Hydrobromide salt of an anti-HIV compound
View Patent ↗Solid dispersions and dosage forms comprising the hydrobromide salt of a diarylpyrimidine derivative, useful as an anti-HIV agent.
1. A solid dispersion comprising a compound of formula (I):
in a water-soluble polymer selected from hydroxypropylmethyl cellulose 2910 5 mPa·s and vitamin E TGPS, wherein the weight:weight ratio of the water-soluble polymer to the compound of formula (I) is about 10:1 or about 9:1.
2. The solid dispersion according to claim 1 , wherein the weight:weight ratio of the water-soluble polymer to the compound of formula (I) is about 9:1.
3. A dosage form comprising the solid dispersion of claim 1 .
4. The dosage form of claim 3 wherein the dosage form is selected from a tablet and a capsule.
5. The solid dispersion according to claim 1 obtainable by spray-drying.
6. The solid dispersion according to claim 5 , further containing microcrystalline cellulose.
7. The solid dispersion according to claim 1 , wherein the water-soluble polymer is hydroxypropylmethyl cellulose 2910 5 mPa·s.
8. The solid dispersion according to claim 1 , wherein the water-soluble polymer is vitamin E TGPS.
9. The solid dispersion according to claim 7 , wherein the weight:weight ratio of the water-soluble polymer to the compound of formula (I) is about 9:1.
10. The solid dispersion according to claim 8 , wherein the weight:weight ratio of the water-soluble polymer to the compound of formula (I) is about 9:1.
11. The dosage form of claim 3 , wherein the water-soluble polymer is hydroxypropylmethyl cellulose 2910 5 mPa·s.
12. The dosage form of claim 3 , wherein the water-soluble polymer is vitamin E TGPS.
13. The dosage form of claim 3 , wherein the weight:weight ratio of the water-soluble polymer to the compound of formula (I) is about 9:1.
14. The dosage form of claim 11 , wherein the weight:weight ratio of the water-soluble polymer to the compound of formula (I) is about 9:1.
15. The dosage form of claim 12 , wherein the weight:weight ratio of the water-soluble polymer to the compound of formula (I) is about 9:1.