Peptide
Provided are a novel peptide, a polynucleotide encoding the peptide, an expression vector including the polynucleotide, and a pharmaceutical composition including the peptide, a quasi-drug composition including the peptide, and a health functional food composition including the peptide.
1. A peptide comprising the amino acid sequence selected from the group consisting of SEQ ID NO: 1-86 and 88-95.
2. The peptide of claim 1 , wherein the peptide has a modification selected from the group consisting of an N- or C-terminal acetylation, amidation, or methylation; a D-amino acid introduction; a peptide bond modification selected from the group consisting of CH 2 —NH, CH 2 —S, CH 2 —S═O, and CH 2 —CH 2 ; a backbone modification; and a side-chain modification.
3. A polynucleotide encoding the peptide of claim 1 .
4. An expression vector comprising the polynucleotide of claim 3 .
5. A composition comprising the peptide of claim 1 .
6. The composition of claim 5 , comprising a polypeptide prepared by linking repeats of the peptide.
7. A composition comprising a complex of a peptide linked to a drug having a therapeutic effect on dentin or dental pulp diseases, wherein the peptide comprises any one amino acid sequence of SEQ ID NOS: 1 to 96.
8. The composition of claim 5 , which is a pharmaceutical composition and further comprises a pharmaceutically acceptable carrier, excipient, or diluent.
9. The composition of claim 7 , wherein the drug has a therapeutic effect on dentin hypersensitivity, pulp hyperemia, pulpitis, pulp degeneration or pulp necrosis, or gangrenous pulp.
10. The composition of claim 7 , wherein the composition is an oral antiseptic mouthwash, oral hygiene product, toothpaste, dental floss, or oral ointment.
11. A food product comprising the composition of claim 5 .
12. The food product of claim 11 , wherein the food is a beverage, tea, spice, gum or confectionery.
13. A peptide compound comprising repeats of a unit peptide, said unit peptide comprising any one amino acid sequence of SEQ ID NOS: 1 to 96.
14. The peptide compound of claim 13 , wherein the peptide has a modification selected from the group consisting of an N- or C-terminal acetylation, amidation, or methylation; a D-amino acid introduction; a peptide bond modification selected from the group consisting of CH 2 —NH, CH 2 —S, CH 2 —S═O, and CH 2 —CH 2 ; a backbone modification; and a side-chain modification.
15. A composition comprising the peptide compound of claim 13 .
16. A composition comprising a complex of a peptide compound of claim 13 linked to a drug having a therapeutic effect on dentin or dental pulp diseases.
17. The composition of claim 16 , wherein the drug has a therapeutic effect on dentin hypersensitivity, pulp hyperemia, pulpitis, pulp degeneration or pulp necrosis, or gangrenous pulp.
18. The composition of claim 16 , wherein the composition is an oral antiseptic mouthwash, oral hygiene product, toothpaste, dental floss, or oral ointment.
19. A food product comprising the composition of claim 15 .
20. The food product of claim 19 , wherein the food is a beverage, tea, spice, gum or confectionery.