IP Library › Patent Application 15915967
Patent Application
App. No. 15/915,967

Solid Phase Assay for Detecting Biomarkers for Cardiodiabetes

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Quick Facts
Patent No.
US None
App. No.
15/915,967
Abstract

The invention provides compositions and methods for determining cardiodiabetes status in a subject. The invention also provides compositions and methods for treating a subject experiencing cardiodiabetes.

Claims (15)

1 . A composition comprising a solid support comprising:

(a) a capture binding ligand selective for adiponectin,

(b) a capture binding ligand selective for high sensitivity C-reactive protein (hsCRP) wherein the capture binding ligand can detect a hsCRP concentration of less than 10 mg/L, and

(c) a capture binding ligand selective for intact proinsulin.

2 . The composition of claim 1 wherein one of the capture binding ligands comprises an antibody.

3 . The composition of claim 1 wherein the composition further comprises:

(a) a soluble capture ligand selective for adiponectin,

(b) a soluble capture ligand selective for hsCRP, and

(c) a soluble capture ligand selective for intact proinsulin.

4 . The composition of claim 3 wherein each of the soluble capture ligands comprises a detectable marker.

5 . The composition of claim 4 wherein a detectable marker is a fluorophore.

6 . The composition of claim 4 wherein a detectable marker is a conjugated enzyme.

7 . The composition of claim 6 wherein the conjugated enzyme is horseradish peroxidase.

8 . The composition of claim 1 further comprising a detector.

9 .- 22 . (canceled)