Energy delivery systems and uses thereof
The present invention relates to comprehensive systems, devices and methods for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In certain embodiments, systems, devices, and methods are provided for delivering energy to difficult to access tissue regions (e.g. peripheral lung tissues), and/or reducing the amount of undesired heat given off during energy delivery.
1. A system comprising:
a) a primary catheter, wherein said primary catheter comprises a primary lumen;
b) a channel catheter, wherein said channel catheter is configured to fit within said primary lumen, and wherein said channel catheter comprises a channel lumen;
c) a steerable navigation catheter, wherein said steerable navigation catheter is configured to fit within said channel lumen, and wherein said steerable navigation catheter comprises a steerable tip and position sensing element; and
d) a microwave energy delivery device, wherein said microwave energy delivery device is configured to fit within said channel lumen, wherein the microwave energy delivery device comprises an inner conductor and an outer conductor,
the inner conductor comprises a proximal end and a distal end,
the outer conductor comprises a proximal end and a distal end,
the microwave energy delivery device is formed such that the coolant can circulate via the proximal end of the inner conductor, through a cooling channel of the inner conductor, out from a distal end of the inner conductor, via a region between the distal end of the inner conductor and the distal end of the outer conductor, through space which is formed in the outer conductor, and extends from the distal side of the outer conductor to a proximal side of the outer conductor, and via a region between the proximal end of the inner conductor and the proximal end of the outer conductor.
2. The system of claim 1 , wherein said primary catheter comprises a bronchoscope.
3. The system of claim 1 , further comprising a handle for manipulation of one or more of said primary catheter, said channel catheter, said steerable navigation catheter, and said energy delivery device.
4. The system of claim 1 , further comprising a processor capable of operating the components of said system.
5. The system of claim 1 , wherein said energy delivery device is capable of delivering microwave energy through said channel catheter.
6. The system of claim 1 , wherein:
the microwave energy delivery device is provided with a power rating, and
the microwave energy delivery device delivers an energy that exceeds the power rating.
7. The system of claim 1 , wherein the coolant is CO 2 .
8. The system of claim 1 , wherein the microwave energy delivery device has a sufficient length to extend from an oral cavity of a human subject, through a trachea of the human subject, and to a peripheral lung of the human subject.
9. The system of claim 1 , wherein the microwave energy delivery device has a diameter of 2 mm or less, and the microwave energy delivery device is flexible.
10. A method of placing an energy delivery device at a difficult to reach treatment site comprising:
a) providing the system of claim 1 , wherein said steerable navigation catheter is within the channel lumen, and said channel catheter is within said primary lumen;
b) inserting said primary catheter into an opening in a subject and directing said primary catheter towards said treatment site until further advance is constrained by the diameter of said primary catheter;
c) advancing said channel catheter beyond the distal end of said primary catheter and extending said channel catheter to said treatment site;
d) securing the distal end of said channel catheter at said treatment site;
e) withdrawing said steerable navigation catheter through said channel lumen and out the proximal end of said channel catheter;
f) inserting said energy delivery device through said channel lumen until the distal end of said energy delivery device reaches said treatment site.
11. The method of claim 10 , wherein said difficult to reach treatment site comprises the periphery of the lung.
12. The method of claim 11 , wherein said difficult to reach treatment site comprises a peripheral lung nodule.
13. The method of claim 12 , wherein said lung nodule is accessed through the bronchial tree.
14. A system comprising:
a) a primary catheter, wherein said primary catheter comprises a primary lumen;
b) a channel catheter, wherein said channel catheter is configured to fit within said primary lumen, and wherein said channel catheter comprises a channel lumen;
c) a steerable navigation catheter, wherein said steerable navigation catheter is configured to fit within said channel lumen, and wherein said steerable navigation catheter comprises a steerable tip and position sensing element; and
d) a microwave energy delivery device, wherein said microwave energy delivery device is configured to fit within said channel lumen, wherein the microwave energy delivery device comprises an inner conductor and an outer conductor,
the inner conductor comprises a proximal end and a distal end,
the outer conductor comprises a proximal end and a distal end,
the microwave energy delivery device is formed such that the coolant can circulate via the proximal end of the inner conductor, through a cooling channel of the inner conductor, out from a distal end of the inner conductor, via a region between the distal end of the inner conductor and the distal end of the outer conductor, through space which is formed in the outer conductor, and extends from the distal side of the outer conductor to a proximal side of the outer conductor, and via a region between the proximal end of the inner conductor and the proximal end of the outer conductor,
the microwave energy delivery device is provided with a power rating, and
the microwave energy delivery device delivers an energy that exceeds the power rating.
15. The system of claim 14 , wherein the coolant is CO 2 .