Coating agent for flow passage
The invention provides a coating agent for a flow passage which comprises a copolymer containing a recurring unit which contains an organic group of the formula (a) wherein U a1 and U a2 are defined herein, and a recurring unit which contains an organic group of the formula (b) wherein U b1 , U b2 , U b3 , and An − are defined herein. The invention also provides a flow passage device having the coating agent for a flow passage on at least part of an inner surface of a flow passage, a platelet-producing flow passage device and a method for manufacturing the same.
1. A coating agent for a flow passage which comprises a (meth)acrylic copolymer comprising a recurring unit which contains an organic group of formula (a1) and a recurring unit which contains an organic group of formula (b1):
wherein
T a and T b each independently represent a hydrogen atom or a methyl group;
Q a and Q b each independently represent an ester bond;
R a and R b each independently represent a linear or branched alkylene group having 1 to 10 carbon atoms which may be substituted by a halogen atom;
U a1 , U a2 , U b1 , U b2 and U b3 each independently represent a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms;
An − represents an anion selected from the group consisting of a halide ion, an inorganic acid ion, a hydroxide ion and an isothiocyanate ion; and
m represents an integer of 0 to 6; and
wherein the (meth)acrylic copolymer contains the recurring unit which contains the organic group of the formula (a) in an amount from 3 mol % to 80 mol %.
2. The coating agent for a flow passage according to claim 1 , wherein the (meth)acrylic copolymer further comprises a recurring unit which contains an organic group of formula (c):
—R c (C)
wherein R c represents a linear or branched alkyl group having 1 to 18 carbon atoms, a cyclic hydrocarbyl group having 3 to 10 carbon atoms, an aryl group having 6 to 10 carbon atoms, an aralkyl group having 7 to 15 carbon atoms or an aryloxyalkyl group having 7 to 15 carbon atoms, where the above-mentioned aryl portion may be substituted by a linear or branched alkyl group having 1 to 5 carbon atoms which may be substituted by a halogen atom.
3. The coating agent for a flow passage according to claim 2 , wherein the (meth)acrylic copolymer further comprises a recurring unit of formula (c1):
wherein
T c represents a hydrogen atom or a methyl group;
Q c represents a single bond, an ether bond or an ester bond; and
R c represents a linear or branched alkyl group having 1 to 18 carbon atoms, a cyclic hydrocarbyl group having 3 to 10 carbon atoms, an aryl group having 6 to 10 carbon atoms, an aralkyl group having 7 to 15 carbon atoms or an aryloxyalkyl group having 7 to 15 carbon atoms, where the above-mentioned aryl portion may be substituted by a linear or branched alkyl group having 1 to 5 carbon atoms which may be substituted by a halogen atom.
4. A flow passage device having the coating agent for a flow passage according to claim 1 on at least part of an inner surface of a flow passage.
5. A platelet-producing flow passage device having the coating agent for a flow passage according to claim 1 on at least part of an inner surface of a flow passage.
6. A method for manufacturing a flow passage device having a coating agent for a flow passage on at least part of an inner surface of a flow passage, which comprises a process of contacting the coating agent for a flow passage according to claim 1 with at least part of an inner surface of the flow passage.
7. A method for manufacturing a platelet-producing flow passage device having a coating agent for a flow passage on at least part of an inner surface of a flow passage, which comprises a process of contacting the coating agent for a flow passage according to claim 1 with at least part of an inner surface of the flow passage.
8. The method for manufacturing a flow passage device of claim 6 , wherein the coating agent has an ability to inhibit adhesion of a biological substance with at least part of an inner surface of the flow passage after forming the flow passage.
9. The method for manufacturing a platelet-producing flow passage device of claim 7 , wherein the coating agent has an ability to inhibit adhesion of a biological substance with at least part of an inner surface of the flow passage after forming the flow passage.
10. A flow passage device having a coating agent for a flow passage on at least part of an inner surface of a flow passage, obtained by a process of feeding the coating agent for a flow passage to the flow passage,
wherein the coating agent for a flow passage comprises a (meth)acrylic copolymer comprising a recurring unit which contains an organic group of formula (a1) and a recurring unit which contains an organic group of formula (b1):
wherein
T a and T b each independently represent a hydrogen atom or a methyl group;
Q a and Q b each independently represent an ester bond;
R a and R b each independently represent a linear or branched alkylene group having 1 to 10 carbon atoms which may be substituted by a halogen atom;
U a1 , U a2 , U b1 , U b2 and U b3 each independently represent a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms;
An − represents an anion selected from the group consisting of a halide ion, an inorganic acid ion, a hydroxide ion and an isothiocyanate ion; and
m represents an integer of 0 to 6; and
wherein the (meth)acrylic copolymer contains the recurring unit which contains the organic group of the formula (a) in an amount from 3 mol % to 80 mol %.
