IP Library Granted Patent US 11,192,788
Granted Patent B2
US 11,192,788 · App. 15/901,099 · Granted Dec 7, 2021

Two-dimensional amorphous carbon coating and methods of growing and differentiating stem cells

Inventors: Barbaros Ozyilmaz (Singapore, SG); Carlo Mendoza Orofeo (Singapore, SG); Henrik Andersen (Singapore, SG); Hongji Zhang (Singapore, SG); Chee Tat Toh (Singapore, SG); Inigo Martin-Fernandez (Singapore, SG)
Assignee: National University of Singapore
C01B32/05A61L27/08A61L27/303A61L27/50C12N5/0602A61L2420/02C01P2002/02C01P2002/04C01P2002/20C01P2006/40C12N2501/10C12N2533/00
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Quick Facts
Patent No.
US 11,192,788
App. No.
15/901,099
Granted
Dec 7, 2021
Kind
B2
Abstract

Described is a composite material composed of an atomically thin (single layer) amorphous carbon disposed on top of a substrate (metal, glass, oxides) and methods of growing and differentiating stem cells.

Claims (11)

1. A two-dimensional amorphous carbon (2DAC) coating having an atomic structure consisting of non-hexagonal carbon rings and hexagonal carbon rings,

wherein the 2D amorphous carbon coating has a crystallinity (C)<1 and a sp 3 /sp 2 bond ratio is 0.2 or less,

wherein C (crystallinity)=number of hexagons:(number of hexagons+number of non-hexagons), and

wherein the coating is an implant coating.

2. The coating of claim 1 , wherein the 2D amorphous carbon coating has a crystallinity (C)≤0.8.

3. The coating of claim 1 , wherein the 2D amorphous carbon coating has a resistivity of 0.01 to 1000 Ω-cm, inclusive.

4. The coating of claim 1 , wherein the implant coating forms a contact angle of about 60° with a surface of an implant.

5. The coating of claim 1 , wherein the implant coating adheres to an implant with an adhesion energy of about 200 J/m 2 or greater.

6. The coating of claim 1 , wherein the non-hexagonal carbon rings are in the form of one selected from the group consisting of: 4-membered carbon rings, 5-membered carbon rings, 7-membered carbon rings, 8-membered carbon rings and 9-membered carbon rings.

7. The coating of claim 1 , comprising:

an optical transparency equal to or greater than 98% at a wavelength of 550 nm or higher.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 29, 2018
From: OZYILMAZ, BARBAROS; OROFEO, CARLO MENDOZA; ANDERSEN, HENRIK; ZHANG, HONGJI; TOH, CHEE TAT; MARTIN FERNANDEZ, INIGO
To: NATIONAL UNIVERSITY OF SINGAPORE
Reel/Frame 046743/0841 →
Continuity (3)
Provisional Application 62546680 · Aug 17, 2017
Provisional Application 62463112 · Feb 24, 2017
Related Publication 20180244524A1 · Aug 30, 2018
Cited By (3)
US 12,264,070 US 12,365,590 US 12,431,350