Granted Patent B2

US 10,307,611 · App. 15/816,238 · Granted Jun 4, 2019

Inventors: Zachary John Hambrecht Malchano (Boston, MA); Martin Warren Williams (San Francisco, CA)

Assignee: COGNITO THERAPEUTICS, INC.

A61N5/0622A61B5/04842A61B5/04845A61N1/36036A61N1/36082A61B5/4088A61N1/0551

Abstract

Claims (126)

1. A system for treating cognitive dysfunction in a subject in need thereof, comprising:

a light source;

a speaker;

a visual signaling component executed by a visual neural stimulation system and configured to provide, via the light source, visual stimulation having a first value of a first parameter;

an audio signaling component executed by an auditory neural stimulation system configured to provide, via the speaker, audio stimulation having a second value of the second parameter; and

a stimuli orchestration component executed by a neural stimulation orchestration system and configured to:

receive an indication of an ambient condition and an indication of a physiological condition of the subject;

select, for a first time interval, an offset between the visual stimulation and the audio stimulation to vary based on a policy and the indication of the ambient condition and the indication of the physiological condition of the subject, and

provide instructions to at least one of the visual neural stimulation system or the auditory neural stimulation system corresponding to the selected offset between the visual stimulation and the audio stimulation to vary to cause the at least one of the visual neural stimulation system or the auditory neural stimulation system to vary the offset between the visual stimulation and the audio stimulation.

2. The system of claim 1 , wherein the neural stimulation orchestration system is further configured to:

select, for a second time interval subsequent to the first time interval, one of the visual stimulation or the audio stimulation to vary based on the policy;

select, for the second time interval, the other of the visual stimulation or the audio stimulation to keep constant based on the policy; and

provide instructions to the visual neural stimulation system or the auditory neural stimulation system corresponding to the selected one of the visual stimulation or the audio stimulation to vary during the second time interval to cause the one of the visual neural stimulation system or the auditory neural stimulation system to vary the one of the visual stimulation or the audio stimulation during the second time interval.

3. The system of claim 1 , comprising:

a feedback monitor configured to detect the physiological condition of the subject during the first time interval,

wherein the neural stimulation orchestration system is further configured to select, using the policy and based on the detected physiological condition, one of the visual stimulation or the audio stimulation to vary during the first time interval.

4. The system of claim 1 , comprising:

a microphone configured to detect an ambient sound level; and

a photodiode configured to detect an ambient light level,

wherein the neural stimulation orchestration system is further configured to select, based on the ambient sound level and the ambient light level, one of the visual stimulation or the audio stimulation to vary during the first time interval.

5. The system of claim 1 , comprising:

an electrode to provide peripheral nerve stimulation to the subject, wherein

wherein the neural stimulation orchestration system is further configured to select, based on the policy, one of the visual stimulation, the audio stimulation, or the peripheral nerve stimulation to vary during a second time interval.

6. The system of claim 1 , wherein the visual stimulation is selected for varying during the first time interval, the system comprising:

an electrode to provide peripheral nerve stimulation to the subject during the first time interval; and

a feedback monitor configured to detect the physiological condition of the subject during the first time interval,

wherein the neural stimulation orchestration system is further configured to:

select, responsive to detecting the physiological condition, one of the audio stimulation or the peripheral nerve stimulation to vary during a second time interval subsequent to the first time interval;

select, for the second time interval, the visual stimulation to keep constant;

provide instructions to the visual neural stimulation system to keep constant during the second time interval;

provide instructions to the auditory neural stimulation system to vary during the second time interval; and

provide instructions to the electrode to keep constant during the second time interval.

7. The system of claim 1 , wherein the cognitive dysfunction comprises Alzheimer's disease.

8. The system of claim 1 , comprising:

a feedback monitor configured to detect the physiological condition of the subject during the first time interval,

wherein the neural stimulation orchestration system is further configured to:

select, responsive to detecting the physiological condition, the of the visual stimulation or the audio stimulation to vary during a second time interval subsequent to the first time interval;

select, for the second time interval, the other of the visual stimulation or the audio stimulation to keep constant; and

provide instructions to the visual neural stimulation system or the auditory neural stimulation system corresponding to the selected one of the visual stimulation or the audio stimulation to vary during the second time interval to cause the one of the visual neural stimulation system or the auditory neural stimulation system to vary the one of the visual stimulation or the audio stimulation during the second time interval.