11. The flow passage device according to claim 10 , wherein the (meth)acrylic copolymer further comprises a recurring unit which contains an organic group of formula (c):
—R c (C)
wherein R c represents a linear or branched alkyl group having 1 to 18 carbon atoms, a cyclic hydrocarbyl group having 3 to 10 carbon atoms, an aryl group having 6 to 10 carbon atoms, an aralkyl group having 7 to 15 carbon atoms or an aryloxyalkyl group having 7 to 15 carbon atoms, where the above-mentioned aryl portion may be substituted by a linear or branched alkyl group having 1 to 5 carbon atoms which may be substituted by a halogen atom.
12. The flow passage device according to claim 10 , wherein the (meth)acrylic copolymer further comprises a recurring unit of formula (c1):
wherein
T c represents a hydrogen atom or a methyl group;
Q c represents a single bond, an ether bond or an ester bond; and
R c represents a linear or branched alkyl group having 1 to 18 carbon atoms, a cyclic hydrocarbyl group having 3 to 10 carbon atoms, an aryl group having 6 to 10 carbon atoms, an aralkyl group having 7 to 15 carbon atoms or an aryloxyalkyl group having 7 to 15 carbon atoms, where the above-mentioned aryl portion may be substituted by a linear or branched alkyl group having 1 to 5 carbon atoms which may be substituted by a halogen atom.
13. The flow passage device according to claim 10 , which is a platelet-producing flow passage device.
14. A method of forming a coating with a coating agent which comprises applying the coating agent to a flow passage, such that the coating agent fixes to at least part of an inner surface of the flow passage via ionic bonding, wherein the coating agent comprises a (meth)acrylic copolymer comprising a recurring unit which contains an organic group of formula (a) and a recurring unit which contains an organic group of formula (b):
wherein U a1 , U a2 , U b1 , U b2 and U b3 each independently represent a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms, and An − represents an anion selected from the group consisting of a halide ion, an inorganic acid ion, a hydroxide ion and an isothiocyanate ion, and
wherein the (meth)acrylic copolymer contains the recurring unit which contains the organic group of the formula (a) in an amount from 3 mol % to 80 mol %.
15. The method according to claim 14 , wherein the (meth)acrylic copolymer further comprises a recurring unit which contains an organic group of formula (c):
—R c (C)
wherein R c represents a linear or branched alkyl group having 1 to 18 carbon atoms, a cyclic hydrocarbyl group having 3 to 10 carbon atoms, an aryl group having 6 to 10 carbon atoms, an aralkyl group having 7 to 15 carbon atoms or an aryloxyalkyl group having 7 to 15 carbon atoms, where the above-mentioned aryl portion may be substituted by a linear or branched alkyl group having 1 to 5 carbon atoms which may be substituted by a halogen atom.
16. The method according to claim 14 , wherein the (meth)acrylic copolymer comprises recurring units of formulae (a1) and (b1):
wherein
T a and T b each independently represent a hydrogen atom or a methyl group;
Q a and Q b each independently represent an ester bond;
R a and R b each independently represent a linear or branched alkylene group having 1 to 10 carbon atoms which may be substituted by a halogen atom;
U a1 , U a2 , U b1 , U b2 and U b3 each independently represent a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms;
An − represents an anion selected from the group consisting of a halide ion, an inorganic acid ion, a hydroxide ion and an isothiocyanate ion; and
m represents an integer of 0 to 6.
17. The method according to claim 14 , wherein the (meth)acrylic copolymer further comprises a recurring unit of formula (c1):
wherein
T c represents a hydrogen atom or a methyl group;
Q c represents a single bond, an ether bond or an ester bond; and
R c represents a linear or branched alkyl group having 1 to 18 carbon atoms, a cyclic hydrocarbyl group having 3 to 10 carbon atoms, an aryl group having 6 to 10 carbon atoms, an aralkyl group having 7 to 15 carbon atoms or an aryloxyalkyl group having 7 to 15 carbon atoms, where the above-mentioned aryl portion may be substituted by a linear or branched alkyl group having 1 to 5 carbon atoms which may be substituted by a halogen atom.
18. The method according to claim 14 , wherein the flow passage is in a platelet-producing flow passage device.