Water-soluble microneedle spicules and non-aqueous cosmetic composition containing the same
Disclosed herein are water-soluble microneedle spicules for scrubs and a non-aqueous cosmetic composition containing the same. More specifically, the present invention relates to water-soluble microneedle spicules for scrubs, which are in the shape of a triangular pyramid or sexangular pyramid and characterized in that at least any one among the interior angles of the pyramid base of the spicules for scrubs is 90 degrees or less; and a non-aqueous cosmetic composition containing the same. 10 110, 120, 130 : Separation 14 mixture: Gene Mixture 15 : Test Group : Control Group
1. A water-soluble, microneedle spicule of a quadrangular pyramidal shape comprising:
a vertex having an internal angle of 40 degrees or less;
a quadrilateral base that is a diamond shape or a parallelogram, wherein two interior angles of the quadrilateral base are less than 90 degrees;
a height from the quadrilateral base to the vertex that is 1.375 times to 10 times greater than a diagonal length of the quadrilateral base, wherein the height of microneedle spicule is 0.01 mm to 2 mm;
an empty inside;
a depression is formed on at least one surface of the microneedle spicule and a depth of the depression is less than ½ of the height of the microneedle spicule; and
a hyaluronic acid polymer which has a molecular weight of 0.1 kDa to 28 kDa.
2. The water-soluble, microneedle spicule of claim 1 , further comprising at least one material selected from the group consisting of polysaccharides, monosaccharides, oligosaccharides, polyvinyl alcohol, carboxyvinyl polymers, cellulose polymers, chitosan, salts, and a mixture thereof.
3. A composition comprising a plurality of particles, each comprising water-soluble, microneedle spicule of claim 1 .
4. A method of percutaneous delivery of a material, the method comprising:
applying, onto skin of a person, a composition comprising the water-soluble, microneedle spicule of claim 1 which contains the material; and
pressing the composition against the skin.
5. The method of claim 4 , wherein the material is selected from the group consisting of polypeptides, oligopeptides, DNA fragments, RNA fragments, antioxidants, insulin, growth hormones, and a mixture thereof.
6. The method of claim 4 , wherein the material is selected from the group consisting of human epidermal growth factor (EGF), fibroblast growth factor (FGF), vitamin C, vitamin E, and combinations thereof.
7. A composition, comprising:
a plurality of micro-spicules; and
a non-aqueous media mixed with a plurality of micro-spicules,
wherein at least part of the plurality of micro-spicules comprises the water-soluble, microneedle spicules of claim 1 .
8. The composition of claim 7 , wherein the micro-spicule comprises a physiologically active material selected from the group consisting of human epidermal growth factor (EGF), fibroblast growth factor (FGF), vitamin C, vitamin E, and combinations thereof.