Treatment of
Provided herein are compositions and methods for the treatment or prevention of pathogenic infections.
1. A method of treating Clostridium difficile infection in a subject, the method comprising administering a pharmaceutical composition comprising a purified bacterial mixture consisting of bacterial strains comprising 16S rDNA sequences of at least 97% sequence identity to SEQ ID NO:10, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:19, SEQ ID NO:20, and SEQ ID NO:21, to the subject in an amount sufficient to treat Clostridium difficile infection.
2. The method of claim 1 , wherein the Clostridium difficile infection is a first occurrence of the Clostridium difficile infection.
3. The method of claim 1 , wherein the Clostridium difficile infection is a recurrent Clostridium difficile infection.
4. The method of claim 3 , wherein the subject has been treated with an antibiotic prior to recurrence of the Clostridium difficile infection.
5. The method of claim 1 , further comprising administering an antibiotic.
6. The method of claim 1 , wherein one or more of the bacterial strains are spore-formers.
7. The method of claim 1 , wherein the bacterial strains originate from more than one human donor.
8. The method of claim 1 , wherein the pharmaceutical composition further comprises a pharmaceutically acceptable excipient.
9. The method of claim 1 , wherein the pharmaceutical composition is formulated for oral administration.
10. The method of claim 1 , wherein the pharmaceutical composition wherein the pharmaceutical composition is in the form of a capsule.
11. The method of claim 1 , wherein the pharmaceutical composition is formulated for delivery to the colon.
12. The method of claim 1 , wherein the pharmaceutical composition further comprises one or more enteric polymers.