Powdered formulations of cromolyn sodium and ibuprofen

1. A composition suitable for inhalation comprising cromolyn sodium and ibuprofen, wherein the cromolyn sodium is micronized; the cromolyn sodium and ibuprofen are present in a weight ratio of 1:1-2; and the ibuprofen has been passed through a sieve of about 200 to 600 μm.

2. The composition according to claim 1 , wherein the ibuprofen is micronized.

3. The composition according to claim 1 , wherein the ibuprofen has a particle size of about 250 to 500 μm.

4. The composition according to claim 1 , wherein the ibuprofen has a particle size of about 300 to 400 μm.

5. The composition according to claim 1 , wherein the cromolyn sodium and ibuprofen are in powdered form.

6. A method of making a composition according to claim 1 , comprising micronizing cromolyn sodium, thereby forming micronized cromolyn sodium; separately sieving micronized cromolyn sodium and ibuprofen, thereby forming sieved cromolyn sodium and sieved ibuprofen; blending sieved cromolyn sodium and sieved ibuprofen, thereby forming blended cromolyn sodium and ibuprofen; and blend co-milling the blended cromolyn sodium and ibuprofen, thereby forming a composition of claim 1 .

7. The method according to claim 6 , wherein the sieve is a 300 to 400 μm sieve.

8. The method according to claim 6 , wherein the micronizing is performed with an air jet mill.

9. The method according to claim 8 , wherein the air jet mill has a feed gas pressure of about 45 psi and a grinding pressure of about 45 psi.

10. A method of treating Alzheimer's disease comprising administering a powdered composition according to claim 1 .

11. The method according to claim 10 , wherein the sieve is a 300 to 400 μm sieve.

12. The method according to claim 10 , wherein the ibuprofen has a particle size of about ≤3 μm.