Heterocyclic inhibitors of MCT4
Disclosed herein are compounds and compositions useful in the treatment of MCT4 mediated diseases, such as proliferative and inflammatory diseases, having the structure of Formula I: Methods of inhibition MCT4 activity in a human or animal subject are also provided.
1. A compound of structural formula
and/or a salt thereof.
2. A pharmaceutical composition comprising a compound as recited in claim 1 , and/or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant, or vehicle.
3. A method for inhibiting activity of the monocarboxylate transporter MCT4, in a biological sample comprising the step of contacting said biological sample with a compound as recited claim 1 , or a salt thereof.
4. A method for treating rheumatoid arthritis in a subject in need thereof, comprising the step of administering to said patient a compound as recited in claim 1 , or a pharmaceutically acceptable salt thereof.
5. The method as recited in claim 4 , wherein the subject is a human.