Granted Patent
B2
US 10,307,422 · App. 15/924,831 · Granted Jun 4, 2019
Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome
Inventors:
Roland Werner Bürli (Bishop's Stortford, GB); William Rameshchandra Krishna Esmieu (Cambridge, GB); Christopher James Lock (Burwell, GB); Karine Fabienne Malagu (Saffron Walden, GB); Andrew Pate Owens (Huntingdon, GB); William E. Harte (Moorpark, CA)
Assignee:
USHER III INITIATIVE, INC.
A61K31/5025A61K31/165A61K31/167A61K31/40C07C251/86C07D487/04C07D519/00G01N33/502G01N33/6848G01N33/6893C07C2602/08G01N2333/4703G01N2400/40G01N2500/04G01N2500/10
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Abstract
Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
Claims (4)
1. A composition comprising an effective amount of
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or vehicle.
2. A composition comprising an effective amount of
and a pharmaceutically acceptable carrier or vehicle.
Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 29, 2018
From: BÜRLI, ROLAND WERNER; ESMIEU, WILLIAM RAMESHCHANDRA KRISHNA; LOCK, CHRISTOPHER JAMES; MALAGU, KARINE FABIENNE; OWENS, ANDREW PATE
To: BIOFOCUS DPI LTD.
Reel/Frame 045383/0784 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 29, 2018
From: BIOFOCUS DPI LTD.
To: USHER III INITIATIVE, INC.
Reel/Frame 045383/0846 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 29, 2018
From: HARTE, WILLIAM E.
To: USHER III INITIATIVE, INC.
Reel/Frame 045383/0866 →
Continuity (9)
Continuation
PCTUS2012034959
· Apr 25, 2012
Provisional Application
61576471
· Dec 16, 2011
Provisional Application
61537908
· Sep 22, 2011
Provisional Application
61478642
· Apr 25, 2011
Cited By (1)