IP Library › Granted Patent US 12,208,267
Granted Patent B1
US 12,208,267 · App. 18/640,726 · Granted Jan 28, 2025

Blood flow enhancement therapy system

Inventors: Yossi Gross (Moshav Mazor, IL); Ofri Vaisman (Sunnyvale, CA)
A61N1/36114A61N1/0456A61N1/0546A61N1/0548A61N1/0558A61N1/3603A61N1/3987
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Quick Facts
Patent No.
US 12,208,267
App. No.
18/640,726
Granted
Jan 28, 2025
Kind
B1
Abstract

A sphenopalatine ganglion (SPG) stimulating device for stimulating an SPG of a patient is provided. The SPG stimulating device includes a sheath having a proximal end portion and a distal end portion, the distal end portion shaped to define at least one electrode opening. A nasal stabilizer is disposed around the sheath and configured to stabilize the sheath with respect to a nostril of a nose of the patient when the sheath is disposed within the nose. An electrode mount is slidably disposed within the sheath, and at least one electrode is coupled to the electrode mount and deployable out of the sheath through the at least one electrode opening to position the at least one electrode to stimulate the SPG. Other applications are also described.

Claims (81)

1. A sphenopalatine ganglion (SPG) stimulating device for stimulating an SPG of a patient, the device comprising:

a sheath having a proximal end portion and a distal end portion, the distal end portion shaped to define at least one electrode opening;

a nasal stabilizer disposed around the sheath and configured to stabilize the sheath with respect to a nostril of a nose of the patient when the sheath is disposed within the nose;

an electrode mount, slidably disposed within the sheath;

at least one electrode coupled to the electrode mount and deployable out of the sheath through the at least one electrode opening to position the at least one electrode to stimulate the SPG;

a control unit comprising a battery and circuitry and configured to drive the at least one electrode to stimulate the SPG; and

a sensor configured to sense a physiological response of the patient to stimulation of the SPG and to send to the control unit a signal indicative of the physiological response.

2. The device according to claim 1 , wherein the sheath is flexible.

3. The device according to claim 1 , wherein a distance between the nasal stabilizer and the at least one electrode opening is 4-8 cm.

4. The device according to claim 1 , wherein an outer diameter of the nasal stabilizer is 3-15 mm greater than an outer diameter of the sheath.

5. The device according to claim 1 , wherein an outer diameter of the sheath is 3-8 mm.

6. The device according to claim 1 , wherein the at least one electrode is configured to curve away from a central longitudinal axis of the sheath during deployment of the at least one electrode.

7. The device according to claim 1 , wherein the nasal stabilizer is connected to the sheath.

8. The device according to claim 1 , wherein the at least one electrode is arranged such that distal motion of the electrode mount with respect to the sheath deploys the at least one electrode out of the sheath through the at least one electrode opening.

9. The device according to claim 8 , wherein the nasal stabilizer is arranged to remain in a same location with respect to the sheath during the distal motion of the electrode mount with respect to the sheath.

10. The device according to claim 9 , further comprising a releasable post-deployment lock, configured to prevent sliding of the electrode mount within the sheath following the distal motion of the electrode mount with respect to the sheath.

11. The device according to claim 1 , wherein the at least one electrode is arranged such that proximal motion of the sheath with respect to the electrode mount deploys the at least one electrode out of the sheath through the at least one electrode opening.

12. The device according to claim 11 , wherein the sheath is arranged to slide proximally with respect to the nasal stabilizer during the proximal motion of the sheath with respect to the electrode mount.

13. The device according to claim 12 , wherein the sheath is shaped to define a longitudinal slit on a lateral side of the sheath, and wherein the nasal stabilizer is connected to the electrode mount through the longitudinal slit.

14. The device according to claim 1 , wherein the sensor is coupled to the sheath.

15. The device according to claim 14 , wherein the sensor is a Doppler flowmetry sensor.

16. The device according to claim 1 , wherein the sensor is coupled to the electrode mount, and wherein the sensor is a Doppler flowmetry sensor.

17. The device according to claim 1 , further comprising a camera coupled to the sheath and configured to facilitate navigation of the sheath toward the SPG.

18. The device according to claim 1 , further comprising a camera fixed to a distal end of the electrode mount, configured to facilitate navigation of the distal end of the electrode mount toward the SPG.

19. The device according to claim 1 , wherein the control unit is wearable.

20. The device according to claim 1 , wherein the at least one electrode comprises a plurality of electrodes, and wherein the control unit is configured to designate at least one of the plurality of electrodes to exclude from use for stimulating the SPG in response to the signal.

21. The device according to claim 1 , wherein the sensor is a Doppler flowmetry sensor, and wherein the Doppler flowmetry sensor is configured to be coupled to skin of the patient over a carotid artery of the patient.

22. A sphenopalatine ganglion (SPG) stimulating device for stimulating an SPG of a patient, the device comprising:

a sheath having a proximal end portion and a distal end portion, the distal end portion shaped to define at least one electrode opening;

a nasal stabilizer disposed around the sheath and configured to stabilize the sheath with respect to a nostril of a nose of the patient when the sheath is disposed within the nose;

an electrode mount, slidably disposed within the sheath; and

at least one electrode coupled to the electrode mount and deployable out of the sheath through the at least one electrode opening to position the at least one electrode to stimulate the SPG:

wherein a distance between the nasal stabilizer and the at least one electrode opening is 4-8 cm.

