IP Library Granted Patent US 10,532,228
Granted Patent B2
US 10,532,228 · App. 15/901,770 · Granted Jan 14, 2020

Multi-color charged particle detector apparatus and method of use thereof

Inventors: Maureen Petterson (Somerville, MA); W. Davis Lee (Newburyport, MA)
A61N5/1077A61B6/03A61N5/1067A61N5/1082G21K1/087G21K1/093G21K5/04A61N5/107A61N5/1044A61N2005/1074A61N2005/1087A61N2005/1097H01J35/14
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Quick Facts
Patent No.
US 10,532,228
App. No.
15/901,770
Granted
Jan 14, 2020
Kind
B2
Abstract

The invention comprises a method and apparatus for using a multi-layer multi-color scintillation based detector element to image a tumor of a patient using a process of determining residual energies of positively charged particles after passing through the patient, the process comprising the steps of: (1) transmitting the positively charged particles at known energies through the patient and into a multi-layer detector element; (2) detecting first and second secondary photons, resultant from passage of the positively charged particles, respectively from a first layer of a first scintillation material and a second layer of a second scintillation material at two respective layer depths, where the first wavelength range differs from the second wavelength range; (4) determining residual energies of the positively charged particles, using output from the step of detecting; and (5) relating the residual energies to body densities to generate an image.

Claims (33)

1. An apparatus for determining residual energy of positively charged particles after passing through a patient, comprising:

a multi-layer detector, comprising;

a first layer comprising a first scintillation material, said first scintillation material, responsive to passage of the positively charged particles, emitting first secondary photons over a first wavelength range;

a second layer comprising a second scintillation material, said second scintillation material, responsive to passage of the positively charged particles, emitting second secondary photons over a second wavelength range, the first scintillation material differing from the second scintillation material;

a third layer comprising a third scintillation material, said third scintillation material, responsive to passage of the positively charged particles, emitting third secondary photons over a third wavelength range, said third scintillation material differing from both said first scintillation material and said second scintillation material; and

orientation of said first layer, said second layer, and said third layer within thirty degrees of orthogonal to a path of the positively charge particles, said second layer positioned between said first layer and said third layer, a front surface of said second layer within ten centimeters of said first layer, a back surface of said second layer within ten centimeters of said third layer.

2. The apparatus of claim 1 , said multi-layer detector further comprising:

a first sub-stack of scintillation materials comprising said first layer, said second layer, and said third layer; and

a second sub-stack comprising a manufactured copy of said first sub-stack.

3. The apparatus of claim 2 , said multi-layer detector further comprising:

at least ten layers of scintillation materials, said at least ten layers of scintillation materials comprising:

said first sub-stack; and

said second sub-stack.

4. The apparatus of claim 1 , further comprising:

an imaging system configured to use output from said multi-layer detector to generate an image of a tumor of the patient.

5. A multi-layer detector, comprising:

a first layer comprising a first scintillation material, said first scintillation material, responsive to passage of the positively charged particles, emitting first secondary photons over a first wavelength range; and

a second layer comprising a second scintillation material, said second scintillation material, responsive to passage of the positively charged particles, emitting second secondary photons over a second wavelength range, the first scintillation material differing from the second scintillation material,

wherein said first scintillation material further comprises a first responsivity to the positively charged particles at least twice as responsive, in terms of number of emitted photons per unit energy released from the positively charged particles, as said second scintillation material.

6. The apparatus of claim 5 , further comprising:

an accelerator configured to generated the positively charged particles;

a beam transport system configured to transport the positively charged particles from said accelerator, over a patient positioning system, and into said multi-layer detector.

7. The apparatus of claim 5 , further comprising:

an imaging system configured to use output from said multi-layer detector to generate an image of the patient.

8. A method for determining residual energy of positively charged particles after passing through a patient, comprising the steps of:

passing the positively charged particles into a multi-layer detector element;

detecting first secondary photons, resultant from passage of the positively charged particles, over a first wavelength range from a first layer of said multi-layer detector, said first layer comprising a first scintillation material; and

detecting second secondary photons, resultant from passage of the positively charged particles, over a second wavelength range from a second layer of said multi-layer detector element, the first wavelength range differing from the second wavelength range; and

generating a set of response signals, each of at least six individual members of said set of response signals relating to a corresponding layer of a set of at least six layers of said multi-layer detection element.

9. The method of claim 8 , further comprising the step of:

detecting third secondary photons, resultant from passage of the positively charged particles, over a third wavelength range from a third layer of said multi-layer detector element, a third mean wavelength of the third wavelength range differing from both a first mean wavelength of the first wavelength range and a second mean wavelength of the second wavelength range by at least ten nanometers.

10. The method of claim 8 , further comprising the step of:

generating said set of response signals using two or three distinct scintillation material types.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 29, 2019
From: PETTERSON, MAUREEN; LEE, W. DAVIS
To: PROTOM INTERNATIONAL HOLDING CORPORATION D/B/A PROTOM INTERNATIONAL
Reel/Frame 051144/0874 →
Continuity (13)
Continuation In Part 15892240 · Feb 8, 2018
Continuation In Part 15868897 · Jan 11, 2018
Continuation In Part 15838072 · Dec 11, 2017
Continuation In Part 15823148 · Nov 27, 2017
Continuation In Part 15467840 · Mar 23, 2017
Continuation In Part 15402739 · Jan 10, 2017
Continuation In Part 15348625 · Nov 10, 2016
Continuation In Part 15167617 · May 27, 2016
Continuation 15152479 · May 11, 2016
Continuation In Part 14216788 · Mar 17, 2014
Continuation In Part 13087096 · Apr 14, 2011
Provisional Application 61324776 · Apr 16, 2010
Related Publication 20180178039A1 · Jun 28, 2018
Cited By (1)
US 12,245,355