IP Library Granted Patent US 10,788,479
Granted Patent B2
US 10,788,479 · App. 15/812,150 · Granted Sep 29, 2020

Automatic analyzer

Inventors: Akihisa Makino (Tokyo, JP); Keiko Yoshikawa (Tokyo, JP); Takeshi Yokokawa (Tokyo, JP)
Assignee: HITACHI HIGH-TECH CORPORATION
G01N33/4905G01N33/86G01N35/00663G01N35/025G01N35/1002G01N35/1016G01N2035/00346G01N2035/00376G01N2035/00386G01N2035/00425G01N2035/00435G01N2035/00673G01N2035/1048
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Quick Facts
Patent No.
US 10,788,479
App. No.
15/812,150
Granted
Sep 29, 2020
Kind
B2
Abstract

An automatic analyzer which realizes stable reagent heating and high dispensing accuracy includes a thermostat bath for controlling a reagent or a reaction solution in reaction cells arranged on a circumference of a reaction disk to have a constant temperature; a first reagent dispensing mechanism dispenses a reagent into the reaction cells; a photometer detects transmitted light or scattered light in the reaction cell; and a disposable reaction container for allowing the sample and the reagent to mix and react with each other. The analyzer also includes a second reagent dispensing mechanism with a reagent heating function which dispenses the reagent into the disposable reaction container; a coagulation time detection section; a reaction container temperature control block; a reagent dispensing syringe which is connected to the second reagent dispensing mechanism; and a fluid temperature control mechanism which controls the temperature of an internal fluid of the reagent dispensing syringe.

Claims (38)

1. An automatic analyzer comprising:

a reaction disk, on which reaction cells are arranged on the circumference thereof, and which alternately repeats rotating and stopping;

a sample dispensing mechanism which dispenses a sample into the reaction cells and into a disposable reaction container;

a first reagent dispensing mechanism which dispenses a reagent into the reaction cells;

a thermostat bath disposed around the reaction disk that is configured to heat the reagent or a reaction solution in the reaction cells to have a first constant temperature;

a light source to irradiate light towards the reaction disk;

a photometer which detects transmitted light or scattered light by irradiating the light onto the reaction solution in one of the reaction cells on the reaction disk;

a reaction container temperature control block which has a coagulation time detection section; and

a second reagent dispensing mechanism which dispenses the reagent from one of the reaction cells into the disposable reaction container at the coagulation time detection section, which includes a reagent dispensing syringe which is connected to the second reagent dispensing mechanism; and

a controller,

wherein the coagulation time detection section includes a light source and a photometer, which detects transmitted light or scattered light by irradiating light onto a reaction solution in the disposable reaction container disposed thereon,

wherein the reagent dispensing syringe connected to the second reagent dispensing mechanism includes a heater,

wherein the controller is programmed to:

control the thermostat bath to heat the reagent or a reaction solution in the reaction cells to the first constant temperature,

control the reaction container temperature control block to have a second constant temperature, and

control the heater of the reagent dispensing syringe which is connected to the second reagent dispensing mechanism to have a predetermined temperature,

wherein the predetermined temperature of the heater of the reagent dispensing syringe is greater than the first constant temperature of the thermostat bath and the second constant temperature of the reaction container control block.

2. The automatic analyzer according to claim 1 , wherein

the automatic analyzer further comprises a cover which covers the second reagent dispensing mechanism, a temperature sensor disposed inside the cover, and a fan which exhausts air inside the cover, and

the controller is programmed to, upon determining the temperature sensor detects a temperature higher than a predetermined threshold, drive the fan.

3. The automatic analyzer according to claim 2 , wherein

the controller is configured to control the temperature inside the cover and the temperature of the internal fluid to be the same temperature.

4. The automatic analyzer according to claim 1 , wherein

when the second reagent dispensing mechanism sucks the reagent from one of the reaction cells of the reaction disk, air in the reaction cell is sucked when sucking segmental air for separating the reagent and the internal fluid from each other at the time of sucking the reagent.

5. The automatic analyzer according to claim 4 , wherein

when the reagent is sucked, the reagent whose temperature is controlled in the reaction cell is sucked.

6. The automatic analyzer according to claim 1 , wherein

the automatic analyzer further comprises a heat block which has a through-hole capable of inserting a reagent dispensing probe of the second reagent dispensing mechanism therethrough, and is controlled to have a constant temperature, and

the reagent is discharged into the disposable reaction container such that the reagent dispensing probe is inserted into the through-hole.

7. The automatic analyzer according to claim 6 , wherein

when the second reagent dispensing mechanism sucks the reagent from one of the reaction cells of the reaction disk the reagent is sucked without inserting the reagent dispensing probe into the heat block.

8. The automatic analyzer according to claim 1 , wherein

the automatic analyzer further comprises a heat block which has a through-hole capable of inserting a reagent dispensing probe of the second reagent dispensing mechanism therethrough, and is controlled to have a constant temperature, and

the reagent is heated by the second reagent dispensing mechanism such that the reagent dispensing probe is inserted into the through-hole.

9. The automatic analyzer according to claim 8 , wherein

the reagent is discharged such that the reagent dispensing probe is inserted into the disposable reaction container disposed in the coagulation time detection section.

10. The automatic analyzer according to claim 1 , wherein

the heating of the reagent and the discharge of the reagent are performed by the second reagent dispensing mechanism such that the reagent dispensing probe is inserted into the disposable reaction container disposed in the coagulation time detection section.

Assignments (1)
CHANGE OF NAME AND ADDRESS Recorded Mar 30, 2020
From: HITACHI HIGH-TECHNOLOGIES CORPORATION
To: HITACHI HIGH-TECH CORPORATION
Reel/Frame 052259/0227 →