Stable analogs of CYP450 lipid metabolites and inhibitors of soluble epoxide hydrolase
This disclosure relates to methods of reducing inflammation, angiogenesis, vascular leakage and neovascularization by administering to a subject in need thereof one or more stable analogs of CYP450 lipid metabolites (e.g., eicosanoids) and one or more inhibitors of a soluble epoxide hydrolase (sEH). This disclosure also relates to methods of treating disorders associated with inflammation, angiogenesis, vascular leakage and neovascularization by administering to a subject in need thereof one or more stable analogs of CYP450 lipid metabolites (e.g., eicosanoids) and one or more inhibitors of a soluble epoxide hydrolase (sEH). This disclosure further relates to pharmaceutical compositions and kits comprising at least one stable analog of CYP450 lipid metabolites (e.g., eicosanoids) and at least one inhibitor of a soluble epoxide hydrolase (sEH).
1. A method of treating or reducing the risk of an ophthalmological disorder associated with neovascularization, the method comprising administering to a subject in need thereof a therapeutically effective amount of an epoxydocosapentaenoic acid (EDP) or an epoxyeicosatetraenoic acid (EEQ), or a pharmaceutically acceptable salt thereof, and an effective amount of an inhibitor of a soluble epoxide hydrolase which is 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea having the following structure:
or a pharmaceutically acceptable salt thereof.
2. A method of treating or reducing the risk of an ophthalmological disorder associated with neovascularization, the method comprising administering to a subject in need thereof a therapeutically effective amount of:
an epoxymetabolite of a ω-3 long chain polyunsaturated fatty acid (LCPUFA) selected from the group consisting of:
or a pharmaceutically acceptable salt thereof, and
an inhibitor of a soluble epoxide hydrolase which is 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea having the following structure:
or a pharmaceutically acceptable salt thereof.