Combined Sensor Apparatus for Breath Gas Analysis
A monitoring system is disclosed that includes features for detecting the presence of biomarkers from a gas sample, such as exhaled breath. An assembly may also includes a plurality of sensors to detect biomarkers present in exhaled breath that are associated with respiratory illness. The biomarkers include carbon dioxide, carbon monoxide, and nitric oxide.
1 . An apparatus for detecting respiratory disease comprising:
(a) a housing comprising a breath flow pathway disposed within the housing;
(b) a breath gas inlet positioned at an entrance of the breath flow pathway;
(c) a carbon monoxide (CO) sensor detection element positioned in the breath flow pathway, downstream from the breath gas inlet;
(d) a carbon dioxide (CO 2 ) sensor detection element positioned in the breath flow pathway, downstream from the CO sensor detection element; and
(e) a breath outlet positioned at an exit of the breath flow pathway, downstream from the sensor detection elements.
2 . The apparatus of claim 1 , further comprising a heating element disposed on an upstream side of the CO sensor detection element.
3 . The apparatus of claim 1 , wherein the CO sensor detection element comprises a metal oxide semiconductor type sensor.
4 . The apparatus of claim 3 , wherein the CO 2 sensor detection element comprises a spectroscopic nondispersive infrared (NDIR) CO 2 sensor.
5 . An apparatus for detecting respiratory disease comprising:
(a) a housing comprising a breath flow pathway disposed within the housing;
(b) a breath gas inlet positioned at an entrance of the breath flow pathway;
(c) a carbon dioxide (CO 2 ) sensor element positioned in the breath flow pathway, downstream from the breath gas inlet;
(d) a carbon monoxide (CO) sensor element positioned in the breath flow pathway, downstream from the CO 2 sensor element;
(e) a nitric oxide (NO) sensor element positioned in the breath flow pathway, downstream from the CO sensor element; and
(f) a breath outlet positioned at an exit of the breath flow pathway, downstream from the sensor elements.
6 . The apparatus of claim 5 , wherein the NO sensor element comprises a micro-channel reactor filter comprising platinum and zeolite, and a potentiometric sensor.
7 . The apparatus of claim 6 , wherein the NO sensor element further comprises a micro-channel reactor filter heater relay.
8 . The apparatus of claim 5 , further comprising a humidity controller configured to regulate the humidity of a breath sample in at least a portion of the breath flow pathway.
9 . The apparatus of claim 5 , further comprising an excess exhaust portal adapted to release from the housing a portion of a breath gas sample entering the breath gas inlet while another portion of the breath gas sample proceeds to the CO 2 sensor element.
10 . A multi-sensor apparatus for monitoring respiratory disease comprising:
(a) a housing comprising a breath flow pathway disposed within the housing;
(b) a breath inlet positioned at an entrance of the breath flow pathway;
(c) a plurality of sensors positioned in the breath flow pathway, downstream from the breath inlet, wherein each sensor is configured to detect the presence of a biomarker indicative of respiratory disease; and
(d) a breath outlet positioned at an exit of the breath flow pathway, downstream from the sensors.
11 . The apparatus of claim 10 , further comprising an exhaust portal adapted to release a portion of a breath gas sample entering the breath inlet without contacting the sensors.
12 . The apparatus of claim 10 , wherein the plurality of sensors comprises a carbon monoxide (CO) selective sensor and a carbon dioxide (CO 2 ) selective sensor.
13 . The apparatus of claim 12 , further comprising a heating element disposed on an upstream side of the CO selective sensor.
14 . The apparatus of claim 12 , wherein the CO selective sensor comprises a metal oxide semiconductor type sensor.
15 . The apparatus of claim 12 , wherein the CO 2 selective sensor comprises a spectroscopic nondispersive infrared (NDIR) CO 2 sensor.
16 . The apparatus of claim 10 , wherein the plurality of sensors comprises a carbon dioxide (CO 2 ) selective sensor, a carbon monoxide (CO) selective sensor, and a nitric oxide (NO) selective sensor.
17 . The apparatus of claim 10 , wherein the biomarker is selected from the group consisting of carbon dioxide (CO 2 ), carbon monoxide (CO), and nitric oxide (NO).
18 . The apparatus of claim 10 , wherein the plurality of sensors is selected from the group consisting of a carbon dioxide (CO 2 ) selective sensor, a carbon monoxide (CO) selective sensor, and a nitric oxide (NO) selective sensor.
19 . A method for detecting respiratory disease comprising:
(a) flowing a breath gas sample through a breath inlet positioned at an entrance of a housing, wherein the housing comprises a breath flow pathway disposed within the housing;
(b) exposing the breath gas sample to a carbon dioxide (CO 2 ) sensor detection element positioned in the breath flow pathway, downstream from the breath inlet;
(c) exposing the breath gas sample to a carbon monoxide (CO) sensor detection element positioned in the breath flow pathway, downstream from the CO 2 sensor detection element; and
(d) releasing the breath gas sample through a breath outlet positioned at an exit of the breath flow pathway.
20 . The method of claim 19 , further comprising the step of heating the breath gas sample using a heating element disposed on an upstream side of the CO sensor detection element.
21 . The method of claim 19 , wherein the CO sensor detection element comprises a metal oxide semiconductor type sensor.
22 . The method of claim 21 , wherein the CO 2 sensor detection element comprises a spectroscopic nondispersive infrared (NDIR) CO 2 sensor.