METHODS FOR TREATING ALZHEIMER?S DISEASE AND RELATED DISORDERS
The invention is directed to a method of treating Alzheimer's Disease by administering to a subject in need thereof a therapeutically effective amount of cromolyn and optionally ibuprofen. The cromolyn may be in the form of cromolyn sodium and administered by inhalation.
1 . A method of treating Alzheimer's Disease comprising administering to a subject in need thereof a therapeutically effective amount of cromolyn.
2 . The method according to claim 1 , wherein the cromolyn is cromolyn sodium.
3 . The method according to claim 1 further comprising administering ibuprofen.
4 . The method according to claim 1 , wherein cromolyn is administered to 17.1 mg.
5 . The method according to claim 3 , wherein ibuprofen is administered in an amount of 10 mg.
6 . The method according to claim 1 , wherein the cromolyn is delivered orally, via inhaler, intravenously, intraperitoneally, or transdermally.
7 . The method according to claim 1 , wherein the effective amount of cromolyn decreased Aβ by about 10% to about 50% after one week of treatment.
8 . The method according to claim 1 , wherein the cromolyn is administered to achieve a cromolyn concentration in plasma of about 14-133 ng/ml.
9 . The method according to claim 1 , wherein the cromolyn is administered to achieve a cromolyn concentration in plasma of about 46 ng/ml.
10 . The method according to claim 8 , wherein the cromolyn concentration in plasma is achieved at about 6-60 minutes.
11 . The method according to claim 8 , wherein the cromolyn concentration in plasma is achieved in about 22 minutes.
12 . The method according to claim 1 , wherein the cromolyn achieves an average C max cromolyn concentration in the CSF of about 0.3 to about −04 ng/ml.
13 . The method according to claim 1 , wherein the cromolyn achieves an average C max cromolyn concentration in the CSF of about 0.24 ng/ml.
14 . The method according to claim 3 , wherein the ibuprofen achieves an average C max in the CSF of about 2.3 to 5.2 g/nl.
15 . The method according to claim 3 , wherein the ibuprofen achieves an average C max in the CSF of about 3.94 g/nl.
16 . The method according to claim 14 , wherein the ibuprofen C max is achieved in about 2-4 hours.
17 . The method according to claim 14 , wherein the ibuprofen C max is achieved in about 2.55 hours.
18 . The method according to claim 3 , wherein the ibuprofen achieves an average C max ibuprofen concentration in plasma of about 25 to about 1970 ng/ml.
19 . The method according to claim 3 , wherein the ibuprofen achieves an average C max ibuprofen concentration in plasma of about 1091 ng/ml.