BENDAMUSTINE DERIVATIVES AND METHODS OF USING SAME
The present invention is directed to bendamustine esters and bendamustine amides and their use for the treatment of cancer.
1 . (canceled)
2 . A method of treating cancer in a patient, the method comprising administering to said patient a pharmaceutical composition, wherein said pharmaceutical composition comprises:
(a) a compound of formula (II)
wherein R 2 is C 1 -C 24 alkylene and R 3 is —COOC 1-3 alkyl; or R 2 -R 3 is C 8 C 24 alkyl, or a pharmaceutically acceptable salt thereof; and
(b) a means for increasing the circulation time of the compound of formula (II), or a pharmaceutically acceptable salt thereof, in an aqueous environment.
3 . The method according to claim 2 , wherein said cancer is in the form of a solid tumor or a liquid tumor.
4 . The method according to claim 3 , wherein said cancer is in the form of a solid tumor.
5 . The method according to claim 4 , wherein said cancer is sarcoma, bladder cancer, cervical cancer, testicular cancer, melanoma, glioblastoma, colon cancer, head and neck cancer, ovarian cancer, prostate cancer, breast cancer, or lung cancer.
6 . The method according to claim 3 , wherein said cancer is in the form of a liquid tumor.
7 . The method according to claim 6 , wherein said cancer is lymphocytic leukemia, Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, or acute lymphocytic leukemia.
8 . The method according to claim 2 , wherein in the compound of formula (II) R 2 -R 3 is C 10 -C 24 alkyl.
9 . The method according to claim 2 , wherein in the compound of formula (II) R 2 -R 3 is C 12 -C 24 alkyl.
10 . The method according to claim 2 , wherein in the compound of formula (II) R 2 -R 3 is C 14 -C 24 alkyl.
11 . The method according to claim 2 , wherein in the compound of formula (II) R 2 -R 3 is C 16 -C 24 alkyl.
12 . The method according to claim 2 , wherein in the compound of formula (II) R 2 -R 3 is C 18 -C 24 alkyl.
13 . The method according to claim 2 , wherein in the compound of formula (II) R 2 -R 3 is C 10 alkyl.
14 . The method according to claim 2 , wherein in the compound of formula (II) R 2 -R 3 is C 12 alkyl
15 . The method according to claim 2 , wherein in the compound of formula (II) R 2 -R 3 is C 14 alkyl.
16 . The method according to claim 2 , wherein in the compound of formula (II) R 2 -R 3 is C 16 alkyl.
17 . The method according to claim 8 , wherein said cancer is in the form of a solid tumor or a liquid tumor.
18 . The method according to claim 17 , wherein said cancer is in the form of a solid tumor.
19 . The method according to claim 18 , wherein said cancer is sarcoma, bladder cancer, cervical cancer, testicular cancer, melanoma, glioblastoma, colon cancer, head and neck cancer, ovarian cancer, prostate cancer, breast cancer, or lung cancer.
20 . The method according to claim 17 , wherein said cancer is in the form of a liquid tumor.
21 . The method according to claim 20 , wherein said cancer is lymphocytic leukemia, Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, or acute lymphocytic leukemia.