9. A system for treating cognitive dysfunction in a subject in need thereof, comprising:

a visual neural stimulation system configured to provide, via a light output source, visual stimulation having a first value of a first parameter;

an auditory neural stimulation system configured to provide, via an audio output source, audio stimulation having a second value of the second parameter; and

a neural stimulation orchestration system configured to:

receive an indication of an ambient condition and an indication of a physiological condition of the subject;

select, for a first time interval, an offset between the visual stimulation and the audio stimulation to vary based on a policy and the indication of the ambient condition and the indication of the physiological condition of the subject, and

provide instructions to at least one of the visual neural stimulation system or the auditory neural stimulation system corresponding to the selected offset between the visual stimulation and the audio stimulation to vary to cause the at least one of the visual neural stimulation system or the auditory neural stimulation system to vary the offset between the visual stimulation and the audio stimulation.

10. The system of claim 9 , wherein the neural stimulation orchestration system is further configured to:

select, for a second time interval subsequent to the first time interval, one of the visual stimulation or the audio stimulation to vary based on the policy;

select, for the second time interval, the other of the visual stimulation or the audio stimulation to keep constant based on the policy; and

provide instructions to the visual neural stimulation system or the auditory neural stimulation system corresponding to the selected one of the visual stimulation or the audio stimulation to vary during the second time interval to cause the one of the visual neural stimulation system or the auditory neural stimulation system to vary the one of the visual stimulation or the audio stimulation during the second time interval.

11. The system of claim 9 , comprising:

a feedback monitor configured to detect the physiological condition of the subject during the first time interval,

wherein the neural stimulation orchestration system is further configured to select, using the policy and based on the detected physiological condition, one of the visual stimulation or the audio stimulation to vary during the first time interval.

12. The system of claim 9 , comprising:

a feedback monitor configured to detect the physiological condition of the subject during the first time interval,

wherein the neural stimulation orchestration system is further configured to:

select, responsive to detecting the physiological condition, one of the visual stimulation or the audio stimulation to vary during a second time interval subsequent to the first time interval;

select, for the second time interval, the other of the visual stimulation or the audio stimulation to keep constant; and

provide instructions to the visual neural stimulation system or the auditory neural stimulation system corresponding to the selected one of the visual stimulation or the audio stimulation to vary during the second time interval to cause the one of the visual neural stimulation system or the auditory neural stimulation system to vary the one of the visual stimulation or the audio stimulation during the second time interval.

13. The system of claim 9 , comprising:

a microphone configured to detect an ambient sound level; and

a photodiode configured to detect an ambient light level,

wherein the neural stimulation orchestration system is further configured to select, based on the ambient sound level and the ambient light level, one of the visual stimulation or the audio stimulation to vary during the first time interval.

14. The system of claim 9 , comprising:

an electrode to provide peripheral nerve stimulation to the subject,

wherein the neural stimulation orchestration system is further configured to select, based on the policy, one of the visual stimulation, the audio stimulation, or the peripheral nerve stimulation to vary during a second time interval.

15. The system of claim 9 , wherein the visual stimulation is selected for varying during the first time interval, the system comprising:

an electrode to provide peripheral nerve stimulation to the subject during the first time interval; and

a feedback monitor configured to detect the physiological condition of the subject during the first time interval,

wherein the neural stimulation orchestration system is further configured to:

select, responsive to detecting the physiological condition, one of the audio stimulation or the peripheral nerve stimulation to vary during a second time interval subsequent to the first time interval;

select, for the second time interval, the visual stimulation to keep constant;

provide instructions to the visual neural stimulation system to keep constant during the second time interval;

provide instructions to the auditory neural stimulation system to vary during the second time interval; and

provide instructions to the electrode to keep constant during the second time interval.

16. The system of claim 9 , wherein the cognitive dysfunction comprises Alzheimer's disease.

17. A system for treating cognitive dysfunction in a subject in need thereof, comprising:

a visual neural stimulation system;

an auditory neural stimulation system;

a neural stimulation orchestration system;

a light output source;

an audio output source; and

one or more processors configured to execute one or more programs to treat a subject in need of a treatment of a brain disease, the one or more programs including instructions for conducting a therapy session, the therapy session comprising:

providing, via the light output source, visual stimulation having a first value of a first parameter;

providing, via the audio output source, audio stimulation having a second value of the second parameter;

receiving an indication of an ambient condition and an indication of a physiological condition of the subject;

selecting, for a first time interval, an offset between the visual stimulation and the audio stimulation to vary based on a policy and the indication of the ambient condition and the indication of the physiological condition of the subject, and

providing instructions to at least one of the visual neural stimulation system or the auditory neural stimulation system corresponding to the selected offset between the visual stimulation and the audio stimulation to vary to cause the at least one of the visual neural stimulation system or the auditory neural stimulation system to vary the offset between the visual stimulation and the audio stimulation.