23. The device according to claim 22 , wherein the nasal stabilizer is connected to the sheath.

24. The device according to claim 22 , wherein the at least one electrode is arranged such that distal motion of the electrode mount with respect to the sheath deploys the at least one electrode out of the sheath through the at least one electrode opening.

25. The device according to claim 22 , wherein the at least one electrode is arranged such that proximal motion of the sheath with respect to the electrode mount deploys the at least one electrode out of the sheath through the at least one electrode opening.

26. A sphenopalatine ganglion (SPG) stimulating device for stimulating an SPG of a patient, the device comprising:

a sheath having a proximal end portion and a distal end portion, the distal end portion shaped to define at least one electrode opening;

a nasal stabilizer disposed around the sheath and configured to stabilize the sheath with respect to a nostril of a nose of the patient when the sheath is disposed within the nose;

an electrode mount, slidably disposed within the sheath; and

at least one electrode coupled to the electrode mount and deployable out of the sheath through the at least one electrode opening to position the at least one electrode to stimulate the SPG:

wherein an outer diameter of the nasal stabilizer is 3-15 mm greater than an outer diameter of the sheath.

27. The device according to claim 26 , wherein the nasal stabilizer is connected to the sheath.

28. The device according to claim 26 , wherein the at least one electrode is arranged such that distal motion of the electrode mount with respect to the sheath deploys the at least one electrode out of the sheath through the at least one electrode opening.

29. The device according to claim 26 , wherein the at least one electrode is arranged such that proximal motion of the sheath with respect to the electrode mount deploys the at least one electrode out of the sheath through the at least one electrode opening.

30. A sphenopalatine ganglion (SPG) stimulating device for stimulating an SPG of a patient, the device comprising:

a sheath having a proximal end portion and a distal end portion, the distal end portion shaped to define at least one electrode opening;

a nasal stabilizer disposed around the sheath and configured to stabilize the sheath with respect to a nostril of a nose of the patient when the sheath is disposed within the nose;

an electrode mount, slidably disposed within the sheath; and

at least one electrode coupled to the electrode mount and deployable out of the sheath through the at least one electrode opening to position the at least one electrode to stimulate the SPG:

wherein an outer diameter of the sheath is 3-8 mm.

31. The device according to claim 30 , wherein the nasal stabilizer is connected to the sheath.

32. The device according to claim 30 , wherein the at least one electrode is arranged such that distal motion of the electrode mount with respect to the sheath deploys the at least one electrode out of the sheath through the at least one electrode opening.

33. The device according to claim 30 , wherein the at least one electrode is arranged such that proximal motion of the sheath with respect to the electrode mount deploys the at least one electrode out of the sheath through the at least one electrode opening.

34. A sphenopalatine ganglion (SPG) stimulating device for stimulating an SPG of a patient, the device comprising:

a sheath having a proximal end portion and a distal end portion, the distal end portion shaped to define at least one electrode opening;

a nasal stabilizer disposed around the sheath and configured to stabilize the sheath with respect to a nostril of a nose of the patient when the sheath is disposed within the nose;

an electrode mount, slidably disposed within the sheath; and

at least one electrode coupled to the electrode mount and deployable out of the sheath through the at least one electrode opening to position the at least one electrode to stimulate the SPG:

wherein the at least one electrode is configured to curve away from a central longitudinal axis of the sheath during deployment of the at least one electrode.

35. The device according to claim 34 , wherein the nasal stabilizer is connected to the sheath.

36. The device according to claim 34 , wherein the at least one electrode is arranged such that distal motion of the electrode mount with respect to the sheath deploys the at least one electrode out of the sheath through the at least one electrode opening.

37. The device according to claim 34 , wherein the at least one electrode is arranged such that proximal motion of the sheath with respect to the electrode mount deploys the at least one electrode out of the sheath through the at least one electrode opening.

38. A sphenopalatine ganglion (SPG) stimulating device for stimulating an SPG of a patient, the device comprising:

a sheath having a proximal end portion and a distal end portion, the distal end portion shaped to define at least one electrode opening;

a nasal stabilizer disposed around the sheath and configured to stabilize the sheath with respect to a nostril of a nose of the patient when the sheath is disposed within the nose;

an electrode mount, slidably disposed within the sheath;

at least one electrode coupled to the electrode mount and deployable out of the sheath through the at least one electrode opening to position the at least one electrode to stimulate the SPG; and

a sensor coupled to the electrode mount and configured to sense a physiological response of the patient to stimulation of the SPG, wherein the sensor is a Doppler flowmetry sensor.

39. The device according to claim 38 , wherein the nasal stabilizer is connected to the sheath.

40. The device according to claim 38 , wherein the at least one electrode is arranged such that distal motion of the electrode mount with respect to the sheath deploys the at least one electrode out of the sheath through the at least one electrode opening.

41. The device according to claim 38 , wherein the at least one electrode is arranged such that proximal motion of the sheath with respect to the electrode mount deploys the at least one electrode out of the sheath through the at least one electrode opening.

42. A sphenopalatine ganglion (SPG) stimulating device for stimulating an SPG of a patient, the device comprising:

a sheath having a proximal end portion and a distal end portion, the distal end portion shaped to define at least one electrode opening;

a nasal stabilizer disposed around the sheath and configured to stabilize the sheath with respect to a nostril of a nose of the patient when the sheath is disposed within the nose;

an electrode mount, slidably disposed within the sheath;

at least one electrode coupled to the electrode mount and deployable out of the sheath through the at least one electrode opening to position the at least one electrode to stimulate the SPG; and

a control unit comprising a battery and circuitry and configured to drive the at least one electrode to stimulate the SPG, wherein the control unit is wearable.

