IP Library › Granted Patent US 10,143,690
Granted Patent B2
US 10,143,690 · App. 15/791,951 · Granted Dec 4, 2018

Oligomer-opioid agonist conjugates

Inventors: Jennifer Riggs-Sauthier (Huntsville, AL); Bo-Liang Deng (San Ramon, CA); Timothy A. Riley (Worcester, MA)
Assignee: Nektar Therapeutics
A61K31/485A61K47/10
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Quick Facts
Patent No.
US 10,143,690
App. No.
15/791,951
Granted
Dec 4, 2018
Kind
B2
Abstract

The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.

Claims (7)

1. A method of preparing a compound of the following formula:

comprising reacting codeine with an activated sulfonate ester of methoxy-terminated poly(ethylene glycol):

wherein n is 1, 2, 3, 4, 5, 6, 7, or 9.

2. The method of claim 1 , wherein n is 3, 4, 5, 6, 7, or 9.

3. The method of claim 1 , wherein the reaction is carried out at a temperature from room temperature to 45° C.

4. The method of claim 1 , wherein the reaction is carried out in a mixture of toluene and DMF.

5. The method of claim 1 , wherein the reaction is carried out in the presence of NaH.

Assignments (9)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 9, 2023
From: INHERIS BIOPHARMA, INC.
To: NEKTAR THERAPEUTICS
Reel/Frame 062313/0501 →
RELEASE OF SECURITY INTEREST Recorded Apr 17, 2020
From: TC LENDING, LLC, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 053180/0009 →
RELEASE OF SECURITY INTEREST Recorded Apr 17, 2020
From: TC LENDING, LLC, AS COLLATERAL AGENT
To: INHERIS BIOPHARMA, INC.
Reel/Frame 052435/0062 →
CHANGE OF NAME Recorded Nov 15, 2019
From: INHERIS PHARMACEUTICALS, INC.
To: INHERIS BIOPHARMA, INC.
Reel/Frame 051038/0585 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 28, 2019
From: NEKTAR THERAPEUTICS
To: INHERIS PHARMACEUTICALS, INC.
Reel/Frame 050846/0461 →
SECURITY INTEREST Recorded Oct 28, 2019
From: INHERIS PHARMACEUTICALS, INC.
To: TC LENDING, LLC, AS COLLATERAL AGENT
Reel/Frame 050846/0940 →
CORRECTIVE ASSIGNMENT TO CORRECT THE APPLICATION NUMBER 15/835,115 PREVIOUSLY RECORDED AT REEL: 044515 FRAME: 0727. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Aug 10, 2018
From: NEKTAR THERAPEUTICS
To: TC LENDING, LLC, AS COLLATERAL AGENT
Reel/Frame 046762/0412 →
SECURITY INTEREST Recorded Jan 2, 2018
From: NEKTAR THERAPEUTICS
To: TC LENDING, LLC, AS COLLATERAL AGENT
Reel/Frame 044515/0727 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 9, 2017
From: RIGGS-SAUTHIER, JENNIFER; DENG, BO-LIANG; RILEY, TIMOTHY A.
To: NEKTAR THERAPEUTICS
Reel/Frame 044082/0299 →
Continuity (12)
Continuation 15341470 · Nov 2, 2016
Continuation 14959604 · Dec 4, 2015
Continuation 14581832 · Dec 23, 2014
Continuation 14032648 · Sep 20, 2013
Continuation 13386327
Continuation In Part 12558395 · Sep 11, 2009
Continuation In Part PCTUS2008003353 · Mar 12, 2008
Provisional Application 61350853 · Jun 2, 2010
Provisional Application 61227399 · Jul 21, 2009
Provisional Application 60906387 · Mar 12, 2007
Provisional Application 61192261 · Sep 16, 2008
Related Publication 20180256563A1 · Sep 13, 2018