Diagnosis and treatment of tissue

1. A system for treating tissue in a patient by a user comprising:

an optical probe having at least one light source configured to illuminate the tissue and at least one sensor for sensing reflected light from the tissue;

a spectrometer configured to analyze the reflected light producing spectroscopic data; and

a tissue classification system comprising at least one algorithm that correlates selected data of the spectroscopic data with a diagnosis classification indicative of tissue condition of the tissue based only on the selected data, wherein the tissue classification system provides the diagnosis classification to the user, and

wherein the tissue classification system includes an imaging system configured to provide the diagnosis classification to the user by correlating location of the tissue to a three-dimensional image of a portion of the patient's anatomy containing the tissue, generating a three-dimensional optical spectroscopic image showing the location and diagnosis classification of the tissue in relation to the three-dimensional image and displaying the three-dimensional optical spectroscopic image.

2. A system as in claim 1 , wherein the reflected light comprises Auto-Fluorescence Spectra (AFS) or Elastic Scattering Spectra (ESS).

3. A system as in claim 1 , wherein the selected data is derived from spectra of endogenous fluorophores including tryptophan, tyrosine, phenylalanine, collagen, elastin, FAD, flavins, NADH, NADPH, Vitamin A, Vitamin K, Vitamin D, pyridoxine, pyridoxamone, pyridoxal, pyridoxic acid, pyridoxal 5′-phosphate, Vitamin B12, phospholipids, lipofuscin, ceroid, porphyrins, tryptophan spectra and/or collagen spectra.

4. A system as in claim 1 , wherein the diagnosis classification comprises benign, malignant, abnormal, cancer, disease or calcified.

5. A system as in claim 1 , wherein the diagnosis classification comprises high grade disease or low grade disease.

6. A system as in claim 1 , wherein the optical probe includes a treatment device configured to allow therapeutic treatment to be delivered to the tissue by the treatment device while the optical probe is in position to sense the reflected light for the diagnosis classification.

7. A system as in claim 6 , wherein the treatment device is configured to deliver laser energy in a manner that provides laser ablation to the tissue.

8. A system as in claim 6 , wherein the treatment device is configured to provide photodynamic therapy to the tissue.

9. A system as in claim 8 , wherein the treatment device includes an LED at near infrared range to deliver near infrared light to the tissue.

10. A system as in claim 6 , wherein the treatment device is configured to provide brachytherapy therapy to the tissue.

11. A system as in claim 10 , wherein the treatment device includes a cannula configured to deliver a radioactive seed therethrough.

12. A system as in claim 6 , wherein the treatment device is configured to deliver ultrasound wave energy in a manner that provides high-intensity focused ultrasound therapy to the tissue.

13. A system as in claim 6 , wherein the treatment device includes a cryoneedle configured for providing cryoablation to the tissue.

14. A system as in claim 6 , wherein the treatment device includes two or more electrodes configured for passing AC or DC current across the tissue to achieve tissue ablation.

15. A system as in claim 6 , wherein the treatment device is configured to deliver RF energy in a manner that provides RF ablation to the tissue.

16. A system as in claim 6 , wherein the treatment device is configured to deliver high temperature vapor in a manner that shrinks the tissue as in vapor ablation.

17. A system as in claim 6 , wherein the treatment device is configured to deliver drugs or pharmaceutical agents to the tissue.

18. A method of treating tissue in a patient comprising:

illuminating the tissue with an optical probe, wherein the optical probe includes at least one sensor for sensing reflected light from the tissue and transmitting reflected light information to a spectrometer configured to analyze the reflected light producing spectroscopic data; and

receiving a diagnostic classification of the tissue from a tissue classification system, wherein the tissue classification system includes at least one algorithm that correlates selected data of the spectroscopic data with classification data to determine the diagnostic classification, wherein the classification is indicative of tissue condition based only on the selected data; and

wherein the tissue classification system includes an imaging system configured to provide the diagnostic classification to a user by correlating location of the tissue to a three-dimensional image of a portion of the patient's anatomy containing the tissue, generating a three-dimensional optical spectroscopic image showing the location and diagnostic classification of the tissue in relation to the three-dimensional image and displaying the three-dimensional optical spectroscopic image, and wherein receiving a diagnostic classification comprises viewing the three-dimensional optical spectroscopic image.

19. A method as in claim 18 , wherein the reflected light comprises Auto-Fluorescence Spectra (AFS) or Elastic Scattering Spectra (ESS).

20. A method as in claim 18 , wherein the selected data is derived from spectra of endogenous fluorophores including tryptophan, tyrosine, phenylalanine, collagen, elastin, FAD, flavins, NADH, NADPH, Vitamin A, Vitamin K, Vitamin D, pyridoxine, pyridoxamone, pyridoxal, pyridoxic acid, pyridoxal 5′-phosphate, Vitamin B12, phospholipids, lipofuscin, ceroid, porphyrins, tryptophan spectra and/or collagen spectra.

21. A method as in claim 18 , wherein the diagnostic classification comprises benign, malignant, abnormal, cancer, disease or calcified.

22. A method as in claim 18 , wherein the diagnostic classification comprises high grade disease or low grade disease.

23. A method as in claim 18 , further including treating the tissue with the use of the optical probe based on the received diagnostic classification.

24. A method as in claim 23 , wherein the optical probe includes a treatment device configured to deliver laser energy, and wherein treating the tissue comprises delivering the laser energy in a manner that provides laser ablation to the tissue.

25. A method as in claim 23 , wherein the optical probe includes a treatment device configured to deliver infrared light, and wherein treating the tissue comprises delivering the infrared light in a manner that provides photodynamic therapy to the tissue.

26. A method as in claim 23 , wherein the optical probe includes a treatment device configured to deliver at least one radioactive seed, and wherein treating the tissue comprises delivering the at least one radioactive seed to the tissue.

27. A method as in claim 23 , wherein the optical probe includes a treatment device configured to deliver ultrasound wave energy, and wherein treating the tissue comprises delivering the ultrasound wave energy in a manner that provides high-intensity focused ultrasound therapy to the tissue.

28. A method as in claim 23 , wherein the optical probe includes at least one cryoneedle, and wherein treating the tissue comprises providing cryoablation to the tissue with the use of the cryoneedle.

29. A method as in claim 23 , wherein the optical probe includes a treatment device including two or more electrodes configured for passing AC or DC current across the tissue, and wherein treating the tissue comprises passing the AC or DC current across the tissue with the use of the two or more electrodes to achieve tissue ablation.

30. A method as in claim 23 , wherein the optical probe includes a treatment device configured to deliver RF energy, and wherein treating the tissue comprises delivering the RF energy in a manner that provides RF ablation to the tissue.

31. A method as in claim 23 , wherein the optical probe includes a treatment device configure to deliver high temperature vapor, and wherein treating the tissue comprises delivering the high temperature vapor in a manner that shrinks the tissue as in vapor ablation.

32. A method as in claim 23 , wherein the optical probe includes a treatment device configured to deliver drugs or pharmaceutical agents, and wherein the treating the tissue comprises delivering the drugs or pharmaceutical agents to the tissue.