Prevention of psychotic disorders and/or treatment of psychotic symptoms
The present invention relates to methods of preventing a psychotic disorder in a subject in need of intervention including administering to the subject a composition including EPA (eicosapentanoic acid) and DHA (docosahexaenoic acid). Methods of treating pre-psychotic symptoms in a subject, including administering to the subject a composition including EPA and DHA are also included.
1. A method of increasing functioning in a subject that meets the ultra high risk (UHR) criteria for developing a psychotic disorder including administering to the subject a composition including eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA) for one or more intervention periods, wherein each intervention period is 3 to 6 months; and wherein the functioning of the subject is assessed as increased after six months and/or after 12 months from commencing an intervention period and wherein functioning remains increased 9 months after an intervention period is ceased.
2. The method according to claim 1 , wherein the one or more intervention periods increases the functioning of the subject after six months and after 12 months from beginning an intervention period.
3. The method according to claim 1 , wherein the increase in functioning is assessed using the Global Assessment of Functioning (GAF).
4. The method according to claim 1 , wherein the subject at 12 months after commencing the administration functions at the equivalent of a 78.7 Global Assessment of Functioning (GAF) score.
5. The method according to claim 1 , wherein the increase in functioning is equivalent to an increase of 17.7 in Global Assessment of Functioning (GAF) score.
6. The method according to claim 1 , wherein the subject is between about 13 to 25 years of age.
7. The method according to claim 1 , wherein the EPA and DHA are present in the composition in a ratio of between 3:2 to 7:5 by weight.
8. The method according to claim 7 , wherein the EPA and DHA are in a concentration of more than 50% by weight of total fatty acids.
9. The method of claim 1 , wherein the composition is administered to the subject such that the subject is administered a dosage of 700 mg EPA and 480 mg DHA per day.
10. The method of claim 1 , wherein the total quantity dose of EPA and DHA administered per day is about 1.2 g.
11. The method according to claim 1 , wherein the method further prevents or delays the subject's experience of a first episode of psychosis or the development of a psychotic disorder in the subject.
12. The method according to claim 11 , wherein the psychotic disorder is schizophrenia, schizophreniform disorder, schizoaffective disorder, bipolar disorder with psychotic features or major depression with psychotic features.
13. The method of claim 1 , wherein the method further reduces the risk that the subject will transition to psychosis by at least 22.6%.
14. The method of claim 1 , wherein the method further reduces the severity of subthreshold manifestation of psychosis for at least 12 months after beginning an intervention period.
15. The method according to claim 1 , wherein the EPA and DHA are in triglyceride form.
16. The method according to claim 1 , wherein the composition is administered twice daily.
17. The method according to claim 1 , wherein the composition includes vitamin E.
18. The method according to claim 1 , wherein the intervention period is 6 months.
19. The method according to claim 1 , wherein the composition is the only composition administered to improve functioning.