Lipidated immune response modifier compound compositions, formulations, and methods
The compound N-(4-{[4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl]oxy}butyl)octadecanamide is a useful drug compound for enhancing immune response and can be used, for example, as a vaccine adjuvant and a cancer treatment.
1. A method of reducing tumor size by administering the compound N-(4-{[4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl]oxy}butyl)octadecanamide, or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the compound is administered directly into a localized tumor mass.
3. The method of claim 2 , wherein the tumor size is reduced by 30 to 100%.
4. The method of claim 3 , wherein the tumor size is reduced by 50 to 90%.
5. The method of claim 4 , wherein the tumor size is reduced by 60 to 80%.
6. The method of claim 5 , wherein the tumor size is reduced by 70%.
7. The method of claim 1 , wherein the tumor size is reduced by at least 90%.
8. A method of inducing an immune response in a localized tissue region by administering the compound N-(4-{[4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl]oxy}butyl)octadecanamide, or a pharmaceutically acceptable salt thereof.
9. The method of claim 8 , wherein the compound is administered directly into a localized tumor mass.