IP Library › Granted Patent US 10,294,483
Granted Patent B2
US 10,294,483 · App. 15/887,130 · Granted May 21, 2019

Patent

Inventors: Hyun S. Lillehoj (West Friendship, MD); Sungtaek Oh (Ellicott City, MD); Alfredo Panebra (Chevy Chase, MD)
Assignee: The United States of America, as represented by The Secretary of Agriculture
C12N15/70A61K39/012A61P33/02C07K14/44C07K14/455A61K2039/522A61K2039/552
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Quick Facts
Patent No.
US 10,294,483
App. No.
15/887,130
Granted
May 21, 2019
Kind
B2
Abstract

Provided herein are immunogenic compositions containing recombinant proteins capable of presenting all, or antigenic portions of, the Eimeria tenella Elongation Factor 1 alpha, or EF-1α, protein in the development of active immunity to, and control of, coccidiosis. Also provided are methodologies of using the immunogenic compositions for administration to poultry and other animals in the control of coccidiosis. In some instances, the EF-1α protein utilized in the immunogenic composition presented herein is molecularly manipulated or combined with adjuvants to increase effectiveness.

Claims (14)

1. An immunogenic composition, comprising a pharmaceutically or veterinarily acceptable carrier and a recombinant protein of SEQ ID NO: 2, wherein said immunogenic composition is capable of inducing an immune response to said protein in a recipient.

2. The immunogenic composition of claim 1 , further comprising an adjuvant.

3. The immunogenic composition of claim 1 , wherein the protein is expressed by a recombinant host cell comprising an exogenous nucleic acid encoding the protein.

4. The immunogenic composition of claim 3 , wherein the host cell is an Escherichia coli cell.

5. The immunogenic composition of claim 1 , wherein the carrier is a liquid carrier.

6. The immunogenic composition of claim 1 , wherein the composition is formulated for parenteral delivery.

7. The immunogenic composition of claim 1 , wherein the composition is formulated for oral delivery.

8. The immunogenic composition of any of claims 1 - 7 , wherein the protein is an isolated protein.

9. A method of protecting a recipient against coccidiosis, comprising administering to the recipient an immunogenic composition according to claim 1 or claim 2 in an amount effective to induce a protective immune response to an Eimeria species.

10. The method of claim 9 , wherein the recipient is a chicken or turkey.

11. The method of claim 9 , wherein the immunogenic composition is administered to the recipient at a live whole-cell formulation at a dose of at least 50μg.

12. The method of claim 9 , wherein the composition is administered parenterally.

13. The method of claim 12 , wherein the composition is administered intramuscularly.

14. The method of claim 9 , wherein the composition is administered orally.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 6, 2018
From: LILLEHOJ, HYUN S.; OH, SUNGTAEK; PANEBRA, ALFREDO
To: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE
Reel/Frame 044839/0827 →
Continuity (2)
Provisional Application 62458101 · Feb 13, 2017
Related Publication 20180230475A1 · Aug 16, 2018