43. The device according to claim 42 , wherein the nasal stabilizer is connected to the sheath.

44. The device according to claim 42 , wherein the at least one electrode is arranged such that distal motion of the electrode mount with respect to the sheath deploys the at least one electrode out of the sheath through the at least one electrode opening.

45. The device according to claim 42 , wherein the at least one electrode is arranged such that proximal motion of the sheath with respect to the electrode mount deploys the at least one electrode out of the sheath through the at least one electrode opening.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 6, 2025
From: GROSS, YOSSI; VAISMAN, OFRI
To: BRAINFLOW MEDICAL, INC.
Reel/Frame 069752/0639 →
References Cited (294)
US 4044774A · Corbin et al. · 1977 [cited by applicant]
US 4503863A · Katims · 1985 [cited by applicant]
US 5088977A · Sibalis · 1992 [cited by applicant]
US 5121754A · Mullett · 1992 [cited by applicant]
US 5433739A · Sluijter et al. · 1995 [cited by applicant]
US 5529574A · Frackelton · 1996 [cited by applicant]
US 5792100A · Shantha · 1998 [cited by applicant]
US 5911223A · Weaver et al. · 1999 [cited by applicant]
US 5938690A · Law et al. · 1999 [cited by applicant]
US 6041252A · Walker et al. · 2000 [cited by applicant]
US 6146380A · Racz et al. · 2000 [cited by applicant]
US 6161047A · King et al. · 2000 [cited by applicant]
US 6360750B1 · Gerber et al. · 2002 [cited by applicant]
US 6526318B1 · Ansarinia · 2003 [cited by applicant]
US 6567702B1 · Nekhendzy et al. · 2003 [cited by applicant]
US 6591138B1 · Fischell et al. · 2003 [cited by applicant]
US 6602248B1 · Sharps et al. · 2003 [cited by applicant]
US 6620155B2 · Underwood et al. · 2003 [cited by applicant]
US 6941172B2 · Nachum · 2005 [cited by applicant]
US 6997941B2 · Sharkey et al. · 2006 [cited by applicant]
US 7013177B1 · Whitehurst et al. · 2006 [cited by applicant]
US 7117033B2 · Shalev et al. · 2006 [cited by applicant]
US 7120489B2 · Shalev et al. · 2006 [cited by applicant]
US 7146209B2 · Gross et al. · 2006 [cited by applicant]
US 7217351B2 · Krumme · 2007 [cited by applicant]
US 7223227B2 · Pflueger · 2007 [cited by applicant]
US 7270659B2 · Ricart et al. · 2007 [cited by applicant]
US 7317947B2 · Wahlstrand et al. · 2008 [cited by applicant]
US 7398121B2 · Matsumura et al. · 2008 [cited by applicant]
US 7509171B2 · DiMauro · 2009 [cited by applicant]
US 7561919B2 · Shalev et al. · 2009 [cited by applicant]
US 7636597B2 · Gross et al. · 2009 [cited by applicant]
US 7640062B2 · Shalev · 2009 [cited by applicant]
US 7684859B2 · Shalev et al. · 2010 [cited by applicant]
US 7818063B2 · Wallace et al. · 2010 [cited by applicant]
US 7831306B2 · Finch et al. · 2010 [cited by applicant]
US 7860569B2 · Solberg et al. · 2010 [cited by applicant]
US 8055347B2 · Lamensdorf et al. · 2011 [cited by applicant]
US 8060207B2 · Wallace et al. · 2011 [cited by applicant]
US 8103350B2 · Wallace et al. · 2012 [cited by applicant]
US 8190248B2 · Besio et al. · 2012 [cited by applicant]
US 8287902B2 · Gross · 2012 [cited by applicant]
US 8353853B1 · Kyle et al. · 2013 [cited by applicant]
US 8457761B2 · Wariar · 2013 [cited by applicant]
US 8494641B2 · Boling et al. · 2013 [cited by applicant]
US 8577469B2 · Gross · 2013 [cited by applicant]
US 8676348B2 · Gross · 2014 [cited by applicant]
US 8731674B2 · Wallace et al. · 2014 [cited by applicant]
US 8954149B2 · Shalev · 2015 [cited by applicant]
US 9233245B2 · Lamensdorf et al. · 2016 [cited by applicant]
US 9433774B2 · Dar et al. · 2016 [cited by applicant]
US 9616221B2 · Gross · 2017 [cited by applicant]
US 9675796B2 · Dayan et al. · 2017 [cited by applicant]
US 9724513B2 · Lane et al. · 2017 [cited by applicant]
US 9724515B2 · Fostick et al. · 2017 [cited by applicant]
US 9731122B2 · Gross · 2017 [cited by applicant]
US 9775996B2 · Gross · 2017 [cited by applicant]
US 10271907B2 · Dayan et al. · 2019 [cited by applicant]
US 10279192B2 · Malchano et al. · 2019 [cited by applicant]
US 10293177B2 · Malchano et al. · 2019 [cited by applicant]
US 10307611B2 · Malchano et al. · 2019 [cited by applicant]
US 10398884B2 · Lad et al. · 2019 [cited by applicant]
US 10532204B2 · Gross · 2020 [cited by applicant]
US 10569086B2 · Fostick et al. · 2020 [cited by applicant]
US 10695557B1 · Townley et al. · 2020 [cited by applicant]
US 10758722B2 · Gross et al. · 2020 [cited by applicant]
US 10881858B1 · Gross et al. · 2021 [cited by applicant]
US 10898716B2 · Fostick et al. · 2021 [cited by applicant]
