Heterocyclic compounds as immunomodulators
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
1. A compound, which is (R)-1-((7-cyano-2-(3′-(3-(((R)-3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-ylamino)-2,2′-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.
2. A compound, which is (S)-1-(7-cyano-2-(3′-(3-(((S)-3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-ylamino)-2,2′-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.
3. A compound, which is (R)-1-(7-cyano-2-(3′-(3-(((S)-3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-ylamino)-2,2′-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.
4. A compound, which is (S)-1-(7-cyano-2-(3′-(3-(((R)-3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-ylamino)-2,2′-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.
5. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients or carriers.
6. A pharmaceutical composition comprising a compound of claim 2 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients or carriers.
7. A pharmaceutical composition comprising a compound of claim 3 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients or carriers.
8. A pharmaceutical composition comprising a compound of claim 4 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients or carriers.
9. The compound of claim 1 , which is (R)-1-((7-cyano-2-(3′-(3-(((R)-3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-ylamino)-2,2′-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid.
10. The compound of claim 2 , which is (S)-1-((7-cyano-2-(3′-(3-(((S)-3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-ylamino)-2,2′-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid.
11. The compound of claim 3 , which is (R)-1-((7-cyano-2-(3′-(3-(((S)-3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-ylamino)-2,2′-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid.
12. The compound of claim 4 , which is (S)-1-((7-cyano-2-(3′-(3-(((R)-3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-ylamino)-2,2′-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid.
13. A pharmaceutical composition comprising a compound of claim 9 and one or more pharmaceutically acceptable excipients or carriers.
14. A pharmaceutical composition comprising a compound of claim 10 and one or more pharmaceutically acceptable excipients or carriers.
15. A pharmaceutical composition comprising a compound of claim 11 and one or more pharmaceutically acceptable excipients or carriers.
16. A pharmaceutical composition comprising a compound of claim 12 and one or more pharmaceutically acceptable excipients or carriers.