System and method for multi-axis imaging of specimens
A specimen holding and positioning apparatus operable to substantially non-movably maintain a specimen (e.g., an excised tissue specimen) in a fixed or stable orientation with respect to the apparatus during imaging operations (e.g., x-ray imaging), transport (e.g., from a surgery room to a pathologist's laboratory), and the like for use in facilitating accurate detection and diagnosis of cancers and/or other abnormalities of the specimen.
1. A method of imaging a specimen, comprising:
elastically deforming first and second retention members of a positioning apparatus to surround opposing portions of a specimen;
securing the first and second retention members against movement relative to each other to retain the specimen therebetween within a specimen support volume of the apparatus, wherein a reference plane extends between the first and second retention members when the specimen is retained therebetween;
first imaging the specimen along a first axis that is one of substantially parallel or perpendicular to the reference plane to obtain a first image;
reorienting the apparatus; and
second imaging the specimen along a second axis that is the other of substantially parallel or perpendicular to the reference plane to obtain a second image.
2. The method of claim 1 , further including before the elastically deforming:
disposing the specimen within an opening of the first retention member.
3. The method of claim 2 , wherein the elastically deforming includes:
inserting the second retention member into the opening of the first retention member.
4. The method of claim 1 , wherein the apparatus includes:
a first volume extending about and along the first axis from a first external side of the apparatus to a second external side of the apparatus and encompassing the specimen support volume; and
a second volume extending about and along the second axis from a third external side of the apparatus to a fourth external side of the apparatus and encompassing the specimen support volume, wherein the first and second volumes are free of any portion having a density greater than either a density of the portion of the first retention member or a density of the portion of the second retention member.
5. The method of claim 1 , wherein the reorienting includes rotating the positioning apparatus about a rotation axis.
6. The method of claim 5 , wherein the imaging includes sending a beam of electromagnetic radiation along an imaging axis, and wherein the rotation axis is substantially perpendicular to the imaging axis.
7. The method of claim 5 , wherein the rotating including rotating the positioning apparatus about the rotation axis by 90 degrees.
8. The method of claim 1 , further comprising:
using the first and second images to verify tissue margins of the specimen.
9. The method of claim 1 , further comprising:
separating the first and second retention members from each other;
lifting the specimen away from the first retention member;
locating a location identification member on the first retention member;
placing the specimen over the location identification member;
advancing at least one of the first and second retention members towards the other of the first and second retention members;
elastically deforming, during the advancing, the first and second retention members about the location identification member and the specimen;
securing, after the elastically deforming, the first and second retention members against movement relative to each other to retain the specimen and location identification member between the first and second retention members;
third imaging the specimen along the one of the first and second axes that is substantially perpendicular to the reference plane to obtain a third image, wherein the third imaging includes generating a bean of electromagnetic radiation that is free of contact with any structures other than the specimen, the first and second retention members, and the location identification member along the one of the first and second axes between a source and an imaging detector.
10. The method of claim 9 , wherein the location identification member comprises radiopaque indicia across at least a surface thereof, wherein the third image includes the indicia, and wherein the method further includes:
using the indicia of the third image to identify one or more areas of interest in the specimen.
11. The method of claim 1 , wherein each of the first and second retention members comprises a polymeric material.
12. The method of claim 11 , wherein the polymeric material is a foam.