US 10994132B1 · Heldman et al. · 2021 [cited by applicant]
US 11027117B2 · Dar et al. · 2021 [cited by applicant]
US 11154710B2 · Belson et al. · 2021 [cited by applicant]
US 11202905B2 · Tendler et al. · 2021 [cited by applicant]
US 11376422B2 · Gross · 2022 [cited by applicant]
US 11413455B1 · Gross · 2022 [cited by applicant]
US 20020151948A1 · King et al. · 2002 [cited by applicant]
US 20020183683A1 · Lerner · 2002 [cited by applicant]
US 20030130707A1 · Gan et al. · 2003 [cited by applicant]
US 20030158589A1 · Katsnelson · 2003 [cited by applicant]
US 20030216792A1 · Levin et al. · 2003 [cited by applicant]
US 20030225331A1 · Diederich et al. · 2003 [cited by applicant]
US 20040002746A1 · Ryan et al. · 2004 [cited by applicant]
US 20040015068A1 · Shalev et al. · 2004 [cited by applicant]
US 20040019381A1 · Pflueger · 2004 [cited by applicant]
US 20040049134A1 · Tosaya et al. · 2004 [cited by applicant]
US 20040049180A1 · Sharps et al. · 2004 [cited by applicant]
US 20040116977A1 · Finch et al. · 2004 [cited by applicant]
US 20040210209A1 · Yeung et al. · 2004 [cited by applicant]
US 20040253304A1 · Gross et al. · 2004 [cited by applicant]
US 20050010205A1 · Hovda et al. · 2005 [cited by applicant]
US 20050021104A1 · DiLorenzo · 2005 [cited by applicant]
US 20050119650A1 · Sanders et al. · 2005 [cited by applicant]
US 20050137646A1 · Wallace et al. · 2005 [cited by applicant]
US 20050137647A1 · Wallace et al. · 2005 [cited by applicant]
US 20050159790A1 · Shalev · 2005 [cited by examiner]
US 20050187589A1 · Wallace et al. · 2005 [cited by applicant]
US 20050203599A1 · Garabedian et al. · 2005 [cited by applicant]
US 20050203600A1 · Wallace et al. · 2005 [cited by applicant]
US 20050203602A1 · Wallace et al. · 2005 [cited by applicant]
US 20050222647A1 · Wahlstrand et al. · 2005 [cited by applicant]
US 20050266099A1 · Shalev · 2005 [cited by applicant]
US 20050277996A1 · Podhajsky et al. · 2005 [cited by applicant]
US 20060030895A1 · Simon et al. · 2006 [cited by applicant]
US 20060095066A1 · Chang · 2006 [cited by examiner]
US 20060106430A1 · Fowler et al. · 2006 [cited by applicant]
US 20060224223A1 · Podhajsky et al. · 2006 [cited by applicant]
US 20060293723A1 · Whitehurst et al. · 2006 [cited by applicant]
US 20070000784A1 · Paul et al. · 2007 [cited by applicant]
US 20070073402A1 · Vresilovic et al. · 2007 [cited by applicant]
US 20070162086A1 · Dilorenzo · 2007 [cited by applicant]
US 20070213700A1 · Davison et al. · 2007 [cited by applicant]
US 20070233202A1 · Wallace et al. · 2007 [cited by applicant]
US 20070255338A1 · Wahlstrand · 2007 [cited by applicant]
US 20080009927A1 · Vilims · 2008 [cited by applicant]
US 20080033503A1 · Fowler et al. · 2008 [cited by applicant]
US 20080119907A1 · Stahmann · 2008 [cited by applicant]
US 20080260542A1 · Nishikawa et al. · 2008 [cited by applicant]
US 20080275430A1 · Belsky et al. · 2008 [cited by applicant]
US 20090112278A1 · Wingeier et al. · 2009 [cited by applicant]
US 20090125080A1 · Montgomery · 2009 [cited by applicant]
US 20090126813A1 · Yanagisawa et al. · 2009 [cited by applicant]
US 20090131850A1 · Geiger · 2009 [cited by applicant]
US 20090210026A1 · Solberg et al. · 2009 [cited by applicant]
US 20090299418A1 · Shalev et al. · 2009 [cited by applicant]
US 20090312816A1 · Gross · 2009 [cited by applicant]
US 20100114184A1 · Degtyar et al. · 2010 [cited by applicant]
US 20100185258A1 · Papay · 2010 [cited by applicant]
US 20100217369A1 · Gross · 2010 [cited by applicant]
US 20100324441A1 · Hargrove et al. · 2010 [cited by applicant]
US 20110046540A1 · Alterman et al. · 2011 [cited by applicant]
US 20110054518A1 · Carbunaru et al. · 2011 [cited by applicant]
US 20110160638A1 · Mauge et al. · 2011 [cited by applicant]
US 20110160797A1 · Makous et al. · 2011 [cited by applicant]
US 20120053659A1 · Molnar et al. · 2012 [cited by applicant]
US 20120071811A1 · Ansarinia · 2012 [cited by applicant]
US 20120203307A1 · Schroeppel et al. · 2012 [cited by applicant]
US 20120323214A1 · Shantha · 2012 [cited by applicant]
US 20130066392A1 · Simon et al. · 2013 [cited by applicant]
US 20130102952A1 · Gross · 2013 [cited by applicant]
US 20130150653A1 · Borsody · 2013 [cited by applicant]
US 20130166006A1 · Williams · 2013 [cited by applicant]
US 20130184803A1 · Altman · 2013 [cited by applicant]
US 20130289385A1 · Lozano et al. · 2013 [cited by applicant]
US 20140058189A1 · Stubbeman · 2014 [cited by applicant]
US 20140088672A1 · Bedenbaugh · 2014 [cited by applicant]
US 20140207224A1 · Simon · 2014 [cited by applicant]
