IP Library › Granted Patent US 10,112,975
Granted Patent B2
US 10,112,975 · App. 15/785,675 · Granted Oct 30, 2018

Benzodiazepine dimers, conjugates thereof, and methods of making and using

Inventors: Yong Zhang (West Windsor, NJ); Ivar M. McDonald (East Haddam, CT); Naidu S. Chowdari (Sunnyvale, CA); Tram N. Huynh (Pennington, NJ); Robert M. Borzilleri (Carversville, PA); Sanjeev Gangwar (Foster City, CA)
Assignee: Briston-Myers Squibb Company
C07K5/06052
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Quick Facts
Patent No.
US 10,112,975
App. No.
15/785,675
Granted
Oct 30, 2018
Kind
B2
Abstract

Benzodiazepine dimers having a structure represented by wherein R 1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).

Claims (1)

1. A compound having a structure represented by formula (IIb-03):

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 25, 2018
From: ZHANG, YONG; MCDONALD, IVAR M.; CHOWDARI, NAIDU S.; HUYNH, TRAM N.; BORZILLERI, ROBERT M.; GANGWAR, SANJEEV
To: BRISTOL-MYERS SQUIBB COMPANY
Reel/Frame 046194/0149 →
Continuity (6)
Continuation 15587715 · May 5, 2017
Continuation 15351843 · Nov 15, 2016
Continuation 14994296 · Jan 13, 2016
Provisional Application 62103157 · Jan 14, 2015
Provisional Application 62215928 · Sep 9, 2015
Related Publication 20180079781A1 · Mar 22, 2018