Geometric configurations for gastric residence systems

1. A gastric residence system for administration to a stomach of a patient, comprising:

a central elastomer component, wherein the central elastomer component is mono-concave, bi-concave, concavo-convex, or toroidal;

a plurality of at least three carrier polymer-agent components comprising a carrier polymer and a therapeutic agent or a salt thereof,

wherein each of the plurality of carrier polymer-agent components comprises an elongate member comprising a proximal end, a distal end, and an outer surface therebetween;

wherein the proximal end of each elongate member is attached to the central elastomer component and projects radially from the central elastomer component, each elongate member having the distal end not attached to the elastomer component and located at a larger radial distance from the central elastomer component than the proximal end;

wherein the central elastomer component is attached directly or indirectly to each elongate member by an intercomponent anchor, wherein the intercomponent anchor is a separate component from the central elastomer component and each of the elongate members;

wherein a first portion of each intercomponent anchor is located within the central elastomer component, and a second portion of each intercomponent anchor is located within:

a) a corresponding first segment of interfacing polymer, wherein each corresponding first segment of interfacing polymer is also attached directly or indirectly to a corresponding one of the elongate members;

b) a corresponding segment of linker, wherein each corresponding segment of linker is also attached directly or indirectly to a corresponding one of the elongate members; or

c) a corresponding one of the elongate members;

wherein

i) the central elastomer component is overmolded over the first portions of the intercomponent anchors, or

ii) the first segment of each interfacing polymer, a first segment of the corresponding segment of each linker, or a first segment of each elongate member is overmolded over the corresponding second portion of the intercomponent anchors;

wherein the gastric residence system has a compacted form when within a container that provides a constraining force, and is suitable for administration orally or through a feeding tube in the compacted form; and has an uncompacted form resulting from elastic recoil of the gastric residence system when released from the constraining force provided by the container in the stomach of the patient;

wherein the gastric residence system is configured to be retained in the stomach for a period of at least about 24 hours; and

wherein the gastric residence system is configured to release a therapeutically effective amount of the therapeutic agent or the salt thereof over at least a portion of the period in which the gastric residence system is retained in the stomach.

2. The gastric residence system of claim 1 , wherein the linker comprises hydroxypropyl methyl cellulose acetate succinate (HPMCAS) and polycaprolactone (PCL); or wherein the linker comprises poly(lactic-co-glycolic acid) (PLGA).

3. The gastric residence system of claim 2 , wherein the linker further comprises a plasticizer selected from the group consisting of triacetin, triethyl citrate, tributyl citrate, poloxamers, polyethylene glycol, polypropylene glycol, diethyl phthalate, dibutyl sebacate, glycerin, castor oil, acetyl triethyl citrate, acetyl tributyl citrate, polyethylene glycol monomethyl ether, sorbitol, sorbitan, a sorbitol-sorbitan mixture, and diacetylated monoglycerides.

4. The gastric residence system of claim 1 , wherein the central elastomer component is overmolded over the first portions of the intercomponent anchors.

5. The gastric residence system of claim 1 , wherein the first segment of each interfacing polymer, the first segment of the corresponding segment of each linker, or the first segment of each elongate member is overmolded over the corresponding second portion of the intercomponent anchors.

6. The gastric residence system of claim 1 , wherein a maximum folding force of the gastric residence system occurs when the elongate members are at an angle between about 0 degrees and about 70 degrees from a fully unfolded plane of the gastric residence system.

7. The gastric residence system of claim 1 , wherein the gastric residence system has an x-y bending force of at least about 0.2 newtons.

8. The gastric residence system of claim 1 , wherein the central elastomer component comprises a plurality of branches equal in number to the plurality of at least three carrier polymer-agent components, and the central elastomer component further comprises webbing between the plurality of branches.

9. The gastric residence system of claim 1 , wherein the second portion of each intercomponent anchor is located within the corresponding segment of linker, wherein each corresponding segment of linker is also attached directly or indirectly to a corresponding one of the elongate members.

