Granted Patent
B2
US 12,214,003 · App. 18/676,470 · Granted Feb 4, 2025
Composition for inducing proliferation or accumulation of regulatory T cells
Inventors:
Kenya Honda (Tokyo, JP); Koji Atarashi (Tokyo, JP); Kikuji Itoh (Tokyo, JP); Takeshi Tanoue (Tokyo, JP)
Assignee:
The University of Tokyo
A61K35/742A01K67/0275A61K9/0053A61K9/48A61K35/74A61K39/0008A61K39/08A61K39/39A61K45/00A61K45/06C12Q1/689G01N33/505A01K2267/0325A61K35/00A61K2039/52A61K2039/542A61K2039/55594A61K2039/57C12Q2600/158G01N2333/33G01N2500/10
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Abstract
It was found that bacteria belonging to the genus Clostridium induce accumulation of regulatory T cells (Treg cells) in the colon. Moreover, the present inventors found that regulatory T cells (Treg cells) induced by from these bacteria suppressed proliferation of effector T-cells. From these findings, the present inventors found that the use of bacteria belonging to the genus Clostridium or a physiologically active substance derived therefrom made it possible to induce proliferation or accumulation of regulatory T cells (Treg cells), and further to suppress immune functions.
Claims (12)
1. A pharmaceutical composition comprising a spore-forming fraction of human fecal matter;
wherein the pharmaceutical composition is formulated for oral administration;
wherein the spore-forming fraction of human fecal matter in the pharmaceutical composition has been obtained by enriching human fecal matter for a population of spore-forming bacteria therein and comprises two or more bacterial strains; and
wherein the spore-forming fraction of human fecal matter in the pharmaceutical composition induces proliferation and/or accumulation of regulatory T cells and wherein the pharmaceutical composition is in the form of a capsule.
2. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is configured to be administered after antibiotic treatment.
3. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is formulated for delivery to the intestine of a human.
4. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is formulated for delivery to the colon of a human.
5. The pharmaceutical composition of claim 1 , wherein the capsule comprises a hydrogel.
6. The pharmaceutical composition of claim 5 , wherein the hydrogel comprises a cellulose-based polymer.
7. The pharmaceutical composition of claim 1 , wherein the capsule comprises a pH-sensitive composition comprising one or more enteric polymers.
8. The pharmaceutical composition of claim 1 , wherein the regulatory T cells are Foxp3+ regulatory T cells.
9. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition does not include bacteria belonging to the genus Bacteroides.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 19, 2024
From: HONDA, KENYA; ATARASHI, KOJI; TANOUE, TAKESHI; ITOH, KIKUJI
To: THE UNIVERSITY OF TOKYO
Reel/Frame 069749/0435 →
Priority Claims (2)
JP 2010-129134
· Jun 4, 2010
· national
WO PCT/JP2010/071746
· Dec 3, 2010
· international
Continuity (11)
Continuation
13701467
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