Combination comprising N-acetyl-L-cysteine and its use
A combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin, and a medical product or pharmaceutical composition comprising such combination, useful for the treatment of a variety of diseases and conditions is described. The combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin is also useful for cosmetic treatment of skin and as an antibacterial agent.
1. A medical product consisting of one or more excipients and active agents consisting of:
(i) N-acetyl-L-cysteine;
(ii) selenium in the form of selenomethionine; and
(iii) melatonin
and/or physiologically acceptable salts thereof.
2. The medical product of claim 1 , wherein components (i)-(iii) are provided as separate dosage units.
3. The medical product of claim 1 , wherein N-acetyl-L-cysteine is present at a concentration of 3-10 wt. %, selenomethionine is present at a concentration of 0.3-1 wt. %, and melatonin is present at a concentration of 0.01-0.2 wt. %.
4. The medical product of claim 3 , wherein N-acetyl-L-cysteine is present at a concentration of 5 wt. %, selenomethionine is present at a concentration of 0.5 wt. %, and melatonin is present at a concentration of 0.1 wt. %.
5. A medical device comprising the medical product of claim 1 .
6. The medical device of claim 5 , wherein the medical product is incorporated into a plastic material of the medical device.
7. A hydrogel coating comprising the medical product of claim 1 .
8. A medical device comprising the hydrogel coating of claim 7 .
9. The medical device of claim 8 , wherein the hydrogel coating is incorporated into a plastic material of the medical device.
10. A cosmetic product comprising the medical product of claim 1 .
11. An antibacterial agent comprising the medical product of claim 1 .
12. A dermatological product consisting of one or more dermatologically acceptable excipients and active agents consisting of:
(i) N-acetyl-L-cysteine;
(ii) selenium in the form of selenomethionine; and
(iii) melatonin
and/or physiologically acceptable salts thereof.
13. The dermatological product of claim 12 , wherein components (i)-(iii) are provided as separate dosage units.
14. The dermatological product of claim 12 , wherein N-acetyl-L-cysteine is present at a concentration of 3-10 wt. %, selenomethionine is present at a concentration of 0.3-1 wt. %, and melatonin is present at a concentration of 0.01-0.2 wt. %.
15. The dermatological product of claim 14 , wherein N-acetyl-L-cysteine is present at a concentration of 5 wt. %, selenomethionine is present at a concentration of 0.5 wt. %, and melatonin is present at a concentration of 0.1 wt. %.
16. The dermatological product of claim 12 , wherein the one or more dermatologically acceptable excipients comprise water, ceteareth 25 glyceryl stearate, tea stearate, cetearyl alcohol, caprylic/capric triglyceride, dimethicone, glyceryn hydrogenated polyisobutene, polysorbate 60, pentylene glycol, or vanilla.
17. A medical product consisting of one or more excipients and active agents consisting of:
(i) N-acetyl-L-cysteine;
(ii) selenium in the form of selenomethionine;
(iii) melatonin; and
(iv) dexamethasone
and/or physiologically acceptable salts thereof.
18. The medical product of claim 17 , wherein components (i)-(iii) are provided as separate dosage units.
19. A hydrogel coating comprising the medical product of claim 17 .
20. A medical device comprising the medical product of claim 17 .