Aminonaphthoquinone compounds for treatment and/or prevention of fibrosis diseases
The invention relates to the use of a compound of Formula (I) as described herein and its effective dose in the prevention and/or treatment of fibrosis diseases. The compound can effectively prevent and/or treat a fibrosis disease without cytotoxicity or genotoxicity.
1. A method for treatment of or liver fibrosis in a subject, comprising administering an effective amount of a compound of 4-(((3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino)methyl)-N-(pyridin-4-yl)benzamide, having the following formula:
or a pharmaceutically acceptable salt, solvate or prodrug thereof as an active ingredient to the subject.
2. The method of claim 1 , wherein the effective amount of the active ingredient used in the method of the invention ranges from about 1.5 mg/kg/day to about 20 mg/kg/day, about 5.0 mg/kg/day to about 15 mg/kg/day, or about 1.5 mg/kg/day to about 8 mg/kg/day.
3. The method of claim 1 , wherein the active ingredient is further simultaneously, separately, or sequentially co-administered with a second anti-fibrosis agent.
4. The method of claim 3 , wherein the second anti-fibrosis agent is pirfenidone, nintedanib, LOXL2 antibody, simtuzumab, IL-13 antibody, lebrikizumab, αVβ6 antibody, STX-100, CTGF antibody, FG-3019, tipelukast, MN-001, aerosol pirfenidone or GP-101.