Polymer/copper combination for targeted cancer therapy
Polymer/copper combinations that can selectively target and kill cancer cells are described. Materials can include the reaction product of a biocompatible hydrophilic polymer and pyridine-2-thiol containing monomer. The copolymer reaction product can include pyridine-2-thiol side groups pendant to the backbone via a disulfide linkage. The hydrophilic component can form the polymer backbone and/or can form hydrophilic pendant groups off of the backbone. Copper ions can be associated with the copolymer.
1. A polymer/copper combination comprising a biocompatible copolymer, the biocompatible copolymer comprising;
a first component, the first component containing an acrylamide or an acrylate, the first component comprising a hydrophilic portion;
a second component, the second component containing an acrylamide or an acrylate, the second component comprising pyridine-2-thiol groups, the pyridine-2-thiol groups being pendant to a backbone of the biocompatible copolymer via a disulfide linkage; and
the polymer/copper combination further comprising copper ions complexed with the biocompatible copolymer via chelation of the copper ions with the pyridines of the pyridine-2-thiol groups.
2. The polymer/copper combination of claim 1 , wherein the polymer/copper combination is in the form of a particle, the hydrophilic portion being primarily on an exterior surface of the particle.
3. The polymer/copper combination of claim 1 , the hydrophilic portion comprising hydrophilic groups pendant to the polymer backbone.
4. The polymer/copper combination of claim 3 , wherein the pendant hydrophilic groups comprise poly(ethylene glycol).
5. The polymer/copper combination of claim 4 , wherein the pendant hydrophilic groups comprise poly(ethylene glycol)methacrylate.
6. The polymer/copper combination of claim 1 , wherein the first component comprises poly(ethylene glycol), poly(N-isopropylacrylamide) (polyNIPAAm), poly(N-(2-hydroxypropyl)methacrylamide) (polyHPMA), poly(acrylic acid) (PAAc), poly(DL-lactic acid-co-glycolic acid) PLGA, or poly(L-histidine).
7. The polymer/copper combination of claim 1 , wherein the pyridine-2-thiol groups comprise (pyridine-2-thiol)ethyl acrylate, (pyridine-2-thiol)ethyl methacrylate, ethyl (2-(pyridin-2-yldisulfanyl)ethyl)carbonate, N-(2-(pyridin-2-yldisulfanyl)ethyl)methacrylamide, or N-(2-(pyridin-2-yldisulfanyl)ethyl)acrylamide.
8. The polymer/copper combination of claim 1 , the biocompatible copolymer further comprising functional groups pendant to the backbone via a disulfide linkage.
9. The polymer/copper combination of claim 8 , wherein the functional groups comprise a copper chelator.
10. The polymer/copper combination of claim 9 , wherein the copper chelator comprises polyhydroxy functionality.
11. A composition configured for administration to a subject comprising the polymer/copper combination of claim 1 .
12. The polymer/copper combination of claim 2 , wherein the particle is a self-assembled co-polymer particle.