COMPOSITIONS AND METHODS FOR TREATING ISCHEMIC STROKE
The invention is directed to methods of treating ischemic stroke by adminis-tering a therapeutically effective amount of at least one compound of Formula I or Formula II to a subject in need thereof, wherein the compound has Formula I or Formula II: or a salt or ester of (I) or (II); wherein X is OH, C 1 -C 6 alkoxyl, 18 F, or 19 F; Y and Z are independently selected from C 1 -C 6 alkyl, C 1 -C 6 alkoxyl, halogen, substituted or unsubstituted C 1 -C 6 amine, 18 F, 19 F, or H; and n is 1, 2, or 3.
1 . A method of treating ischemic stroke comprising administering a therapeutically effective amount of at least one compound of Formula I or Formula II to a subject in need thereof, wherein the compound has Formula I or Formula II:
or a salt or ester of (I) or (II); wherein
X is OH, C 1 -C 6 alkoxyl, 18 F, or 19 F;
Y and Z are independently selected from C 1 -C 6 alkyl, C 1 -C 6 alkoxyl, halogen, substituted or unsubstituted C 1 -C 6 amine, 18 F, 19 F, or H; and
n is 1, 2, or 3.
2 . The method according to claim 1 , wherein X is 18 F, or 19 F; Y and Z are independently selected from C 1 -C 6 alkyl, C 1 -C 6 alkoxyl, halogen, 18 F, 19 F, or H; and n is 1, 2, or 3.
3 . The method according to claim 1 , wherein if in Formula I both Y and Z are H and n=1, then X is not OH.
4 . The method according to claim 1 further comprising administering at least one additional drug.
5 . The method according to claim 4 , wherein the additional drug is a mast cell inhibitor, anti-inflammatory drug, or vascular treatment drug.
6 . The method according to claim 4 , wherein the additional drug is ibuprofen.
7 . The method according to claim 4 , wherein the compound and the additional drug are administered either concurrently or consecutively.
8 . The method according to claim 1 , wherein the compound is cromolyn.
9 . The method according to claim 1 , wherein the compound is cromolyn sodium.
10 . The method according to claim 1 , wherein the compound is administered by inhalation.
11 . The method according to claim 10 , wherein the compound is micronized into particles having an average particle size of less than 10 microns.
12 . The method according to claim 10 , wherein the compound is micronized into particles having an average particle size less than 5 microns.
13 . The method according to claim 1 , wherein the compound is administered in an amount of about 5 to 20 mg.
14 . The method according to claim 1 , wherein the compound is administered in an amount of about 17.1 mg/kg.
15 . The method according to claim 1 , wherein the compound is administered twice daily.