US 20140257168A1 · Gill · 2014 [cited by applicant]
US 20140324128A1 · Gross · 2014 [cited by applicant]
US 20150011927A1 · Hua · 2015 [cited by applicant]
US 20150038948A1 · Ludvig et al. · 2015 [cited by applicant]
US 20150119898A1 · Desalles et al. · 2015 [cited by applicant]
US 20150174406A1 · Lamensdorf et al. · 2015 [cited by applicant]
US 20160331970A1 · Lozano · 2016 [cited by applicant]
US 20170007823A1 · Gross · 2017 [cited by applicant]
US 20170056642A1 · Moffitt et al. · 2017 [cited by applicant]
US 20170120053A1 · Fostick et al. · 2017 [cited by applicant]
US 20170182317A1 · Gross et al. · 2017 [cited by applicant]
US 20170296121A1 · Dar et al. · 2017 [cited by applicant]
US 20170296821A1 · Fostick et al. · 2017 [cited by applicant]
US 20180071523A1 · Gross et al. · 2018 [cited by applicant]
US 20180132947A1 · Dayan et al. · 2018 [cited by applicant]
US 20180193633A1 · Gross · 2018 [cited by applicant]
US 20180193646A1 · Fostick et al. · 2018 [cited by applicant]
US 20180318575A1 · Gross et al. · 2018 [cited by applicant]
US 20190009076A1 · Dayan et al. · 2019 [cited by applicant]
US 20190076653A1 · Fostick et al. · 2019 [cited by applicant]
US 20190282807A1 · Tendler et al. · 2019 [cited by applicant]
US 20190290908A1 · Hsu et al. · 2019 [cited by applicant]
US 20200100838A1 · Townley et al. · 2020 [cited by applicant]
US 20200171283A1 · Tal et al. · 2020 [cited by applicant]
US 20200222729A1 · Gertner et al. · 2020 [cited by applicant]
US 20200297238A1 · Tsui · 2020 [cited by applicant]
US 20220008746A1 · Malchano et al. · 2022 [cited by applicant]
US 20220288383A1 · Dar et al. · 2022 [cited by applicant]
US 20220331594A1 · Gross et al. · 2022 [cited by applicant]
US 20230022546A1 · Malchano et al. · 2023 [cited by applicant]
US 20230104621A1 · Malchano et al. · 2023 [cited by applicant]
US 20230111776A1 · Malchano et al. · 2023 [cited by applicant]
US 20230166072A1 · Malchano et al. · 2023 [cited by applicant]
US 20230233858A1 · Minar et al. · 2023 [cited by applicant]
US 20230381508A1 · Ludwig et al. · 2023 [cited by applicant]
JP 2004321242 · 2004 [cited by applicant]
JP 2007501067 · 2007 [cited by applicant]
WO 9405369 · 1994 [cited by applicant]
WO 0152931 · 2001 [cited by applicant]
WO 0185027 · 2001 [cited by applicant]
WO 2001085094 · 2001 [cited by applicant]
WO 2004044947A2 · 2004 [cited by applicant]
WO 2004045242 · 2004 [cited by applicant]
WO 2005011805 · 2005 [cited by applicant]
WO 2005030025A2 · 2005 [cited by applicant]
WO 2005030118A2 · 2005 [cited by applicant]
WO 2006090397 · 2006 [cited by applicant]
WO 2008007369 · 2008 [cited by applicant]
WO 2009137683A2 · 2009 [cited by applicant]
WO 2017006327 · 2017 [cited by applicant]
WO 2017072769 · 2017 [cited by applicant]
WO 2017115351 · 2017 [cited by applicant]
WO 2018051338 · 2018 [cited by applicant]
WO 2019175879A1 · 2019 [cited by applicant]
WO 2022056310A1 · 2022 [cited by applicant]
WO 2023225265A1 · 2023 [cited by applicant]
United States Office Action issued Dec. 13, 2023 in U.S. Appl. No. 18/229,379. [cited by applicant]
United States Office Action issued Feb. 15, 2024 in U.S. Appl. No. 18/229,379. [cited by applicant]
Karran September E et201 al., 1 “The Amyloid cascade hypothesis for AD,” Nature Reviews Drug Discovery, vol. 10; 698-712. [cited by applicant]
De La Torre JC, “Vascular Basis of Alzheimer's Pathogensis,” Ann NY Acad Sci. 977:196-215 (Nov. 2002). [cited by applicant]
Weller RO et al, “Perivascular Drainage of Amyloid-b Peptides from the Brain and Its Failure in Cerebral Amyloid Angiopathy and Alzheimer's Disease,” Brain Pathology 18 (Apr. 2008) 253-266. [cited by applicant]
Brief PubMed search for metal ions in Alzheimers. [cited by applicant]
An Office Action dated Sep. 27, 2016, which issued during the prosecution of U.S. Appl. No. 14/926,705. [cited by applicant]
U.S. Appl. No. 62/642,663, filed Mar. 14, 2018. [cited by applicant]
An International Search Report and a Written Opinion both dated Aug. 7, 2008, which issued during the prosecution of Applicant's PCT/IL2007/000865. [cited by applicant]
An Office Action dated Mar. 29, 2013, which issued during the prosecution of U.S. Appl. No. 12/373,306. [cited by applicant]
An Office Action dated Oct. 31, 2011, which issued during the prosecution of U.S. Appl. No. 12/373,306. [cited by applicant]
An Office Action dated Oct. 1, 2012, which issued during the prosecution of U.S. Appl. No. 12/373,306. [cited by applicant]