18. The system of claim 17 , wherein the therapy session comprises:

selecting, for a second time interval subsequent to the first time interval, the other of the visual stimulation or the audio stimulation to vary based on the policy;

selecting, for the second time interval, the other of the visual stimulation or the audio stimulation to keep constant based on the policy; and

providing instructions to the visual neural stimulation system or the auditory neural stimulation system corresponding to the selected one of the visual stimulation or the audio stimulation to vary during the second time interval to cause the one of the visual neural stimulation system or the auditory neural stimulation system to vary the one of the visual stimulation or the audio stimulation during the second time interval.

19. The system of claim 17 , wherein the therapy session comprises:

detecting the physiological condition of the subject during the first time interval,

selecting, using the policy and based on the detected physiological condition, one of the visual stimulation or the audio stimulation to vary during the first time interval.

20. The system of claim 17 , wherein the therapy session comprises:

detecting the physiological condition of the subject during the first time interval;

selecting, responsive to detecting the physiological condition, the other of the visual stimulation or the audio stimulation to vary during a second time interval subsequent to the first time interval;

selecting, for the second time interval, the other of the visual stimulation or the audio stimulation to keep constant; and

providing instructions to the visual neural stimulation system or the auditory neural stimulation system corresponding to the selected one of the visual stimulation or the audio stimulation to vary during the second time interval to cause the one of the visual neural stimulation system or the auditory neural stimulation system to vary the one of the visual stimulation or the audio stimulation during the second time interval.

21. The system of claim 17 , wherein the therapy session comprises:

detecting an ambient sound level;

detecting an ambient light level; and

selecting, based on the ambient sound level and the ambient light level, one of the visual stimulation or the audio stimulation to vary during the first time interval.

22. The system of claim 17 , wherein the therapy session comprises:

providing, via an electrode, peripheral nerve stimulation to the subject; and

selecting, based on the policy, one of the visual stimulation, the audio stimulation, or the peripheral nerve stimulation to vary during a second time interval.

23. The system of claim 17 , wherein the visual stimulation is selected for varying during the first time interval, the therapy session further comprising:

providing, via an electrode, peripheral nerve stimulation to the subject during the first time interval;

detecting the physiological condition of the subject during the first time interval;

selecting, responsive to detecting the physiological condition, one of the audio stimulation or the peripheral nerve stimulation to vary during a second time interval subsequent to the first time interval;

selecting, for the second time interval, the visual stimulation to keep constant;

providing instructions to the visual neural stimulation system to keep constant during the second time interval;

providing instructions to the auditory neural stimulation system to vary during the second time interval; and

providing instructions to the electrode to keep constant during the second time interval.

24. The system of claim 17 , wherein the cognitive dysfunction comprises Alzheimer's disease.

25. A method for treating cognitive dysfunction in a subject in need thereof, comprising administering a stimulus to the subject using a system comprising:

a light source;

a speaker;

a visual signaling component executed by a visual neural stimulation system and configured to provide, via the light source, visual stimulation having a first value of a first parameter;

an audio signaling component executed by an auditory neural stimulation system configured to provide, via the speaker, audio stimulation having a second value of the second parameter; and

a stimuli orchestration component executed by a neural stimulation orchestration system and configured to:

receive an indication of an ambient condition and an indication a physiological condition of the subject;

select, for a first time interval, an offset between the visual stimulation and the audio stimulation to vary based on a policy and the indication of the ambient condition and the indication of the physiological condition of the subject, and

provide instructions to at least one of the visual neural stimulation system or the auditory neural stimulation system corresponding to the selected offset between the visual stimulation and the audio stimulation to vary to cause the at least one of the visual neural stimulation system or the auditory neural stimulation system to vary the offset between the visual stimulation and the audio stimulation.

26. The method of claim 25 , wherein the cognitive dysfunction comprises Alzheimer's disease.

Assignments (2)

Continuity (12)

Cited By (12)

US 12,208,267 US 12,238,481 US 12,296,106 US 12,311,194 US 12,318,549 US 12,383,759 US 12,434,072 US 12,453,854 US 12,515,069 US 12,623,047 US 12,678,089 US 12,710,822