Therapeutic compounds
The invention provides compounds and compositions that are useful for treating conditions including Alzheimer's disease, Parkinson's disease, diabetes, cancer, and psychotic disorders such as schizophrenia.
1. A method for treating disease in an animal comprising administering a compound of formulae II to the animal, wherein the compound of formulae II is:
where:
X is N, Y is CH and Z is N;
X is N, Y is CH and Z is CH;
X is N, Y is N and Z is CH;
X is CH, Y is CH and Z is CH;
R 2 is H or methyl; and
R 3 is ethyl that is optionally substituted with one or more groups independently selected from F, Cl, and Br; wherein the ring containing X, Y, and Z is optionally substituted on carbon with one or more groups independently selected from halo;
or a pharmaceutically acceptable salt thereof;
provided the compound is not:
wherein the disease is Alzheimer's disease, Parkinson's disease, diabetes, cancer, or a psychotic disorder.
2. The method of claim 1 wherein the compound of formulae II is selected from formula IIa, IIb, and IIc:
wherein:
R 2 is H or methyl; and
R 3 is ethyl that is optionally substituted with one or more groups independently selected from F, Cl, and Br;
or a pharmaceutically acceptable salt thereof.
3. The method of claim 1 wherein the compound of formulae II is selected from formulae IIc:
wherein:
R 2 is H or methyl; and
R 3 is ethyl that is optionally substituted with one or more groups independently selected from F, Cl, and Br;
or a pharmaceutically acceptable salt thereof.
4. The method of claim 1 wherein the compound of formulae II is selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
5. The method of claim 1 wherein the compound of formulae II is selected from formulae IIa and IIc:
wherein:
R 2 is H or methyl; and
R 3 is ethyl that is optionally substituted with one or more groups independently selected from F, Cl, and Br;
or a pharmaceutically acceptable salt thereof.
6. The method of claim 1 wherein the compound of formulae II is
or a pharmaceutically acceptable salt thereof.
7. The method of claim 1 wherein the compound of formulae II is selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
8. The method of claim 1 wherein the compound of formulae II is selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
9. A method for treating disease in an animal comprising administering a compound to the animal, wherein the compound is selected from the group consisting of:
or a pharmaceutically acceptable salt thereof;
wherein the disease is Alzheimer's disease, Parkinson's disease, diabetes, cancer, or a psychotic disorder.