Capsule with internal diaphragm and solid ingredients
A two-compartment capsule includes a body, a diaphragm between, which seals off the body and provides a first compartment to hold a first dry ingredient, and a cap applied to the body whereby a space between the inner portion of the cap and the diaphragm defines a second compartment for holding a second dry ingredient. This disclosure also provides particular formulations for use in such a capsule. Examples include a probiotic, a digestive enzyme, an expectorant, a bronchodilator, a stool softener, a platelet aggregation inhibitor, a form or derivative of vitamin E, a statin, and aspirin.
1. A multi-compartment capsule comprising:
a body;
a diaphragm having a bottom and two sidewalls extending from the bottom and defining a top edge, the diaphragm extending into the body and forming a first compartment defined by a first surface of the diaphragm and the body; and
a cap mounted to the body and opposed to the diaphragm, the cap forming a second compartment defined by an opposing surface of the diaphragm and the cap;
wherein the two sidewalls of the diaphragm extend along and contact the inner surface of the body and the top edge is flush with an open end of the body, forming a seal between the diaphragm and the body;
wherein the first compartment and the second compartment each contain one or more powders; and
wherein the multi-compartment capsule is a size 00 capsule.
2. The capsule of claim 1 , wherein the first compartment is hermetically sealed.
3. The capsule of claim 1 , wherein the one or more powders comprises an aspirin, a statin, a menstrual pain reliever, an agent for increasing bone density, an agent for relieving hot flashes, coenzyme Q10 (CoQ10), a cholesterol reducer, a thyroid hormone, a bronchodilator, an expectorant, a decongestant, an anti-inflammatory agent, a prebiotic, a probiotic, a digestive enzyme, a stool softener, anti-platelet aggregation agent, a platelet aggregation inhibitor, a vitamin, vitamin E, vitamin D3, a pain reliever, an isoflavone derivative, medicinal herbs, a corticosteroid, a proton pump inhibitor, a pharmaceutical agent, a nonsteroidal anti-inflammatory drug, or a combination thereof.
4. The capsule of claim 3 , wherein the digestive enzyme is selected from the group consisting of amylase, alpha-amylase, protease, alpha-galactosidase, beta-gulcanase, galactomannase, lactase, lipase, cellulase, hemicellulase, phytase, sucrase, invertase, pectinase, maltase, malt diastase, glucoamylase, xylanase, pullulanase, peptidase and dipeptidyl peptidas IV, serratia peptidase, lysozyme, bromelian, papain, and combinations thereof.
5. The capsule of claim 3 , wherein the pharmaceutical agent is selected from selected from the group consisting of aspirin, a statin, ipriflavone, cohosh, castus, coenzyme Q10 (CoQ10), gauifenesin, althea root, antimony pentasulfide, creosote, guaiacolsulfonate, ipecacuanha (syrup of ipecac), levoverbenone, potassium iodide, senega, tyloxapol, ammonium chloride, salbutamol, albuterol, levosalbutamol, levalbuterol, pirbuterol, epinephrine, ephedrine, terbutaline, salmeterol, clenbuterol, formoterol, bambuerol, indacaterol, ephrinesulfate, ticlopidine, clopidogrel, prasugrel, ticagrelor, cilostazol, vorapaxar, trifusal, dipyridamole, a tocotrienol, and combinations thereof.
6. The capsule of claim 3 , wherein the statin is selected from the group consisting of atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin, and combinations thereof.
7. The capsule of claim 3 , wherein the probiotic is selected from the group consisting of selected from the group consisting of Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus gasseri, Lactobacillus helveticus, Lactobacillus bulgaricus, Lactobacillus delbrueckii, Lactobacillus plantarum, Lactobacillus paracasei, Lactobacillus salivarius Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus brevis, Lactobacillus breve, Streptococcus thermophilus, Bifidobacterium infantis, Bifidobacterium lactis, Bifidobacterium longum, Bifidobacterium bifidum, Bifidobacterium coagulans, Bifidobacterium breve, Bifidobacterium animalis, Bifidobacterium subtilis, Saccharomyces boulardi , and combinations thereof.
8. The capsule of claim 1 , wherein the one or more powders comprises from about 1 million colony forming units to about 100 billion colony forming units of a probiotic.
9. The capsule of claim 1 , wherein the one or more powders comprises from about 10 mg to about 1000 mg of a digestive enzyme.
10. The capsule of claim 1 , wherein the first compartment comprises from about 1 million colony forming units to about 100 billion colony forming units of a probiotic, and the second compartment comprises from about 10 mg to about 1000 mg of a digestive enzyme.
11. The capsule of claim 1 , wherein the first compartment comprises from about 10 mg to about 1000 mg of a digestive enzyme, and the second compartment comprises from about 1 million colony forming units to about 100 billion colony forming units of a probiotic.
12. The capsule of claim 1 , wherein the one or more powders comprises from about 10 mg to about 500 mg of aspirin.
13. The capsule of claim 1 , wherein the one or more powders comprises from about 1 mg to about 100 mg of a statin.
14. The capsule of claim 1 , wherein the one or more powders contained in the first compartment are not crushed to accommodate the diaphragm.
15. A multi-compartment capsule comprising:
a body;
a diaphragm having a bottom and two sidewalls, the two sidewalls extending along and contacting an inner surface of the body to form a seal therebetween, wherein a first compartment is defined by the body and a first surface of the diaphragm; and
a cap mounted to the body and opposed to the diaphragm, wherein a second compartment is defined by the cap and a second surface of the diaphragm,
wherein the first compartment and the second compartment each contain one or more solid ingredients.