Electronic neuromodulatory emulation of extra- and intra-aortic balloon pump counter-pulsation systems and methods
An implantable electronic neuromodulation system includes an implantable pulse generator comprising a controller and a memory. The memory is configured to store an emulated neurosensory signal representative of nerve traffic acquired from a patient equipped with an extra-aortic balloon pump counter-pulsation system or an intra-aortic balloon pump counter-pulsation system. A lead is coupled to the implantable pulse generator. At least one electrode is coupled to the lead. The at least one electrode is positionable in contact with or adjacent to at least one nerve that carries sensory information from baroreceptors. The controller is configured to stimulate the at least one nerve using the emulated neurosensory signal.
1. A system, comprising:
an implantable electronic neuromodulation system including an implantable pulse generator comprising a controller and a memory, the memory configured to store an emulated neurosensory signal representative of nerve traffic acquired from a patient equipped with an extra-aortic balloon pump counter-pulsation system or an intra-aortic balloon pump counter-pulsation system;
a lead coupled to the implantable pulse generator; and
at least one electrode coupled to the lead, wherein the at least one electrode is positionable in contact with or adjacent to at least one nerve that carries sensory information from baroreceptors;
wherein the controller is configured to stimulate the at least one nerve using the emulated neurosensory signal.
2. The system of claim 1 , wherein the at least one electrode is positionable in contact with or adjacent to a carotid sinus nerve.
3. The system of claim 1 , wherein the at least one electrode is positionable in contact with or adjacent to an aortic depressor nerve.
4. The system of claim 1 , comprising a plurality of electrodes respectively coupled to the lead, wherein the plurality of electrodes are positionable in contact with or adjacent to any combination of a left carotid sinus nerve, a right carotid sinus nerve, a left aortic depressor nerve, and a right aortic depressor nerve.
5. The system of claim 1 , wherein the emulated neurosensory signal is representative of traffic along a carotid sinus nerve.
6. The system of claim 1 , wherein the emulated neurosensory signal is representative of traffic along an aortic depressor nerve.
7. The system of claim 1 , wherein the emulated neurosensory signal represents a recording of the nerve traffic.
8. The system of claim 7 , wherein the emulated neurosensory signal is an amplitude-scaled version of the nerve traffic recording.
9. The system of claim 1 , wherein the emulated neurosensory signal represents a signal derived from a recording of the nerve traffic.
10. The system of claim 9 , wherein the derived signal is a time domain signal produced from an inverse of a mathematical transformation applied to the nerve traffic recording.
11. The system of claim 1 , comprising an implantable sensor coupled to the controller, the implantable sensor configured to sense cardiac activity, wherein the controller is configured to modify the emulated neurosensory signal in response to signals produced by the implantable sensor.
12. The system of claim 1 , further comprising an aortic balloon pump counter-pulsation system configured to operate cooperatively with the implantable electronic neuromodulation system.
13. A method, comprising:
storing, in an implantable electronic neuromodulation system, an emulated neurosensory signal representative of nerve traffic acquired from a patient equipped with an extra-aortic balloon pump counter-pulsation system or an intra-aortic balloon pump counter-pulsation system;
sensing occurrence of a diastolic phase of a patient's heart; and
stimulating, during the diastolic phase, at least one nerve that carries sensory information from baroreceptors using the emulated neurosensory signal.
14. The method of claim 13 , wherein the at least one nerve includes a carotid sinus nerve or an aortic depressor nerve.
15. The method of claim 13 , wherein stimulating comprises:
stimulating a carotid sinus nerve using a first emulated neurosensory signal; and
stimulating an aortic depressor nerve using a second emulated neurosensory signal.
16. The method of claim 13 , further comprising compressing, during the diastolic phase, an ascending aorta of the heart using an extra-aortic balloon pump counter-pulsation system or an intra-aortic balloon pump counter-pulsation system.
17. A system, comprising:
an implantable stimulation source including a controller configured to control delivery of electrical stimulation modeled to emulate an extra-aortic balloon pump counter-pulsation system or an intra-aortic balloon pump counter-pulsation system;
a lead coupled to the stimulation source; and
at least one electrode coupled to the lead, wherein the at least one electrode is positionable in contact with or adjacent to at least one nerve.
18. The system of claim 17 , wherein the at least one nerve includes a carotid sinus nerve or an aortic depressor nerve.
19. The system of claim 17 , comprising a first electrode and a second electrode respectively coupled to the lead, wherein:
the first electrode is positionable in contact with or adjacent to a carotid sinus nerve; and
the second electrode is positionable in contact with or adjacent to an aortic depressor nerve.
20. The system of claim 17 , further comprising an aortic balloon pump counter-pulsation system configured to operate cooperatively with the implantable stimulation source.