Topical compositions for pain relief, manufacture and use
The present invention relates to TRPV1 selective agonist compositions including a capsaicinoid, a surfactant and an extended release agent, and to methods of manufacture and methods of providing pain relief as well as treating a variety of disorders with such compositions.
1. A method of treating pain in a mammal suffering from pain comprising topically administering a composition to said mammal, the composition comprising
i) 0.075-20% by weight of a capsaicinoid,
ii) an extended release agent to slow the release of said capsaicinoid from said composition upon administration of said composition to a mammal, and
iii) a surfactant.
2. A method as in claim 1 wherein said mammal is a human.
3. A method as in claim 1 further comprising administering an NSAID.
4. A method as in claim 1 wherein said pain is arthritis pain.
5. A method as in claim 4 wherein said arthritis pain is osteoarthritis or rheumatoid arthritis pain.
6. A method of treating a capsaicin responsive condition in a mammal suffering from said condition comprising topically administering a composition to said mammal, the composition comprising
i) 0.075-20% by weight of a capsaicinoid,
ii) an extended release agent to slow the release of said capsaicinoid from said composition upon administration of said composition to a mammal, and
iii) a surfactant.
7. A method as in claim 6 wherein the capsaicin responsive condition is pain including neuropathic pain, inflammatory hyperalgia, vulvodynia, interstitial cystitis, rhinitis, burning mouth syndrome, oral mucositis, herpes, dermatitis, pruritus, tinnitus, psoriasis, or headaches.
8. A method of treating itching in a mammal comprising topically administering a composition, the composition comprising
i) 0.075-20% by weight of a capsaicinoid,
ii) an extended release agent to slow the release of said capsaicinoid from said composition upon administration of said composition to a mammal, and
iii) a surfactant.
9. A method of formulating an aqueous capsaicinoid formulation comprising:
i) dissolving a capsaicinoid in a surfactant to form a solution, and
ii) adding hyaluronic acid to the solution.
10. A method of producing an aqueous topical formulation of capsaicin comprising:
i) mixing a capsaicinoid and a surfactant and ethanol, and
ii) adding hyaluronic acid.