Notice of Allowance dated Jul. 24, 2013, which issued during the prosecution of U.S. Appl. No. 12/373,306. [cited by applicant]
An Office Action dated Apr. 11, 2013, which issued during the prosecution of U.S. Appl. No. 13/663,757. [cited by applicant]
Notice of Allowance dated Oct. 28, 2013, which issued during the prosecution of U.S. Appl. No. 13/663,757. [cited by applicant]
Elixmann IM et al., “In-vitro evaluation of a drainage catheter with integrated bioimpedance electrodes to determine ventricular size,” Biomed Tech 2013; 58 (Suppl. 1) Sep. 2013 (2 pages total). [cited by applicant]
An Office Action dated Aug. 31, 2015, which issued during the prosecution of U.S. Appl. No. 13/872,794. [cited by applicant]
An Applicant Initiated Interview Summary dated Dec. 14, 2015, which issued during the prosecution of U.S. Appl. No. 13/872,794. [cited by applicant]
An Office Action dated Feb. 3, 2016, which issued during the prosecution of U.S. Appl. No. 13/872,794. [cited by applicant]
Notice of Allowance dated Dec. 9, 2016, which issued during the prosecution of U.S. Appl. No. 14/794,739. [cited by applicant]
An Applicant Initiated Interview Summary dated Feb. 25, 2016, which issued during the prosecution of U.S. Appl. No. 13/872,794. [cited by applicant]
An Office Action dated Jun. 15, 2016, which issued during the prosecution of U.S. Appl. No. 13/872,794. [cited by applicant]
An International Search Report and a Written Opinion both dated Oct. 20, 2016, which issued during the prosecution of Applicant's PCT/IL2016/050728. [cited by applicant]
An Office Action dated Sep. 21, 2016, which issued during the prosecution of U.S. Appl. No. 14/794,739. [cited by applicant]
An International Search Report and a Written Opinion both dated Jan. 26, 2017, which issued during the prosecution of Applicant's PCT/IL2016/051161. [cited by applicant]
Notice of Allowance dated Jul. 14, 2017, which issued during the prosecution of U.S. Appl. No. 13/872,794. [cited by applicant]
An Office Action dated May 26, 2017, which issued during the prosecution of U.S. Appl. No. 15/453,290. [cited by applicant]
An International Preliminary Report on Patentability dated Apr. 7, 2009, which issued during the prosecution of Applicant's PCT/IL2007/000865. [cited by applicant]
Loutzenhiser, “Membrane Potential measurements in renal afferent and efferent arterioles: actions of Angiotensin II”, AJP—Renal Physiol Aug. 1, 1997 vol. 273 No. 2 F307-F314. [cited by applicant]
U.S. Appl. No. 60/830,717, filed Jul. 12, 2006. [cited by applicant]
Dao-Sheng Liu et al., “Activation of Na+ and K+ Pumping Modes of (Na,K)-ATPase by an Oscillating Electric Field,” The Journal of Biological Chemistry, vol. 265. No. 13, May 5, 1990. (pp. 7260-7267). [cited by applicant]
Robert F. Service.. “Electric fields deliver drugs into tumors.” http://news.sciencemaa.ora. Feb. 4, 2015. (5 Pages Total). [cited by applicant]
Vernengo J, “Injectable Bioadhesive Hydrogels for Nucleus Pulposus Replacement and Repair of the Damaged Intervertebral Disc: A Thesis,” Drexel University (Jan. 2007). [cited by applicant]
Urban JPG et al., “The nucleus of the intervertebral disc from development to degeneration,” American Zoologist 40(1): 53-61 (2000). [cited by applicant]
Cheung KMC et al., “Intervertebral disc regeneration by use of autologous mesenchymal stem cells, an experimental model in rabbits,” Abstract from the SRS 2004 Annual Meeting. [cited by applicant]
Freemont TJ et al., “Degeneration of intervertebral discs: current understanding of cellular and molecular events, and implications for novel therapies,” Expert Reviews in Molecular Biology, Mar. 29, 2001 (Cambridge Uni… [cited by applicant]
An Office Action dated Sep. 12, 2011, which issued during the prosecution of U.S. Appl. No. 12/373,306. [cited by applicant]
An Office Action dated Jul. 24, 2017, which issued during the prosecution of U.S. Appl. No. 14/982,187. [cited by applicant]
An International Search Report and a Written Opinion both dated Mar. 10, 2017, which issued during the prosecution of Applicant's PCT/IL2016/051363. [cited by applicant]
An Office Action dated Apr. 25, 2018, which issued during the prosecution of U.S. Appl. No. 15/637,330. [cited by applicant]
U.S. Appl. No. 62/444,939, filed Jan. 11, 2017. [cited by applicant]
An Office Action dated Jul. 10, 2019, which issued during the prosecution of U.S. Appl. No. 15/864,065. [cited by applicant]
An International Search Report and a Written Opinion both dated May 23, 2019, which issued during the prosecution of Applicant's PCT/IL2019/050284. [cited by applicant]
