IP Library Granted Patent US 11,557,394
Granted Patent B2
US 11,557,394 · App. 15/881,255 · Granted Jan 17, 2023

Systems and methods for optimizing medical care through data monitoring and feedback treatment

Inventors: Dimitar V. Baronov (Boston, MA); Evan J. Butler (New Haven, CT); Jesse M. Lock (Winchester, MA)
Assignee: Etiometry Inc.
G16H40/63A61M5/1723A61M16/0003A61M27/002G16H20/10G16H50/20G16H50/50A61B5/02A61B5/14532A61B5/14542A61B5/14546A61B5/318
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Quick Facts
Patent No.
US 11,557,394
App. No.
15/881,255
Granted
Jan 17, 2023
Kind
B2
Abstract

Systems, methods, and computer-readable media for providing a decision support solution to medical professionals to optimize medical care through data monitoring and feedback treatment are provided herein. In another embodiment, a computer-implemented method for modeling patient outcomes resulting from treatment in a specific medical area includes receiving patient-specific data associated with a patient, determining a plurality of possible patient states under which the patient can be categorized, a current patient state under which the patient can be categorized and determining probabilities of the patient transitioning from any of the possible patient states to every other possible patient state.

Claims (66)

1. A system for event driven patient monitoring and treatment of a patient comprising:

a plurality of physiological sensors configured to be coupled to the patient and configured to produce patient-specific data from the patient, the plurality of physiological sensors including at least a blood oximeter;

a treatment device coupled to the patient and configured to administer a treatment to the patient under control of a computer;

a processor;

a memory coupled to the processor, the memory having computer-executable instructions stored thereon, which when executed by the processor, cause the processor to:

receive patient-specific data associated with the patient, the patient-specific data comprising at least data from the blood oximeter coupled with the patient;

determine a plurality of physiological variables based on the received patient-specific data, the plurality of physiological variables including at least oxygen saturation;

define a state space with DO 2 on a first axis and Q p /Q s on a second axis, the state space partitioned into a plurality of possible clinical patient states defined by a plurality of boundaries, the plurality of possible patient states comprising:

(i) adequate DO 2 along with normal Q p /Q s ;

(ii) inadequate DO 2 along with normal Q p /Q s ;

(iii) adequate DO 2 along with high Q p /Q s ; and

(iv) inadequate DO 2 along with high Q p /Q s ;

wherein a boundary between adequate DO 2 and inadequate DO 2 is 25 ml O 2 /min/kg, and a boundary between normal Q p /Q s and high Q p /Q is a ratio of 1.5,

such that the patient state of adequate DO 2 along with high Q p /Q s is defined by DO 2 greater than 25 ml O 2 /min/kg along with Q p /Q s greater than a ratio of 1.5, and

such that the patient state of inadequate DO 2 along with high Q p /Q s is defined by DO 2 less than 25 ml O 2 /min/kg along with Q p /Q s greater than a ratio of 1.5, and such that

the patient state of inadequate DO 2 along with normal Q p /Q s is defined by DO 2 less than 25 ml O 2 /min/kg along with Q p /Q s less than a ratio of 1.5;

determine from the patient-specific data, a current clinical patient state of the patient within the state space, the current clinical patient state being one of:

(a) inadequate DO 2 along with normal Q p /Q s ;

(b) adequate DO 2 along with high Q p /Q s ; and

(c) inadequate DO 2 along with high Q p /Q s ; and

send a signal to the treatment device coupled to the patient so that the signal causes the treatment device to administer a treatment to the patient, the treatment known to address the current clinical patient state.

2. The system of claim 1 , wherein

(x) the treatment for inadequate DO 2 along with normal Q p /Q s , and the treatment for inadequate DO 2 along with high Q p /Q s , is administration of chronotropic medication; and

(y) the treatment for adequate DO 2 along with high Q p /Q s is administration of vasodilation medication.

3. A method for event driven patient monitoring and treatment of a patient comprising:

coupling a plurality of physiological sensors to the patient, the plurality of physiological sensors configured to produce patient-specific data from the patient, the plurality of physiological sensors including at least a blood oximeter;

coupling a treatment device to the patient, the treatment device configured to administer a treatment to the patient under control of a computer;

receiving at a computer, patient-specific data associated with the patient, the patient-specific data comprising at least data from the blood oximeter coupled with the patient;

determining, by the computer, a plurality of physiological variables based on the received patient-specific data;

defining, by the computer, a state space with DO 2 on a first axis and Q p /Q s on a second axis, the state space partitioned into the plurality of possible clinical patient states defined by a plurality of boundaries, including a boundary between adequate DO 2 and inadequate DO 2 , and a boundary between normal Q p /Q s and high Q p /Q, the plurality of possible patient states comprising:

(i) adequate DO 2 along with normal Q p /Q s ;

(ii) inadequate DO 2 along with normal Q p /Q s ;

