Granted Patent
B2
US 10,322,094 · App. 15/941,484 · Granted Jun 18, 2019
Eutectic formulations of cyclobenzaprine hydrochloride and amitriptyline hydrochloride
Assignee:
Tonix Pharma Holdings Limited
A61K31/135A61K9/145A61K9/1623A61K9/1688A61K9/1694A61K31/047A61K31/137A61K47/02A61K47/10A61K47/12A61K47/26A61K31/55
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Abstract
The present invention relates to pharmaceutical compositions and methods of manufacturing the same, comprising a eutectic of Cyclobenzaprine HCl and mannitol or Amitriptyline HCl and mannitol.
Claims (4)
1. A pharmaceutical composition comprising a eutectic of mannitol and Amitriptyline HCl, wherein the eutectic comprises 75%±2% by weight Amitriptyline HCl and 25%±2% by weight mannitol.
2. The pharmaceutical composition of claim 1 , wherein the Amitriptyline HCl is micronized Amitriptyline HCl.
3. The pharmaceutical composition of claim 1 , or 2 , further comprising a basifying agent.
4. The pharmaceutical composition of claim 3 , wherein the basifying agent is K 2 HPO 4 , Na 2 HPO 4 or anhydrous trisodium citrate.
Assignments (5)
NOVATION AGREEMENT
Recorded Jul 8, 2024
From: TONIX PHARMA HOLDINGS LIMITED
To: TONIX PHARMA LIMITED
Reel/Frame 068217/0592 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Feb 25, 2020
From: TONIX PHARMACEUTICALS, INC.
To: TONIX PHARMA HOLDINGS LIMITED
Reel/Frame 052010/0959 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 30, 2018
From: NEBULONI, MARINO; COLOMBO, PATRIZIA
To: REDOX SRL
Reel/Frame 045397/0164 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 30, 2018
From: REDOX SRL
To: TONIX PHARMACEUTICALS, INC.
Reel/Frame 045397/0178 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 30, 2018
From: TONIX PHARMACEUTICALS, INC.
To: TONIX PHARMA HOLDINGS LIMITED
Reel/Frame 045397/0207 →
Continuity (4)
Provisional Application
61792757
· Mar 15, 2013