An Office Action dated Mar. 25, 2019, which issued during the prosecution of U.S. Appl. No. 15/742,245. [cited by applicant]
Borlase NM, “The thalamus in Parkinson's Disease,” Department of Psychology, University of Canterbury, 2012. [cited by applicant]
Fernandes J, “Protein May Prevent Neuron Death in Huntington's Patients, Study Finds,” huntingtonsdiseasenews.com, Jan. 19, 2017. [cited by applicant]
Lee H-J, “Extracellular asynuclein a novel and crucial factor in Lewy body diseases,” Nat. Rev. Neurol. 10, 92-98 (Feb. 2014); published online Jan. 28, 2014. [cited by applicant]
Starr PA et al., “Parkinson's Disease FAQ—Deep Brain Stimulation for Parkinson's Disease,” UCSF Apr. 19, 2017. [cited by applicant]
Perez RG et al., “A Role for Alpha-Synuclein in the Regulation of Dopamine Biosynthesis,” The Journal of Neuroscience, Apr. 15, 2002, 22(8):3090-3099. [cited by applicant]
Breydo L et al., “α-Synuclein misfolding and Parkinson's disease,” Biochimica et Biophysica Acta 1822 (2012) 261-285 (Available online Oct. 12, 2011). [cited by applicant]
Deleidi M et al., “Protein Clearance Mechanisms of Alpha-Synuclein and Amyloid-Beta in Lewy Body Disorders,” International Journal of Alzheimer's Disease, vol. 2012. [cited by applicant]
Xie L et al., “Sleep Drives Metabolite Clearance from the Adult Brain,” Science. Oct. 18, 2013; 342(6156). [cited by applicant]
Valdinocci D et al., “Potential Modes of Intercellular α-Synuclein Transmission,” International Journal of Molecular Sciences, Feb. 22, 2017. [cited by applicant]
U.S. Appl. No. 62/500,747, filed May 3, 2017. [cited by applicant]
An Office Action dated Jul. 29, 2019, which issued during the prosecution of U.S. Appl. No. 15/618,325. [cited by applicant]
Sawyer, P N et al. “Measurement of streaming potentials of mammalian blood vessels, aorta and vena cava, in vivo.” Biophysical journal vol. 6,5 (1966): 641-51. doi:10.1016/50006-3495(66)86683-3, https://www.ncbi.nlm.nih… [cited by applicant]
An Office Action dated Nov. 29, 2019, which issued during the prosecution of U.S. Appl. No. 15/969,411. [cited by applicant]
An Office Action dated Jan. 7, 2020, which issued during the prosecution of U.S. Appl. No. 15/618,325. [cited by applicant]
An Office Action dated Jan. 7, 2020, which issued during the prosecution of European Patent Application No. 16741703.9. [cited by applicant]
An Office Action dated Jan. 22, 2020, which issued during the prosecution of U.S. Appl. No. 15/771,551. [cited by applicant]
An Office Action dated Mar. 6, 2020, which issued during the prosecution of U.S. Appl. No. 15/618,325. [cited by applicant]
An Office Action together with the English Translation dated Aug. 19, 2020, which issued during the prosecution of Japanese Patent Application No. 2018-521586. [cited by applicant]
An Office Action dated Mar. 30, 2020, which issued during the prosecution of U.S. Appl. No. 16/574,772. [cited by applicant]
An Office Action dated Nov. 20, 2020, which issued during the prosecution of U.S. Appl. No. 16/353,407. [cited by applicant]
An International Search Report and a Written Opinion both dated Dec. 20, 2020, which issued during the prosecution of Applicant's PCT/IL2020/051022. [cited by applicant]
An Office Action dated Nov. 4, 2021, which issued during the prosecution of U.S. Appl. No. 16/713,660. [cited by applicant]
An Office Action dated Nov. 15, 2021, which issued during the prosecution of U.S. Appl. No. 16/692,528. [cited by applicant]
A Notice of Allowance dated Apr. 27, 2022, which issued during the prosecution of U.S. Appl. No. 17/667,051. [cited by applicant]
A Non-Final Office Action issued in U.S. Appl. No. 17/828,109, dated Apr. 12, 2023. [cited by applicant]
Austin SA, Santhanam AV, Hinton DJ, Choi DS, Katusic ZS. Endothelial nitric oxide deficiency promotes Alzheimer's disease pathology. J Neurochem. Dec. 2013;127(5):691-700. doi: 10.1111/jnc.12334. Epub Jun. 27, 2013. PMI… [cited by applicant]
Baker TS, Robeny J, Cruz D, Bruhat A, Iloreta AM, Costa A, Oxley TJ. Stimulating the Facial Nerve to Treat Ischemic Stroke: A Systematic Review. Front Neurol. Nov. 18, 2021;12:753182. [cited by applicant]
Benussi A, Cantoni V, Cotelli MS, Cotelli M, Brattini C, Datta A, Thomas C, Santarnecchi E, Pascual-Leone A, Borroni B. Exposure to gamma tACS in Alzheimer's disease: A randomized, double-blind, sham-controlled, crossov… [cited by applicant]
Chen J, Wang Z, Chen Q, Fu Y, Zheng K. Transcranial Direct Current Stimulation Enhances Cognitive Function in Patients with Mild Cognitive Impairment and Early/Mid Alzheimer's Disease: A Systematic Review and Meta-Analy… [cited by applicant]
