Methods of treating feline coronavirus infections
View Patent ↗Provided are methods of treating feline Coronavirus infections using carbanucleoside compounds having a 1′-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl) substituent, or a pharmaceutically acceptable salt thereof. An exemplary compound is (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile.
1. A method of treating a feline Coronavirus infection in a cat in need thereof comprising administering to the cat a therapeutically effective amount of a compound of formula:
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the feline Coronavirus infection is feline enteric coronavirus (FECV) or feline infectious peritonitis virus (FIPV).
3. The method of claim 1 , wherein the compound is a compound of formula:
or a pharmaceutically acceptable salt thereof.
4. A method of treating a feline Coronavirus infection in a cat in need thereof comprising administering to the cat a therapeutically effective amount of a compound of formula
or a pharmaceutically acceptable salt thereof.
5. The method of claim 4 , wherein the feline Coronavirus infection is feline enteric coronavirus (FECV) or feline infectious peritonitis virus (FIPV).
6. The method of claim 4 , wherein the compound is a compound of formula:
7. A method of treating a feline enteric coronavirus (FECV) infection in a cat in need thereof comprising administering to the cat a therapeutically effective amount of a compound of formula:
or a pharmaceutically acceptable salt thereof.
8. The method of claim 7 , wherein the compound is a compound of formula:
or a pharmaceutically acceptable salt thereof.
9. A method of treating a feline enteric coronavirus (FECV) infection in a cat in need thereof comprising administering to the cat a therapeutically effective amount of a compound of formula
or a pharmaceutically acceptable salt thereof.
10. The method of claim 9 , wherein the compound is a compound of formula:
11. A method of treating a feline infectious peritonitis virus (FIPV) infection in a cat in need thereof comprising administering to the cat a therapeutically effective amount of a compound of formula:
or a pharmaceutically acceptable salt thereof.
12. The method of claim 11 , wherein the compound is a compound of formula:
or a pharmaceutically acceptable salt thereof.
13. A method of treating feline infectious peritonitis virus (FIPV) infection in a cat in need thereof comprising administering to the cat a therapeutically effective amount of a compound of formula
or a pharmaceutically acceptable salt thereof.
14. The method of claim 13 , wherein the compound is a compound of formula:
15. A method of treating feline infectious peritonitis (FIP) in a cat in need thereof comprising administering to the cat a therapeutically effective amount of a compound of formula:
or a pharmaceutically acceptable salt thereof.
16. The method of claim 15 , wherein the compound is a compound of formula:
or a pharmaceutically acceptable salt thereof.
17. A method of treating feline infectious peritonitis (FIP) in a cat in need thereof comprising administering to the cat a therapeutically effective amount of a compound of formula
or a pharmaceutically acceptable salt thereof.
18. The method of claim 17 , wherein the compound is a compound of formula: