IP Library › Granted Patent US 11,464,788
Granted Patent B2
US 11,464,788 · App. 15/788,626 · Granted Oct 11, 2022

Oligomer-corticosteroid conjugates

Inventors: Wen Zhang (San Ramon, CA); Jennifer Riggs-Sauthier (Huntsville, AL); J. Milton Harris (Huntsville, AL); Michael D. Bentley (Huntsville, AL)
Assignee: Nektar Therapeutics
A61K31/573A61K47/59A61K47/60C07J41/0005
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Quick Facts
Patent No.
US 11,464,788
App. No.
15/788,626
Granted
Oct 11, 2022
Kind
B2
Abstract

The invention provides corticosteroids that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the corticosteroid not attached to the water-soluble oligomer.

Claims (7)

1. A compound having the structure:

wherein POLY is a poly(alkylene oxide) having a number of repeating monomers in the range of from 2 to 30.

2. The compound of claim 1 , wherein the poly(alkylene oxide) is a poly(ethylene oxide).

3. The compound of claim 1 , wherein the poly(alkylene oxide) has a number of repeating monomers in the range of from 2 to 10.

4. The compound of claim 1 , wherein the poly(alkylene oxide) includes an alkoxy or hydroxy end-capping moiety.

5. A composition comprising the compound of claim 1 and a pharmaceutically acceptable excipient.

6. A composition comprising the compound of claim 1 , wherein the compound is present in a dosage form.

Assignments (4)
RELEASE OF SECURITY INTEREST Recorded Apr 17, 2020
From: TC LENDING, LLC, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 053180/0009 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 23, 2019
From: ZHANG, WEN; RIGGS-SAUTHIER, JENNIFER; HARRIS, J. MILTON; BENTLEY, MICHAEL D.
To: NEKTAR THERAPEUTICS
Reel/Frame 049837/0013 →
CORRECTIVE ASSIGNMENT TO CORRECT THE APPLICATION NUMBER 15/835,115 PREVIOUSLY RECORDED AT REEL: 044515 FRAME: 0727. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Aug 10, 2018
From: NEKTAR THERAPEUTICS
To: TC LENDING, LLC, AS COLLATERAL AGENT
Reel/Frame 046762/0412 →
SECURITY INTEREST Recorded Jan 2, 2018
From: NEKTAR THERAPEUTICS
To: TC LENDING, LLC, AS COLLATERAL AGENT
Reel/Frame 044515/0727 →
Continuity (4)
Continuation 14315998 · Jun 26, 2014
Continuation 12680877
Provisional Application 60997835 · Oct 5, 2007
Related Publication 20180256599A1 · Sep 13, 2018