Devices and methods using a pathological frequency in electrical stimulation for pain management

1. An electrical stimulation system, comprising:

an implantable control module configured and arranged for implantation in a body of a patient, wherein the control module is configured and arranged to provide electrical stimulation signals to an electrical stimulation lead coupled to the implantable control module for stimulation of patient tissue, wherein the implantable control module comprises

a processor configured and arranged to perform the following actions:

generating an electrical stimulation signal at a first frequency in a range of 4 to 8 Hz, wherein the electrical stimulation signal comprises a series of bursts at the first frequency, wherein each burst comprises a plurality of pulses within the burst and at a second frequency in a range from 1 kHz to 5 kHz; and

delivering the electrical stimulation signal to one or more selected electrodes of an electrical stimulation lead.

2. The electrical stimulation system of claim 1 , wherein the actions further comprise sensing a biosignal.

3. The electrical stimulation system of claim 2 , wherein the actions further comprise repeating the generating, delivering, and sensing actions based on an analysis of the biosignal.

4. The electrical stimulation system of claim 1 , further comprising a sensor in communication with the control module, wherein the actions further comprise sensing a biosignal using the sensor.

5. The electrical stimulation system of claim 1 , further comprising the electrical stimulation lead coupleable to the implantable control module and comprising a plurality of electrodes disposed along a distal end portion of the electrical stimulation lead.

6. The electrical stimulation system of claim 1 , wherein a temporal separation between bursts is individually selected based on a pre-determined distribution function based on the first frequency wherein the pre-determined distribution function indicates a relative likelihood that the burst will begin at a particular time.

7. The electrical stimulation system of claim 6 , wherein the pre-determined distribution function is a periodic repeating distribution function.

8. The electrical stimulation system of claim 6 , wherein the pre-determined distribution function is a sine distribution.

9. The electrical stimulation system of claim 6 , wherein the pre-determined distribution function is a normal distribution.

10. The electrical stimulation system of claim 6 , wherein the pre-determined distribution function is a distribution function that resets with each burst.

11. An electrical stimulation system, comprising:

an implantable control module configured and arranged for implantation in a body of a patient, wherein the control module is configured and arranged to provide electrical stimulation signals to an electrical stimulation lead coupled to the implantable control module for stimulation of patient tissue, wherein the implantable control module comprises

a processor configured and arranged to perform the following actions:

generating electrical stimulation pulses or pulse bursts with a temporal separation between pulses or pulse bursts is selected based on a pre-determined distribution function based on a pre-selected first frequency wherein the pre-determined distribution function indicates a relative likelihood that the pulse or pulse burst will begin at a particular time; and

delivering the electrical stimulation pulses or pulse bursts to one or more selected electrodes of an electrical stimulation lead.

12. The electrical stimulation system of claim 11 , wherein the pre-determined distribution function is a periodic repeating distribution function.

13. The electrical stimulation system of claim 11 , wherein the pre-determined distribution function is a sine distribution.

14. The electrical stimulation system of claim 11 , wherein the pre-determined distribution function is a normal distribution.

15. The electrical stimulation system of claim 11 , wherein the pre-determined distribution function is a distribution function that resets with each pulse or pulse burst.

16. The electrical stimulation system of claim 11 , further comprising a sensor in communication with the control module, wherein the actions further comprise sensing a biosignal using the sensor.

17. The electrical stimulation system of claim 11 , further comprising the electrical stimulation lead coupleable to the implantable control module and comprising a plurality of electrodes disposed along a distal end portion of the electrical stimulation lead.

18. An electrical stimulation system, comprising:

an implantable control module configured and arranged for implantation in a body of a patient, wherein the control module is configured and arranged to provide electrical stimulation signals to an electrical stimulation lead coupled to the implantable control module for stimulation of patient tissue, wherein the implantable control module comprises

a processor configured and arranged to perform the following actions:

generating an electrical stimulation signal, wherein the electrical stimulation signal comprises i) a continuous stimulation signal at a first frequency in a range of 4 to 8 Hz and ii) a brief burst of pulses during every period or half period of the continuous stimulation signal, wherein each brief burst of pulses comprises a plurality of pulses at a second frequency in a range from 500 Hz to 5 kHz; and

delivering the electrical stimulation signal to one or more selected electrodes of an electrical stimulation lead.

19. The electrical stimulation system of claim 18 , wherein the actions further comprise sensing a biosignal.

20. The electrical stimulation system of claim 19 , wherein the actions further comprise repeating the generating, delivering, and sensing actions based on an analysis of the biosignal.