Dhaynaut M, Sprugnoli G, Cappon D, Macone J, Sanchez JS, Normandin MD, Guehl NJ, Koch G, Paciorek R, Connor A, Press D, Johnson K, Pascual-Leone A, El Fakhri G, Santarnecchi E. Impact of 40 Hz Transcranial Alternating C… [cited by applicant]
Grossman N, Bono D, Dedic N, Kodandaramaiah SB, Rudenko A, Suk HJ, Cassara AM, Neufeld E, Kuster N, Tsai LH, Pascual-Leone A, Boyden ES. Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields. Cel… [cited by applicant]
Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai LH. Gamma frequency entrainment attenuates amylo… [cited by applicant]
Iturria-Medina, Y., Sotero, R., Toussaint, P et al. Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis. Nat Commun 7, 11934 (2016). [cited by applicant]
Jamali S, Ross B. Sustained changes in somatosensory gamma responses after brief vibrotactile stimulation. Neuroreport. May 7, 2014;25(7):537-41. [cited by applicant]
Khedr EM, Salama RH, Abdel Hameed M, Abo Elfetoh N, Seif P. Therapeutic Role of Transcranial Direct Current Stimulation in Alzheimer Disease Patients: Double-Blind, Placebo-Controlled Clinical Trial. Neurorehabil Neural… [cited by applicant]
Levi H, Schoknecht K, Prager O, Chassidim Y, Weissberg I, Serlin Y, Friedman A. Stimulation of the sphenopalatine ganglion induces reperfusion and blood-brain barrier protection in the photothrombotic stroke model. PLoS… [cited by applicant]
Liu Y, Liu S, Tang C, Tang K, Liu D, Chen M, Mao Z, Xia X. Transcranial alternating current stimulation combined with sound stimulation improves cognitive function in patients with Alzheimer's disease: Study protocol fo… [cited by applicant]
Liu Y, Tang C, Wei K, Liu D, Tang K, Chen M, Xia X, Mao Z. Transcranial alternating current stimulation combined with sound stimulation improves the cognitive function of patients with Alzheimer's disease: A case report… [cited by applicant]
Luo Y, Yang H, Yan X, Wu Y, Wei G, Wu X, Tian X, Xiong Y, Wu G, Wen H. Transcranial Direct Current Stimulation Alleviates Neurovascular Unit Dysfunction in Mice With Preclinical Alzheimer's Disease. Front Aging Neurosci… [cited by applicant]
Manippa V, Palmisano A, Nitsche MA, Filardi M, Vilella D, Logroscino G, Rivolta D. Cognitive and Neuropathophysiological Outcomes of Gamma-tACS in Dementia: A Systematic Review. Neuropsychol Rev. Mar. 6, 2023. doi: 10.1… [cited by applicant]
Martorell AJ, Paulson AL, Suk HJ, Abdurrob F, Drummond GT, Guan W, Young JZ, Kim DN, Kritskiy O, Barker SJ, Mangena V, Prince SM, Brown EN, Chung K, Boyden ES, Singer AC, Tsai LH. Multi-sensory Gamma Stimulation Amelior… [cited by applicant]
McDermott B, Porter E, Hughes D, McGinley B, Lang M, O'Halloran M, Jones M. Gamma Band Neural Stimulation in Humans and the Promise of a New Modality to Prevent and Treat Alzheimer's Disease. J Alzheimers Dis. 2018;65(2… [cited by applicant]
Saver JL, Kharaishvili N, Janelidze T, Beridze M, Zarqua N, Solberg Y, Bornstein NM; IMPACT-24M Trial Investigators. Refined Sphenopalatine Ganglion Stimulator Placement and Intensity Setting to Augment Blood Flow and N… [cited by applicant]
Suk HJ, Buie N, Xu G, Banerjee A, Boyden ES, Tsai LH. Vibrotactile stimulation at gamma frequency mitigates pathology related to neurodegeneration and improves motor function. Front Aging Neurosci. May 18, 2023;15:11295… [cited by applicant]
Talman WT, Nitschke Dragon D. Neuronal nitric oxide mediates cerebral vasodilatation during acute hypertension. Brain Res. Mar. 30, 2007;1139:126-32. doi: 10.1016/j.brainres.2007.01.008. Epub Jan. 8, 2007. [cited by applicant]
Wu L, Cao T, Li S, Yuan Y, Zhang W, Huang L, Cai C, Fan L, Li L, Wang J, Liu T, Wang J. Long-term gamma transcranial alternating current stimulation improves the memory function of mice with Alzheimer's disease. Front A… [cited by applicant]
Sangjun Lee, “Individually customized transcranial temporal interference stimulation for focused modulation of deep brain structures: a simulation study with different head models”, Scientific Reports, 2020, vol. 10, No… [cited by applicant]
United States Office Action issued Dec. 6, 2023 in U.S. Appl. No. 18/351,247. [cited by applicant]
“Sphenopalatine Ganglion (SPG) Block (Injection Technique),” DFW Pain Institute, PLLC DBA NorTex Spine & Joint Institute, https://www.nortexspineandjoint.com/sphenopalatine-ganglion-block/, Reviewed Jan. 30, 2023. [cited by applicant]
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US 12,343,526