a current generator that generates a direct current (DC). The system can also include a high-charge capacity electrode that can be coupled to the current generator to deliver the DC to block conduction in a nerve.
1. A method, comprising:
placing a high-charge capacity electrode, coupled to a current generator, in proximity to a nerve;
wherein the high-charge capacity electrode comprises:
an electrically conductive substrate; and
a coating covering at least a portion of the substrate and adhering to the at least the portion of the substrate, wherein the coating is configured to be in contact with or exposed to the nerve;
wherein the coating consists of active nano-particles held together by a biocompatible binder material that adheres to at least the portion of the substrate, and
wherein the coating provides an electronic double layer capacitor (EDLC) configured to charge and discharge;
applying a direct current (DC), generated by the current generator, to the nerve without generating damaging reaction products, wherein the DC has an amplitude sufficient to alter transmission of action potentials in the nerve and the DC is applied by discharging the EDLC without generating irreversible reaction products; and
altering the transmission of the action potentials in the nerve based on the applied DC without causing damage to the nerve and/or the high-charge capacity electrode.
2. The method of claim 1 , wherein the altering of the transmission of action potentials in the nerve comprises blocking the transmission of the action potentials in the nerve or attenuating the transmission of the action potentials in the nerve.
3. The method of claim 1 , wherein the DC comprises a bi-phasic waveform.
4. The method of claim 3 , wherein the bi-phasic waveform comprises a first phase that produces electrochemical reaction products and a second phase that reverses the electrochemical reaction products.
5. The method of claim 1 , wherein the high-charge capacity electrode is placed alongside the nerve.
6. The method of claim 1 , wherein the high-charge capacity electrode is placed perpendicular to a long axis of the nerve.