Compounds and methods for promoting stress resistance

1. A method of treating lung cancer in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of Formula (Ia) or a pharmaceutically acceptable salt thereof:

wherein:

R 4 is R 29 -substituted or unsubstituted phenyl or R 29 -substituted or unsubstituted 5 or 6 membered heteroaryl;

R 29 is halogen, —CF 3 , —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC═(O)NHNH 2 , —NHC═(O)NH 2 , —NHSO 2 H, —NHC═(O)H, —NHC(O)—OH, —NHOH, —OCF 3 , —OCHF 2 , phenoxy, R 30 -substituted or unsubstituted C 1 -C 6 alkyl, R 30 -substituted or unsubstituted 2 to 6 membered heteroalkyl, R 30 -substituted or unsubstituted C 3 -C 6 cycloalkyl, R 30 -substituted or unsubstituted 3 to 6 membered heterocycloalkyl, R 30 -substituted or unsubstituted phenyl, or R 30 -substituted or unsubstituted 5 to 6 membered heteroaryl;

R 30 is halogen, —CF 3 , —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC═(O)NHNH 2 , —NHC═(O)NH 2 , —NHSO 2 H, —NHC═(O)H, —NHC(O)—OH, —NHOH, —OCF 3 , —OCHF 2 , R 31 -substituted or unsubstituted C 1 -C 6 alkyl, R 31 -substituted or unsubstituted 2 to 6 membered heteroalkyl, R 31 -substituted or unsubstituted C 3 -C 6 cycloalkyl, R 31 -substituted or unsubstituted 3 to 6 membered heterocycloalkyl, R 31 -substituted or unsubstituted phenyl, or R 31 -substituted or unsubstituted 5 to 6 membered heteroaryl;

R 31 is halogen, oxo, —CF 3 , —CCl 3 , —CN, —S(O)CH 3 , —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —C(O)CH 3 , —CH 2 CH 2 OH, —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC═(O)NHNH 2 , —NHC═(O)NH 2 , —NHSO 2 H, —NHC═(O)H, —NHC(O)OH, —NHOH, —OCH 3 , —OCF 3 , —OCHF 2 unsubstituted C 1 -C 6 alkyl, unsubstituted 2 to 6 membered heteroalkyl, unsubstituted C 3 -C 6 cycloalkyl, unsubstituted 3 to 6 membered heterocycloalkyl, unsubstituted phenyl, or unsubstituted 5 to 6 membered heteroaryl.

2. The method of claim 1 , wherein the compound of Formula (Ia) is:

3. The method of claim 1 , wherein the lung cancer is non-small cell lung cancer.

4. A method of inhibiting proliferation of lung cancer cells or inhibiting survival of lung cancer cells, the method comprising contacting the lung cancer cells with a compound of formula (Ia) or a pharmaceutically acceptable salt thereof;

wherein:

R 4 is R 29 -substituted or unsubstituted phenyl or R 29 -substituted or unsubstituted 5 or 6 membered heteroaryl;

R 29 is halogen, —CF 3 , —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC═(O)NHNH 2 , —NHC═(O)NH 2 , —NHSO 2 H, —NHC═(O)H, —NHC(O)—OH, —NHOH, —OCF 3 , —OCHF 2 , phenoxy, R 30 -substituted or unsubstituted C 1 -C 6 alkyl, R 30 -substituted or unsubstituted 2 to 6 membered heteroalkyl, R 30 -substituted or unsubstituted C 3 -C 6 cycloalkyl, R 30 -substituted or unsubstituted 3 to 6 membered heterocycloalkyl, R 30 -substituted or unsubstituted phenyl, or R 30 -substituted or unsubstituted 5 to 6 membered heteroaryl;

R 30 is halogen, —CF 3 , —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC═(O)NHNH 2 , —NHC═(O)NH 2 , —NHSO 2 H, —NHC═(O)H, —NHC(O)—OH, —NHOH, —OCF 3 , —OCHF 2 , R 31 -substituted or unsubstituted C 1 -C 6 alkyl, R 31 -substituted or unsubstituted 2 to 6 membered heteroalkyl, R 31 -substituted or unsubstituted C 3 -C 6 cycloalkyl, R 31 -substituted or unsubstituted 3 to 6 membered heterocycloalkyl, R 31 -substituted or unsubstituted phenyl, or R 31 -substituted or unsubstituted 5 to 6 membered heteroaryl;

R 31 is halogen, oxo, —CF, —CCl 3 , —CN, —S(O)CH 3 , —OH, —NH, —COOH, —CONH 2 , —NO 2 , —C(O)CH 3 , —CH 2 CH 2 OH, —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC═(O)NHNH 2 , —NHC═(O)NH 2 , —NHSO 2 H, —NHC═(O)H, —NHC(O)OH, —NHOH, —OCH, —OCF 3 , —OCHF 2 , unsubstituted C 1 -C 6 alkyl, unsubstituted 2 to 6 membered heteroalkyl, unsubstituted C 3 -C 6 cycloalkyl, unsubstituted 3 to 6 membered heterocycloalkyl, unsubstituted phenyl, or unsubstituted 5 to 6 membered heteroaryl.

5. The method of claim 4 , wherein the compound of Formula (Ia) is:

6. The method of claim 4 , wherein the lung cancer cells are non-small cell lung cancer cells.

7. The method of claim 2 , wherein the compound of Formula (Ia) is:

8. The method of claim 2 , wherein the compound of Formula (Ia) is:

9. The method of claim 2 , wherein the compound of Formula (Ia) is: