COMPOSITIONS COMPRISING PEROXYACID AND METHODS FOR PRODUCING AND USING THE SAME
The present invention provides methods for producing a non α-keto peracid that has lower toxicity and lower corrosivity. The present embodiments also provide methods and compositions for reducing microbes on a surface, methods, and compositions for preventing and reducing infectious vegetative bacteria on a substrate, and methods and compositions for treating a wound. In particular, compositions of the invention provide for a mixture of an α-keto peracid and a non α-keto peracid that works synergistically to reduce microbes on a surface, to prevent vegetative bacteria on a surface and to heal a wound in animals or humans.
1 . A composition comprising the products of a method comprising: contacting at least one first α-keto carboxylic acid with an oxidizing agent to form a mixture, and stirring the mixture at a temperature from −20° C. to 0° C.
2 . The composition of claim 1 further comprising a gel, a lotion, or an irrigation gel.
3 . The composition of claim 1 further comprising a liquid, a spray, or application granules.
4 . The composition of claim 1 , wherein the oxidizing agent is at least one agent selected from the group consisting of hydrogen peroxide, barium peroxide, sodium carbonate peroxide, calcium peroxide, sodium perborate, lithium peroxide, magnesium peroxide, strontium peroxide, zinc peroxide, potassium superoxide.
5 . The composition of claim 4 , wherein the oxidizing agent is hydrogen peroxide.
6 . The method of claim 1 , wherein the at least one first α-keto carboxylic acid is selected such that the at least one first peroxycarboxylic acid is selected from the group consisting of peroxypentanoic acid, peroxyhexanoic acid, peroxyheptanoic acid, peroxyoctanoic acid, peroxynonanoic acid, peroxydecanoic acid, peroxyundecanoic acid, peroxydodecanoic acid, the peroxyacids of the branched chain isomers of the foregoing.
7 . The composition of claim 1 , wherein the oxidizing agent and the α-keto carboxylic acid are at a ratio of 0.5:1 to 6:1.
8 . The composition of claim 7 , wherein the ratio is 2:1.
9 . The composition of claim 8 , wherein the method comprises a reaction time of 4 hours to 12 hours.
10 . The composition of claim 9 , wherein the reaction time is 10 hours to 12 hours.
11 . The composition of claim 1 , wherein the method comprises a reaction time of 4 hours to 12 hours.
12 . The composition of claim 11 , wherein the reaction time is 10 hours to 12 hours.
13 . The composition of claim 1 , wherein contacting further comprises contacting at least one second α-keto carboxylic acid with the oxidizer, and the mixture comprises the at least one first α-keto carboxylic acid, the at least one second carboxylic acid, and the oxidizer, and the non-α-keto peracids further comprise at least one second percarboxylic acid.
14 . The composition of claim 13 , wherein the at least one first α-keto carboxylic acid are chosen such that the at least one first peroxycarboxylic acid is selected from the group consisting of peroxypentanoic acid, peroxyhexanoic acid, peroxyheptanoic acid, peroxyoctanoic acid, peroxynonanoic acid, peroxydecanoic acid, peroxyundecanoic acid, peroxydodecanoic acid, and the branched chain isomers of the foregoing, and the at least one second α-keto carboxylic acid are chosen such that the at least one second peroxycarboxylic acid is selected from the group consisting of peroxylactic acid, peroxymaleic acid, peroxyascorbic acid, peroxyoxalic acid, peroxymalonic acid, peroxyglutaric acid, peroxyadipic acid, peroxypimelic acid, and peroxysuberic acid.
15 . The composition of claim 14 , wherein the at least one second peroxycarboxylic acid is selected from the group consisting of peroxylactic acid, peroxyascorbic acid, peroxyglutaric acid, peroxypimelic acid, and peroxysuberic acid.
16 . The composition of claim 14 , wherein the at least one second peroxycarboxylic acid comprises peroxymaleic acid.