10. The gastric residence system of claim 1 , wherein at least one of the first portion or the second portion of each intercomponent anchor comprises a knob shape, and the first portion is located within the central elastomer component.

11. A gastric residence system for administration to a stomach of a patient, comprising:

a central elastomer component, wherein the central elastomer component is mono-concave, bi-concave, concavo-convex, or toroidal;

a plurality of at least three carrier polymer-agent components comprising a carrier polymer and a therapeutic agent or a salt thereof,

wherein each of the plurality of carrier polymer-agent components comprises an elongate member comprising a proximal end, a distal end, and an outer surface therebetween;

wherein the proximal end of each elongate member is attached to the central elastomer component and projects radially from the central elastomer component, each elongate member having the distal end not attached to the elastomer component and located at a larger radial distance from the central elastomer component than the proximal end;

wherein the central elastomer component is attached directly or indirectly to each elongate member by an intercomponent anchor, wherein the intercomponent anchor is a separate component from the central elastomer component and each of the elongate members;

wherein at least one of a first portion or a second portion of each intercomponent anchor comprises a knob shape, and the first portion is located within the central elastomer component;

wherein the gastric residence system has a compacted form when within a container that provides a constraining force, and is suitable for administration orally or through a feeding tube in the compacted form; and has an uncompacted form resulting from elastic recoil of the gastric residence system when released from the constraining force provided by the container in the stomach of the patient;

wherein the gastric residence system is configured to be retained in the stomach for a period of at least about 24 hours; and

wherein the gastric residence system is configured to release a therapeutically effective amount of the therapeutic agent or the salt thereof over at least a portion of the period in which the gastric residence system is retained in the stomach.

12. The gastric residence system of claim 11 , wherein the second portion of each intercomponent anchor is located within:

a) a corresponding first segment of interfacing polymer, wherein each corresponding first segment of interfacing polymer is also attached directly or indirectly to a corresponding one of the elongate members;

b) a corresponding segment of linker, wherein each corresponding segment of linker is also attached directly or indirectly to a corresponding one of the elongate members; or

c) a corresponding one of the elongate members.

13. The gastric residence system of claim 12 , wherein the linker comprises hydroxypropyl methyl cellulose acetate succinate (HPMCAS) and polycaprolactone (PCL); or wherein the linker comprises poly(lactic-co-glycolic acid) (PLGA).

14. The gastric residence system of claim 13 , wherein the linker further comprises a plasticizer selected from the group consisting of triacetin, triethyl citrate, tributyl citrate, poloxamers, polyethylene glycol, polypropylene glycol, diethyl phthalate, dibutyl sebacate, glycerin, castor oil, acetyl triethyl citrate, acetyl tributyl citrate, polyethylene glycol monomethyl ether, sorbitol, sorbitan, a sorbitol-sorbitan mixture, and diacetylated monoglycerides.

15. The gastric residence system of claim 12 , wherein the central elastomer component is overmolded over the first portions of the intercomponent anchors.

16. The gastric residence system of claim 12 , wherein the first segment of each interfacing polymer, a first segment of the corresponding segment of each linker, or a first segment of each elongate member is overmolded over the corresponding second portion of the intercomponent anchors.

17. The gastric residence system of claim 11 , wherein a maximum folding force of the gastric residence system occurs when the elongate members are at an angle between about 0 degrees and about 70 degrees from a fully unfolded plane of the gastric residence system.

18. The gastric residence system of claim 11 , wherein the gastric residence system has an x-y bending force of at least about 0.2 newtons.

19. The gastric residence system of claim 11 , wherein the central elastomer component comprises a plurality of branches equal in number to the plurality of at least three carrier polymer-agent components, and the central elastomer component further comprises webbing between the plurality of branches.

20. The gastric residence system of claim 12 , wherein the second portion of each intercomponent anchor is located within a corresponding segment of linker, wherein each corresponding segment of linker is also attached directly or indirectly to a corresponding one of the elongate members.