(iii) adequate DO 2 along with high Q p /Q s ; and

(iv) inadequate DO 2 along with high Q p /Q s ;

wherein a boundary between adequate DO 2 and inadequate DO 2 is 25 ml O 2 /min/kg, and a boundary between normal Q p /Q s and high Q p /Q is a ratio of 1.5,

such that the patient state of adequate DO 2 along with high Q p /Q s is defined by DO 2 greater than 25 ml O 2 /min/kg along with Q p /Q s greater than a ratio of 1.5, and

such that the patient state of inadequate DO 2 along with high Q p /Q s is defined by DO 2 less than 25 ml O 2 /min/kg along with Q p /Q s greater than a ratio of 1.5, and such that

the patient state of inadequate DO 2 along with normal Q p /Q s is defined by DO 2 less than 25 ml O 2 /min/kg along with Q p /Q s less than a ratio of 1.5;

determining, by the computer, from the physiological variables, a current clinical patient state within the state space, the current clinical patient state being one of:

(a) inadequate DO 2 along with normal Q p /Q s ;

(b) adequate DO 2 along with high Q p /Q s ; and

(c) inadequate DO 2 along with high Q p /Q s ; and

sending a signal from the computer to the treatment device coupled to the patient so that the signal causes the treatment device to administer a treatment to the patient, the treatment known to address the current clinical patient state.

4. The method of claim 3 , wherein

(x) the treatment for inadequate DO 2 along with normal Q p /Q s , and the treatment for inadequate DO 2 along with high Q p /Q s , is administration of chronotropic medication; and

(y) the treatment for adequate DO 2 along with high Q p /Q s is administration of vasodilation medication.

5. A non-transitory computer-readable medium having computer-executable instructions stored thereon, the instructions executable by a computer, the instructions comprising:

instructions to cause the computer to receive patient-specific data associated with the patient, the patient-specific data comprising at least data from one of the plurality of sensors coupled with the patient, the plurality of sensors including at least a blood oximeter;

instructions to cause the computer to determine a plurality of physiological variables based on the received patient-specific data, the plurality of physiological variables including at least oxygen saturation;

instructions to cause the computer to define a state space with DO 2 on a first axis and Q p /Q s on a second axis, the state space partitioned into the plurality of possible clinical patient states defined by a plurality of boundaries, the plurality of possible patient states comprising:

(i) adequate DO 2 along with normal Q p /Q s ;

(ii) inadequate DO 2 along with normal Q p /Q s ;

(iii) adequate DO 2 along with high Q p /Q s ; and

(iv) inadequate DO 2 along with high Q p /Q s ;

wherein a boundary between adequate DO 2 and inadequate DO 2 is 25 ml O 2 /min/kg, and a boundary between normal Q p /Q s and high Q p /Q is a ratio of 1.5,

such that the patient state of adequate DO 2 along with high Q p /Q s is defined by DO 2 greater than 25 ml O 2 /min/kg along with Q p /Q s greater than a ratio of 1.5, and

such that the patient state of inadequate DO 2 along with high Q p /Q s is defined by DO 2 less than 25 ml O 2 /min/kg along with Q p /Q s greater than a ratio of 1.5, and such that

the patient state of inadequate DO 2 along with normal Q p /Q s is defined by DO 2 less than 25 ml O 2 /min/kg along with Q p /Q s less than a ratio of 1.5;

instructions to cause the computer to determine from the physiological variables, a current clinical patient state of the patient within the state space, the current clinical patient state being one of:

(a) inadequate DO 2 along with normal Q p /Q s ;

(b) adequate DO 2 along with high Q p /Q s ; and

(c) inadequate DO 2 along with high Q p /Q s ; and

instructions to cause the computer to control a treatment device by sending a signal to the treatment device coupled to the patient so that the signal causes the treatment device to administer a treatment to the patient, the treatment known to address the current clinical patient state.

6. The non-transitory computer-readable medium of claim 5 , wherein

(x) the treatment for inadequate DO 2 along with normal Q p /Q s , and the treatment for inadequate DO 2 along with high Q p /Q s is administration of chronotropic medication; and

(y) the treatment for adequate DO 2 along with high Q p /Q s is administration of vasodilation medication.

Assignments (3)
SECURITY INTEREST Recorded Aug 8, 2025
From: ETIOMETRY INC.
To: ESCALATE CAPITAL V, LP
Reel/Frame 071974/0584 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 29, 2018
From: BARONOV, DIMITAR V.; BUTLER, EVAN J.; LOCK, JESSE M.
To: ETIOMETRY LLC
Reel/Frame 044750/0799 →
CHANGE OF NAME Recorded Jan 29, 2018
From: ETIOMETRY LLC
To: ETIOMETRY INC.
Reel/Frame 045173/0482 →
Continuity (5)
Continuation 14535149 · Nov 6, 2014
Continuation 13689029 · Nov 29, 2012
Continuation 13698319
Provisional Application 61449176 · Mar 4, 2011
Related Publication 20180169335A1 · Jun 21, 2018