Gas depletion and gas addition devices for blood treatment
Devices for the preparation of depleted blood products that provide for the depletion of oxygen, carbon dioxide, or oxygen and carbon dioxide are described. In addition, devices for the replenishment of oxygen and other gases to an anaerobic blood product are described. Methods and systems incorporating depletion and addition devices are provided to optimize the preparation, storage and transfusion of blood products to a recipient are described.
1. A gas addition device for adding gas to a blood product comprising:
a. an enclosure;
b. one or more liquid chambers;
wherein said one or more liquid chambers further comprise one or more flow control features that disrupt laminar flow and wherein said one or more flow control features are half the height of said one or more liquid chambers and are the width of said one or more liquid chambers;
c. two or more gas addition chambers;
d. at least one gas permeable barrier separating at least one of said one or more liquid chambers from said two or more gas addition chambers;
e. at least one liquid inlet; and
f. at least one liquid outlet.
2. The gas addition device of claim 1 , wherein said gas permeable barrier is a membrane comprising a polyolefin, polytetrafluoroethylene (PTFE), polyvinylidene mono- or di-fluoride (PVDF), a polysulfone, a silicone, an epoxy, a polyester membrane, or a ceramic.
3. The gas addition device of claim 2 , wherein said at least one gas permeable barrier is a hydrophobic porous structure.
4. The gas addition device of claim 1 , wherein said one or more liquid chambers are separated from said two or more gas addition chambers by more than one gas permeable barrier.
5. The gas addition device of claim 1 , wherein said enclosure is prepared of a material selected from the group consisting of a rigid material, a flexible material, an elastic material, and combinations thereof.
6. The gas addition device of claim 1 , wherein said liquid chamber is prepared of a material selected from the group consisting of a rigid material, a flexible material, an elastic material, and combinations thereof.
7. The gas addition device of claim 1 , wherein said blood product is selected from the group consisting of whole blood, leukocyte depleted blood, leukocyte and platelet depleted blood, a red blood cell suspension, oxygen and carbon dioxide depleted red blood cells, oxygen depleted red blood cells, and plasma.
8. The gas addition device of claim 1 , wherein said two or more gas addition chambers further comprise at least one gas inlet and at least one gas outlet in fluid communication with said two or more gas addition chambers.
9. The gas addition device of claim 8 , wherein said gas addition chambers further comprise one or more gas flow control features.
10. The gas addition depletion device of claim 8 , wherein an addition gas flows into said at least one gas inlet, through said two or more gas addition chambers and out through said one or more gas outlets.
11. The gas addition device of claim 10 , wherein said addition gas is selected from the group consisting of pure oxygen, air, carbon dioxide, nitrous oxide and combinations thereof.
12. The gas addition device of claim 1 , wherein said one or more liquid chambers is selected from the group consisting of one liquid chamber, two liquid chambers, three liquid chambers, four liquid chambers, five liquid chambers, and more than five liquid chambers.
13. The gas addition device of claim 1 , wherein said two or more gas addition chambers is selected from the group consisting of two gas addition chambers, three gas addition chambers, four gas addition chambers, five gas addition chambers, and more than five gas addition chambers.
14. A method of preparing a blood product for transfusion comprising flowing a blood product liquid through a device according to claim 1 to prepare a blood product having an increased level of gas.
15. The method of claim 14 , wherein said blood product is selected from the group consisting of whole blood, leukocyte depleted blood, leukocyte and platelet depleted blood, a red blood cell suspension, oxygen and carbon dioxide depleted red blood cells, oxygen depleted red blood cells, and plasma.
16. The method of claim 14 , wherein said addition gas is selected from the group consisting of oxygen, carbon dioxide, nitric oxide, and combinations thereof.
17. The method of claim 14 , wherein said increased level of gas is a physiological level of oxygen bound to hemoglobin.
18. The method of claim 14 , wherein said blood product flows through a red blood cell editing device.
19. The method of claim 18 , wherein said blood product is selected from the group consisting of a red blood cell suspension and packed red blood cells.