Phenothiazine diaminium salts and their use
Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.
1. A method of treating a disease selected from the group consisting of: skin cancer or melanoma; a viral disease; a bacterial disease; and a protozoal disease, the method comprising administering to a subject in need thereof the compound of the following formula:
or a pharmaceutically acceptable salt, solvate, or hydrate thereof.
2. The method of claim 1 , wherein the administering is oral.
3. The method of claim 2 , wherein the administering is selected from:
(a) about 100 mg of compound, 3 times daily;
(b) about 150 mg of compound, 2 times daily; and
(c) about 200 mg of compound, 2 times daily.
4. The method of claim 1 , wherein the disease is skin cancer or melanoma.
5. The method of claim 1 , wherein the disease is a viral disease.
6. The method of claim 5 , wherein the viral disease is selected from the list consisting of: Hepatitis C; HIV; and West Nile Virus.
7. The method of claim 1 , wherein the disease is a bacterial disease.
8. The method of claim 1 , wherein the disease is a protozoal disease.
9. The method of claim 7 , wherein the protozoal disease is malaria.