Neridronic acid for treating complex regional pain syndrome
Osteoclast inhibitors, such as neridronic acid, in an acid or a salt form can be used to treat or alleviate pain or related conditions, such as complex regional pain syndrome.
1. A method of treating complex regional pain syndrome comprising parenterally administering, in a single dose or in divided doses, about 5 mg to about 500 mg of neridronic acid in an acid or a salt form, to a human being suffering from complex regional pain syndrome.
2. The method of claim 1 , wherein the neridronic acid in an acid or a salt form is parenterally administered in at least two divided doses of about 10 mg to about 250 mg.
3. The method of claim 1 , wherein the neridronic acid in an acid or a salt form is parenterally administered in at least two divided doses of about 5 mg to about 200 mg.
4. The method of claim 1 , wherein the human being has severe pain in a limb.
5. The method of claim 4 , wherein the severe pain in the limb is accompanied by allodynia.
6. The method of claim 4 , wherein the severe pain in the limb is accompanied by hyperalgesia.
7. The method of claim 4 , wherein the severe pain in the limb is accompanied by edema.
8. The method of claim 4 , wherein the severe pain in the limb is accompanied by changes in skin blood flow.
9. The method of claim 4 , wherein the severe pain in the limb is accompanied by abnormal sudomotor activity.
10. The method of claim 1 , wherein the human being is suffering from complex regional pain syndrome type I.
11. The method of claim 1 , wherein the human being is suffering from complex regional pain syndrome type II.
12. A method of treating complex regional pain syndrome comprising parenterally administering, in a single dose or in divided doses, about 200 mg to about 500 mg of neridronic acid in an acid or a salt form, to a human being suffering from complex regional pain syndrome.
13. The method of claim 12 , wherein the neridronic acid in an acid or a salt form is parenterally administered in at least two divided doses.
14. The method of claim 12 , wherein the patient has severe pain in a limb.
15. The method of claim 14 , wherein the severe pain in the limb is accompanied by allodynia.
16. The method of claim 14 , wherein the severe pain in the limb is accompanied by hyperalgesia.
17. The method of claim 14 , wherein the severe pain in the limb is accompanied by edema.
18. The method of claim 14 , wherein the severe pain in the limb is accompanied by changes in skin blood flow.
19. The method of claim 14 , wherein the severe pain in the limb is accompanied by abnormal sudomotor activity.
20. The method of claim 12 , wherein the human being is suffering from complex regional pain syndrome type I.
21. The method of claim 12 , wherein the human being is suffering from complex regional pain syndrome type II.
22. A method of treating complex regional pain syndrome comprising parenterally administering, in a single dose or in divided doses, about 100 mg to about 500 mg of neridronic acid in an acid or a salt form, to a human being suffering from complex regional pain syndrome.
23. The method of claim 22 , wherein the neridronic acid in an acid or a salt form is parenterally administered in at least two divided doses.
24. The method of claim 22 , wherein the human being has severe pain in a limb.
25. The method of claim 24 , wherein the severe pain in the limb is accompanied by allodynia.
26. The method of claim 24 , wherein the severe pain in the limb is accompanied by hyperalgesia.
27. The method of claim 24 , wherein the severe pain in the limb is accompanied by edema.
28. The method of claim 24 , wherein the severe pain in the limb is accompanied by changes in skin blood flow.
29. The method of claim 24 , wherein the severe pain in the limb is accompanied by abnormal sudomotor activity.
30. The method of claim 22 , wherein the human being is suffering from complex regional pain syndrome type I.