CD200 inhibitors and methods of use thereof
The present invention provides in certain embodiments compositions comprising at least one CD200 inhibitor, and methods of reversing or modulating immune suppression in a patient having a disease or disorder arising from abnormal cell growth, function or behavior, which method comprises administering to a patient in need thereof a CD200 inhibitor composition.
1. A composition comprising a CD200 inhibitor, wherein the CD200 inhibitor is a mutant of naturally-occurring CD200 peptide, wherein the CD200 inhibitor is 13 to 20 amino acids in length, and wherein the peptide comprises the amino acid sequence VTWQKKAAVSPEN (SEQ ID NO: 21).
2. The composition of claim 1 , further comprising:
(i) a cancer vaccine;
(ii) a cancer vaccine that is a tumor lysate; or
(iii) a tumor lysate that is substantially devoid of CD200.
3. The composition of claim 1 , further comprising a pharmaceutically acceptable carrier and/or diluent and/or an adjuvant.
4. The composition of claim 1 , wherein the composition further comprises a cancer therapy.
5. A kit for treating cancer, comprising:
(a) a first pharmaceutical composition comprising a composition of claim 1 ; and
(b) instructions for use.
6. A nucleic acid molecule encoding a CD200 inhibitor, wherein the CD200 inhibitor is a mutant of naturally-occurring CD200 peptide, wherein the CD200 inhibitor is 13 to 20 amino acids in length, and wherein the peptide comprises the amino acid sequence VTWQKKAAVSPEN (SEQ ID NO:21).
7. An expression cassette comprising the molecule of claim 6 .
8. A viral vector comprising the expression cassette of claim 7 .