Implantable objects, guiding devices, and methods of use thereof

1. A method of implanting an implantable object in a tooth socket of a subject, the method comprising:

(a) preparing the tooth socket by substantially removing the periodontal ligament;

(b) injecting an adhesive composition to the prepared tooth socket; and

(c) implanting the implantable object into the prepared tooth socket, wherein

(i) the shape of the implantable object is asymmetrical and matches the size, shape, or other dimension of the tooth socket;

(ii) the implantable object comprises a changing contour and is substantially free of a thread;

(iii) the adhesive composition comprises an aqueous medium, a powdered multivalent metal having a mean particle size between 0.005 mm and 0.150 mm, and an acidic compound of Formula (I):

or a pharmaceutically acceptable salt thereof, wherein:

L is O, S, NH, or CH 2 ;

each of R 1a and R 1b is independently H, optionally substituted alkyl, or optionally substituted aryl;

R 2 is H, NR 4a R 4b , C(O)R 5 , or C(O)OR 5 ;

R 3 is H, optionally substituted alkyl, or optionally substituted aryl;

each of R 4a and R 4a is independently H, C(O)R 6 , or optionally substituted alkyl;

R 5 is H, optionally substituted alkyl, or optionally substituted aryl;

R 6 is optionally substituted alkyl or optionally substituted aryl; and

each of x and y is independently 0, 1, 2, or 3;

(iv) the adhesive composition forms a tacky state after mixing with the aqueous medium;

(v) the adhesive composition is resorbable; and

(vi) upon adhering the implantable object to the tooth socket, the implantable object is load bearing.

2. The method of claim 1 , wherein the implantable object comprises a bone-engaging element.

3. The method of claim 1 , wherein the implantable object is custom produced.

4. The method of claim 1 , wherein the implantable object matches the size and/or shape of a tooth root.

5. The method of claim 1 , wherein the implantable object is between about 1 mm and about 10 mm in diameter.

6. The method of claim 1 , wherein the implantable object comprises a port or opening.

7. The method of claim 1 , wherein the implantable object and/or adhesive composition further comprise a naturally occurring polymer or a synthetic polymer.

8. The method of claim 1 , wherein the implantable object is configured for partial implantation in the bone.

9. The method of claim 1 , wherein the implantable object is configured for implantation fully in the bone.

10. The method of claim 1 , wherein placing the implantable object comprises a transition zone between an endosseous portion and a transdermal portion of the implantable object.

11. The method of claim 10 , wherein the implantable object comprises a geometry permitting variation in a thickness of the adhesive composition by about 0.8 to 1.2 mm.

12. The method of claim 10 , wherein the implantable object comprises a geometry permitting variation in a thickness of the adhesive composition by about 0.1 to 0.3 mm.

13. The method of claim 10 , wherein the implantable object comprises a geometry permitting variation in a thickness of the adhesive composition by more than 3.0 mm.

14. The method of claim 1 , further comprising using a guiding device in contact with a portion of the implantable object.

15. The method of claim 1 , wherein the implantable object is custom designed to be patient specific based on a scan, wherein the scan is one of a CT scan, an optical scan, or an MRI scan.

16. The method of claim 1 , wherein the implantable object comprises titanium or one or more ceramics.

17. The method of claim 1 , wherein the multivalent metal salt is selected from the group consisting of tetracalcium phosphate and tricalcium phosphate.

18. The method of claim 1 , wherein the implantable object has a load-bearing capacity of greater than about 0.5 MPa.

19. The method of claim 1 , wherein the adhesive composition further comprises an additive.